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Category: genetics – Page 306

E5 On Dogs Project: Validating The 54% Reduction In Epigenetic Age | Dr Greg Fahy Episode 8

The Conboys are looking at human trials soon but not with E5. it will be interesting to see how their trial compares to this E5 dog trial.

In this video Dr. Fahy shares his opinion on some of the up and coming anti-aging therapies, including NAD boosters, Hyperbaric Oxygen Chambers and senolytics.

Intervene Immune website:

Intro page


Contact to join the trial or invest.

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Dr. Greg Fahy is a world renowned cryobiologist and is also the chief science officer, and co-founder, of Intervene Immune, a company which pioneers treatments for thymus regeneration and age-related immune system decline. Dr. Fahy Designed and led the pilot TRIIM trial which first time showing both thymus rejuvenation and reversal of human epigenetic age. He is now running the follow up phase II trial TRIIM-X with the aim of confirming and extending the results.

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What AI researchers can learn from the self-assembling brain

But one idea that hasn’t gotten enough attention from the AI community is how the brain creates itself, argues Peter Robin Hiesinger, Professor of Neurobiology at the Free University of Berlin (Freie Universität Berlin).

In his book The Self-Assembling Brain, Hiesinger suggests that instead of looking at the brain from an endpoint perspective, we should study how information encoded in the genome is transformed to become the brain as we grow. This line of study might help discover new ideas and directions of research for the AI community.

The Self-Assembling Brain is organized as a series of seminar presentations interspersed with discussions between a robotics engineer, a neuroscientist, a geneticist, and an AI researcher. The thought-provoking conversations help to understand the views and the holes of each field on topics related to the mind, the brain, intelligence, and AI.

CRISPR gene editing: The key benefits (and risks) of modifying our natural world

What’s confusing is that some of the modifications we’re now considering could have been achieved years ago through traditional methods, so our views depend on what we think about the safety of new editing technologies, but also how desperate we are to address environmental degradation.

A process that began centuries ago with selective breeding has developed into genetic modification. We explore the consequences of these controversial tools.

Hershey And Chase Experiment | Discovery Of DNA As Genetic Material

This video explains hershey and chase experiment | discovery of DNA as genetic material.

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UAT Virtual Let’s Talk Tech Open House

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University of Advancing Technology’s Artificial Intelligence (AI) degree explores the theory and practice of engineering tools that simulate thinking, patterning, and advanced decision behaviors by software systems. With inspiration derived from biology to design, UAT’s Artificial Intelligence program teaches students to build software systems that solve complex problems. Students will work with technologies including voice recognition, simulation agents, machine learning (ML), and the internet of things (IoT).

Students pursuing this specialized computer programming degree develop applications using evolutionary and genetic algorithms, cellular automata, artificial neural networks, agent-based models, and other artificial intelligence methodologies. UAT’s degree in AI covers the fundamentals of general and applied artificial intelligence including core programming languages and platforms used in computer science.

How a Specific Synapse Type Regulates Anxiety-Like Behavior

“Our research may help us understand how abnormalities in anxiety-like behavior occur and design circuit-based therapeutic approaches for correcting them,” remarks Professor Ji Won Um from the Department of Brain and Cognitive Sciences at DGIST, who led the study.

Summary: Study identifies the role a specific protein plays in regulating the development of inhibitory synapses in the hippocampus in the context of anxiety-related behaviors.

Source: DGIST

The mechanisms behind the organization of neuronal synapses remain unclear owing to the sheer number of genes, proteins, and neuron types involved. In a recent study, Daegu Gyeongbuk Institute of Science and Technology scientists conducted a series of experiments in genetically modified mice to clarify the role of two proteins in regulating the development of inhibitory synapses in the hippocampus, in the context of anxiety-related behaviors, paving the way to better understand the brain.

The correct functioning of our brain, as well as that of other animals, depends on a very intricate interplay between multiple types of neurons. These interactions are orchestrated by multitudes of synaptic proteins; thus, pinpointing their specific functions is extremely challenging. In particular, the molecular mechanisms that regulate the plasticity of synapses are not completely understood.

Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial

Yes this says a 3 year epigenetic clock reversal in just 8 weeks thanks to diet and lifestyle changes. There is a list of supplements too:

Alpha ketoglutarate, vitamin C and vitamin A curcumin, epigallocatechin gallate (EGCG), rosmarinic acid, quercetin, luteolin.

Manipulations to slow biological aging and extend healthspan are of interest given the societal and healthcare costs of our aging population. Herein we report on a randomized controlled clinical trial conducted among 43 healthy adult males between the ages of 50–72. The 8-week treatment program included diet, sleep, exercise and relaxation guidance, and supplemental probiotics and phytonutrients. The control group received no intervention. Genome-wide DNA methylation analysis was conducted on saliva samples using the Illumina Methylation Epic Array and DNAmAge was calculated using the online Horvath DNAmAge clock (2013). The diet and lifestyle treatment was associated with a 3.23 years decrease in DNAmAge compared with controls (p=0.018). DNAmAge of those in the treatment group decreased by an average 1.96 years by the end of the program compared to the same individuals at the beginning with a strong trend towards significance (p=0.066). Changes in blood biomarkers were significant for mean serum 5-methyltetrahydrofolate (+15%, p=0.004) and mean triglycerides (−25%, p=0.009). To our knowledge, this is the first randomized controlled study to suggest that specific diet and lifestyle interventions may reverse Horvath DNAmAge (2013) epigenetic aging in healthy adult males. Larger-scale and longer duration clinical trials are needed to confirm these findings, as well as investigation in other human populations.

Keywords: DNA methylation, epigenetic, aging, lifestyle, biological clock.

Advanced age is the largest risk factor for impaired mental and physical function and many non-communicable diseases including cancer, neurodegeneration, type 2 diabetes, and cardiovascular disease [1, 2]. The growing health-related economic and social challenges of our rapidly aging population are well recognized and affect individuals, their families, health systems and economies. Considering economics alone, delaying aging by 2.2 years (with associated extension of healthspan) could save $7 trillion over fifty years [3]. This broad approach was identified to be a much better investment than disease-specific spending. Thus, if interventions can be identified that extend healthspan even modestly, benefits for public health and healthcare economics will be substantial.

This new discovery could allow dentists to regenerate the roots of teeth

Circa 2019

To figure out how the body changes over time, researchers are increasingly looking to understand epigenetics, the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself. This scientific endeavor extends to teeth as well.

Yang Chai, associate dean of research at the Herman Ostrow School of Dentistry of USC, reported in a recent article how he and colleagues discovered that epigenetic regulation can control tooth root patterning and development.

“This is an aspect that doesn’t involve change in the DNA sequence, but it’s basically through the control where you make the genes available or unavailable for transcription, which can determine the pattern,” he explained.