Researchers from the Chinese Academy of Sciences (CAS) claim to have found a novel technique for programmable chromosome fusion successfully producing mice with genetic changes that…
Category: genetics – Page 231
Foresight Existential Hope Group.
Program & apply to join: https://foresight.org/existential-hope/
In the Existential Hope-podcast (https://www.existentialhope.com), we invite scientists to speak about long-termism. Each month, we drop a podcast episode where we interview a visionary scientist to discuss the science and technology that can accelerate humanity towards desirable outcomes.
Xhope Special with Foresight Fellow Morgan Levine.
Morgan Levine is a ladder-rank Assistant Professor in the Department of Pathology at the Yale School of Medicine and a member of both the Yale Combined Program in Computational Biology and Bioinformatics, and the Yale Center for Research on Aging. Her work relies on an interdisciplinary approach, integrating theories and methods from statistical genetics, computational biology, and mathematical demography to develop biomarkers of aging for humans and animal models using high-dimensional omics data. As PI or co-Investigator on multiple NIH-, Foundation-, and University-funded projects, she has extensive experience using systems-level and machine learning approaches to track epigenetic, transcriptomic, and proteomic changes with aging and incorporate.
this information to develop measures of risk stratification for major chronic diseases, such as cancer and Alzheimer’s disease. Her work also involves development of systems-level outcome measures of aging, aimed at facilitating evaluation for geroprotective interventions.
Existential Hope.
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Researchers at Washington University School of Medicine in St. Louis have found a new druggable pathway that potentially could be used to help prevent Alzheimer’s dementia.
Amyloid beta accumulation in the brain is the first step in the development of Alzheimer’s dementia. Scientists have poured countless hours and millions of dollars into finding ways to clear amyloid away before cognitive symptoms arise, with largely disappointing results.
In this study, published Aug. 24 in the journal Brain, researchers found a way to increase clearance of waste products from the brains of mice by ramping up a genetic quirk known as readthrough. This same strategy also may be effective for other neurodegenerative diseases characterized by the buildup of toxic proteins, such as Parkinson’s disease, the researchers said.
Basically this means halting and controlling cellular death which would reverse the death process :3.
During pyroptosis, gasdermin D (GSDMD) forms plasma membrane pores that initiate cell lysis. Here, the authors develop optogenetically activatable human GSDMD to assess GSDMD pore behavior and show that they are dynamic and can close, which can be a pyroptosis regulatory mechanism.
E-Project
Posted in biotech/medical, genetics, internet
“These results will have future implications in forensic medicine and genetic diagnosis.”
In 1999, François Brunelle, a Canadian artist, and photographer, began documenting look-alikes in a picture series “I’m not a look-alike!”
The project, undoubtedly, was a massive hit on social media and other parts of the internet, but it also drew the attention of scientists who study genetic relationships.
TABLE OF CONTENTS —————
0:00–15:11 : Introduction.
15:11–36:12 CHAPTER 1: POSTHUMANISM
a. Neurotechnology b. Neurophilosophy c. Teilhard de Chardin and the Noosphere.
TWITTER https://twitter.com/Transhumanian.
PATREON https://www.patreon.com/transhumania.
BITCOIN 14ZMLNppEdZCN4bu8FB1BwDaxbWteQKs8i.
BITCOIN CASH 1LhXJjN4FrfJh8LywR3dLG2uGXSaZjey9f.
ETHEREUM 0x1f89b261562C8D4C14aA01590EB42b2378572164
LITECOIN LdB94n8sTUXBto5ZKt82YhEsEmxomFGz3j.
CHAINLINK 0xDF560E12fF416eC2D4BAECC66E323C56af2f6666.
POSTHUMAN TECHNOLOGY
36:12–54:39 CHAPTER 2 : TELEPATHY/ MIND-READING
a. MRI
b. fMRI
c. EEG
d. Cognitive Liberty e. Dream-recording, Dream-economies f. Social Credit Systems g. Libertism VS Determinism.
1:02:07–1:25:48 : CHAPTER 3 : MEMORY/ MIND-AUGMENTING
a. Memory Erasure and Neuroplasticity b. Longterm Potentiation (LTP/LTD)
c. Propanolol d. Optogenetics e. Neuromodulation f. Memory-hacking g. Postmodern Dystopias h. Total Recall, the Matrix, and Eternal Sunshine of the Spotless Mind i. Custom reality and identity.
1:25:48–1:45:14 CHAPTER 4 : BCI/ MIND-UPGRADING
All around smart guy Dr Goerge Church talking about genetic engineering technologies.
George Church, Ph.D. is a professor of genetics at Harvard Medical School and of health sciences and technology at both Harvard and the Massachusetts Institute of Technology. Dr. Church played an instrumental role in the Human Genome Project and is widely recognized as one of the premier scientists in the fields of gene editing technology and synthetic biology.
EPISODE LINKS:
Show notes and transcript: https://www.foundmyfitness.com/episodes/george-church.
Dr. George Church on Twitter: https://twitter.com/geochurch.
Dr. George Church on Instagram: https://www.instagram.com/george.church.
Church lab: https://arep.med.harvard.edu/
Regenesis Book: https://www.amazon.com/Regenesis-Synthetic-Biology-Reinvent-…atfound-20
PODCAST INFO:
Email: https://www.foundmyfitness.com/newsletter.
Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322
Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d.
RSS: https://podcast.foundmyfitness.com/rss.xml.
CHAPTERS:
Reversal of aging
Posted in biotech/medical, genetics, life extension
Aging is a complex and inevitable process that affects all organisms – and it is associated with tissue dysfunction, susceptibility to various diseases, and death [1]. The development of strategies like cellular reprogramming for increasing the duration of healthy life and promoting healthy aging is difficult since the mechanism of aging is not understood clearly. Aging is known to be associated with several hallmarks of aging – such as epigenetic alterations, genomic instability, cellular senescence, telomere shortening, mitochondrial dysfunction and altered intercellular communication.
Aging can be divided into two major phases: healthy aging and pathological aging. Healthy aging is the phase where the accumulation of minor alterations takes place, but pathological aging is the phase where clinical diseases and disabilities predominate along with the impairment of physiological functions [2].
Longevity. Technology: Notions regarding cells undergoing a unidirectional differentiation process during development existed previously [3]. However, in recent years cellular reprogramming using transcription factors has emerged as an important strategy for the rejuvenation of aging cells, erasing markers of cell damage and restoring epigenetic markers. These transcription factors also known as Yamanaka factors include Oct4, Sox2, Klf4, and c-Myc (OSKM). They can convert terminally differentiated somatic cells into pluripotent stem cells which are capable of dividing into any cell type of the body and thus can improve the health and longevity of individuals.
Scientists have long sought to untangle the mystery of how aging links to increased risk of heart disease, a predominant killer of our time. It’s a tough problem: many biological aspects, spanning nature to nurture, can subtly influence heart health. To untangle the mystery, some experiments have lasted over half a century and scaled to hundreds of thousands of people.
The good news? We’ve got clues. With age, heart cells drastically change their function, eventually struggling to contract and release. A new study published in Nature Aging looked deep into genetic code to unravel why this happens.
Starting with a dozen volunteers spanning 0 to 82 years old, the team sequenced the entire genome of 56 heart muscle cells, or cardiomyocytes. The result is the first landscape painting of genetic changes in the aging heart. As we age, the heart gets hit with a double whammy at the DNA level. Cells’ genetic code physically breaks down, while their ability to repair DNA erodes.
A collection of photos of genetically unrelated look-alikes, along with DNA analysis, revealed that strong facial similarity is associated with shared genetic variants. The work appears August 23 in the journal Cell Reports.
“Our study provides a rare insight into human likeness by showing that people with extreme look-alike faces share common genotypes, whereas they are discordant at the epigenome and microbiome levels,” says senior author Manel Esteller of the Josep Carreras Leukemia Research Institute in Barcelona, Spain. “Genomics clusters them together, and the rest sets them apart.”
The number of people identified online as virtual twins or doubles who are genetically unrelated has increased due to the expansion of the World Wide Web and the possibility of exchanging pictures of humans across the planet. In the new study, Esteller and his team set out to characterize, on a molecular level, random human beings that objectively share facial features.