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Flu virus shells could improve delivery of mRNA into cells

Nanoengineers at the University of California San Diego have developed a new and potentially more effective way to deliver messenger RNA (mRNA) into cells. Their approach involves packing mRNA inside nanoparticles that mimic the flu virus—a naturally efficient vehicle for delivering genetic material such as RNA inside cells.

The new mRNA nanoparticles are described in a paper published recently in the journal Angewandte Chemie International Edition.

The work addresses a major challenge in the field of drug delivery: Getting large biological drug molecules safely into and protecting them from organelles called endosomes. These tiny acid-filled bubbles inside the cell serve as barriers that trap and digest large molecules that try to enter. In order for biological therapeutics to do their job once they are inside the cell, they need a way to escape the endosomes.

HUMAN AUGMENTATION EXAMPLES — Webinar at Brave New World | Peter Joosten MSc

Human Augmentation Examples. What are examples of augmentations to the human body? Should we allow such augmentation methods and technologies? What are dangers, and risks involved? How can society benefit from these developments?

On Brave New World conference 2020 I gave this webinar with the title: ‘The Human Body. The Next Frontier’.

Please leave a comment if you like the video or when you have a question!

Content:
0:00 Start.
0:29 Introduction by moderator Jim Stolze.
1:05 My story.
2:54 Jetson Fallacy (by professor Michael Bess)
3:43 Examples: data, genetic modification, and neuroscience.
6:09 Benefits.
7:09 Risks and dangers.
8:28 Stakeholders: companies, countries, and military organizations.
11:54 Solutions: regulation, debate, and stories.
14:42 My conclusion.
15:03 End.

🙌 Hire me:
Keynote or webinar: https://peterjoosten.org.

🚀 Want to know more:

MIT researchers discover bacteria’s new antiviral defense system

Specific proteins in prokaryotes detect viruses in unexpectedly direct ways.

Bacteria use a variety of defense strategies to fight off viral infection. STAND ATPases in humans are known to respond to bacterial infections by inducing programmed cell death in infected cells. Scientists predict that many more antiviral weapons will be discovered in the microbial world in the future. Scientists have discovered a new unexplored microbial defense system in bacteria.

Researchers uncovered specific proteins in prokaryotes (bacteria and archaea) that detect viruses in unexpectedly direct ways, recognizing critical parts of the viruses and causing the single-celled organisms to commit suicide to stop the infection within a microbial community, according to a press release published in the official website of the Massachusetts Institute of Technology (MIT) on Thursday.

The discovery was made by a team of scientists led by researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT.

“This work demonstrates a remarkable unity in how pattern recognition occurs across very different organisms,” said Feng Zhang, senior author and James, and Patricia Poitras Professor of Neuroscience at MIT.

“It’s been very exciting to integrate genetics, bioinformatics, biochemistry, and structural biology approaches in one study to understand this fascinating molecular system.”

Bacteria use a variety of defense strategies to fight off viral infection, and some of these systems have led to groundbreaking technologies, such as CRISPR-based gene editing.

Scientists win 2015 Nobel Prize for Chemistry for work on DNA repair

Circa 2015


“Their work has provided fundamental knowledge of how a living cell functions and is, for instance, used for the development of new cancer treatments,” the Royal Swedish Academy of Sciences said.

Thousands of alterations to a cell’s genome occur every day due to spontaneous changes and damage by radiation, free radicals and carcinogenic substances — yet DNA remains astonishingly intact.

To keep genetic materials from disintegrating, a range of molecular systems monitor and repair DNA, in processes that the three award-winning scientists helped map out.

Population genomic analysis of elongated skulls reveals extensive female-biased immigration in Early Medieval Bavaria

This extensive research actually details the possibility of unknown origins of these elongated human skulls which many think to this day are some form of exterrestial in origin or at the very least unknown in origin which actually nearly uproots most know origin stories.


Modern European genetic structure demonstrates strong correlations with geography, while genetic analysis of prehistoric humans has indicated at least two major waves of immigration from outside the continent during periods of cultural change. However, population-level genome data that could shed light on the demographic processes occurring during the intervening periods have been absent. Therefore, we generated genomic data from 41 individuals dating mostly to the late 5th/early 6th century AD from present-day Bavaria in southern Germany, including 11 whole genomes (mean depth 5.56×). In addition we developed a capture array to sequence neutral regions spanning a total of 5 Mb and 486 functional polymorphic sites to high depth (mean 72×) in all individuals. Our data indicate that while men generally had ancestry that closely resembles modern northern and central Europeans, women exhibit a very high genetic heterogeneity; this includes signals of genetic ancestry ranging from western Europe to East Asia. Particularly striking are women with artificial skull deformations; the analysis of their collective genetic ancestry suggests an origin in southeastern Europe. In addition, functional variants indicate that they also differed in visible characteristics. This example of female-biased migration indicates that complex demographic processes during the Early Medieval period may have contributed in an unexpected way to shape the modern European genetic landscape. Examination of the panel of functional loci also revealed that many alleles associated with recent positive selection were already at modern-like frequencies in European populations ∼1,500 years ago.

Cedars-Sinai Creates Computer Models of Brain Cells

Realistic and complex models of brain cells, developed at Cedars-Sinai with support from our scientists and our #openscience data, could help answer questions a… See more.


Cedars-Sinai investigators have created bio-realistic and complex computer models of individual brain cells—in unparalleled quantity.

Their research, published today in the peer-reviewed journal Cell Reports, details how these models could one day answer questions about neurological disorders—and even human intellect—that aren’t possible to explore through biological experiments.

“These models capture the shape, timing and speed of the electrical signals that neurons fire in order to communicate with each other, which is considered the basis of brain function,” said Costas Anastassiou, PhD, a research scientist in the Department of Neurosurgery at Cedars-Sinai, and senior author of the study. “This lets us replicate brain activity at the single-cell level.”

The models are the first to combine data sets from different types of laboratory experiments to present a complete picture of the electrical, genetic and biological activity of single neurons. The models can be used to test theories that would require dozens of experiments to examine in the lab, Anastassiou said.

New Molecule Discovered That Strongly Stimulates Hair Growth

A team at the University of California, Irvine, has identified a signaling molecule that potently stimulates hair growth.

A signaling molecule known as SCUBE3, which was discovered by researchers at the University of California, Irvine, has the potential to cure androgenetic alopecia, a prevalent type of hair loss in both women and men.

The research, which was recently published in the journal Developmental Cell, uncovered the precise mechanism by which the dermal papilla cells, specialized signal-producing fibroblasts found at the bottom of each hair follicle, encourage new development. Although the critical role dermal papilla cells play in regulating hair growth is widely established, the genetic basis of the activating chemicals involved is little understood.

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https://www.jpost.com/health-and-wellness/article-714670 https://youtu.be/uc6f_2npsx8

The seeds of innovation appear to be seedless. According to game-changing research led by our very own Dr. Lior Rubinovich, it is now finally possible to grow avocado plants solely from tissue culture. Why is this good? Aside from being free of deformities, disease-proof, and significantly fast-growing – cultivated avocado plants mean genetic uniformity, which implies that all plants originate from the same delicious, nutritious, and healthy tissue. The founding of Bestree means a great deal for the northern region of Israel, both financially and innovatively. Therefore, we are proud to share this inspiring research with the rest of the world! Read more about Bestree & cultivated avocados in the full article https://www.ice.co.il/media/news/article/876527

האם ניתן לרבות שתילי אבוקדו בתרביות ריקמה? עד לפני כמה חודשים התשובה הייתה: “אולי, אבל טרם הצלחנו להבין כיצד לעשות זאת” היום התמונה היא אחרת, בעקבות מחקרו פורץ הדרך של ד“ר ליאור רובינוביץ’ הפך אבוקדו שמיוצר בתרבית ריקמה לרעיון שלא רק ניתן ליישמו במעבדה אלא גם למסחרו ולהביאו כבשורה לחקלאות העולמית! זהו פיתוחה וחזונה של חב’ Bestree אשר הוקמה על בסיס מחקרו של רבינוביץ’ ונחנכה בטקס חגיגי בקיבוץ אל-רום שבגליל. מעבר ליתרונות השיווקיים והכלכליים של המהלך – הקמתה של חב’ Bestree שמה את מיגל בשורה הראשונה של מכוני מחקר בעולם ובכך מקדמת גם את הפיתוח וההתחדשות החקלאית והמדעית של צפון מדינת ישראל! לחצו לקריאה מורחבת אודות חב’ Bestree https://www.ice.co.il/media/news/article/876527


Music video by Styx performing Mr. Roboto. © 1983 A&M Records.

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Researchers discover one of the largest known bacteria-to-animal gene transfers inside a fruit fly

A fruit fly genome is not a just made up of fruit fly DNA—at least for one fruit fly species. New research from the University of Maryland School of Medicine’s (UMSOM) Institute for Genome Sciences (IGS) shows that one fruit fly species contains whole genomes of a kind of bacteria, making this finding the largest bacteria-to-animal transfer of genetic material ever discovered. The new research also sheds light on how this happens.

The IGS researchers, led by Julie Dunning Hotopp, Ph.D., Professor of Microbiology and Immunology at UMSOM and IGS, used new genetic long-read sequencing technology to show how genes from the bacteria Wolbachia incorporated themselves into the fly genome up to 8,000 years ago.

The researchers say their findings show that unlike Darwin’s finches or Mendel’s peas, isn’t always small, incremental, and predictable.

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