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Category: genetics – Page 229

Cellular senescence plays a significant role in cerebral tumors

Glioblastomas are the most common malignant tumors of the adult brain. They resist conventional treatment, including surgery, followed by radiation therapy and chemotherapy. Despite this armamentarium, glioblastomas inexorably recur.

In a new study published in Nature Communications, Isabelle Le Roux (CNRS) and her colleagues from the “Genetics and development of brain tumors” team at Paris Brain Institute have shown that the elimination of senescent cells, i.e., cells that have stopped dividing, can modify the tumor ecosystem and slow its progression. These results open up new avenues for treatment.

Glioblastoma, the most common adult brain cancer, affects 2 to 5 in 100,000 individuals. While the incidence of the disease is highest in those between 55 and 85 years old, it is increasing in all age groups. This effect can’t be attributed to improved diagnostic techniques alone, suggesting the influence of environmental factors hitherto unidentified.

Dr. Abdelali Haoudi, PhD — KAIMRC — Advancing Biomedical R&D & Clinical Development In Saudi Arabia

Advancing Biomedical R&D & Clinical Development In Saudi Arabia — Dr. Abdelali Haoudi, Ph.D., Managing Director, Biotechnology Park, King Abdullah International Medical Research Center, Ministry of National Guard Health Affairs.

Dr. Abdelali Haoudi, Ph.D. (https://kaimrc-biotech.org.sa/dr-abdelali-haoudi/) currently leads Strategy and Business Development functions, and is also Managing Director of the Biotechnology Park, at King Abdullah International Medical Research Center, at the Ministry of National Guard Health Affairs. He is also Distinguished Scholar at Harvard University-Boston Children’s Hospital.

Dr. Haoudi is an international Research & Development and Innovation Executive with over 25 years experience, having held several senior positions in Research and Development and Innovation. He has vast experience in science and technology policy development, strategy and business development, corporate development and international partnerships development.

Dr. Haoudi has held several senior and prestigious positions in the academia, government and private sectors globally, including North America, North Africa, Europe and Middle East. Some of the key positions include Founding Vice President for Research, Executive Director for Biomedical Research Institute, and Chairman, at the National Research Fund at Qatar Foundation.

Dr. Haoudi was also Research Professor of cancer and infectious diseases at the University of Virginia and Eastern Virginia Medical School and a fellow of the US National Institutes of Health (NIH). He has held several other positions in elite research and education institutions including Visiting Professor at Harvard Medical School (USA) and a fellow at Institute Pasteur (France).

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Epigenetic and social factors both predict aging and health, but new research suggests one might be stronger

Can we objectively tell how fast we are aging? With a good measure, scientists might be able to change our rate of aging to live longer and healthier lives. Researchers know that some people age faster than others and have been trying to concisely measure the internal physiological changes that lead to deteriorating health with age.

For years, researchers have been using clinical factors normally collected at physicals, like hypertension, cholesterol and weight, as indicators to predict aging. The idea was that these measures could determine whether someone is a fast or slow ager at any point in their . But more recently, researchers have theorized that there are other biological markers that reflect aging at the molecular and cellular level. This includes modifications to a person’s genetic material itself, or epigenetics.

While each person has a that largely does not change over their lifetime, to their genetic material that occur throughout life can change which genes are turned on or off and lead to more rapid aging. These changes typically involve the addition of methyl groups to DNA and are influenced by social and environmental exposures, such as , smoking, pollution and depression.

Telomeres Found To Encode Two Proteins, Potentially Transforming Cancer Research

Telomeres – the protective caps at the tips of chromosomes – can encode two proteins, something that was previously thought impossible, new research has suggested. The discovery of genetic information coding for these proteins, one of which is elevated in some human cancers, could have huge ramifications for the fields of health, medicine, and cell biology.

“Discovering that telomeres encode two novel signaling proteins will change our understanding of cancer, aging, and how cells communicate with other cells,” study author Jack Griffith, the Kenan Distinguished Professor of Microbiology and Immunology at the University of North Carolina at Chapel Hill, said in a statement.

“Based on our research, we think simple blood tests for these proteins could provide a valuable screen for certain cancers and other human diseases,” Griffith, who is also a member of the UNC Lineberger Comprehensive Cancer Center, added. “These tests also could provide a measure of ‘telomere health,’ because we know telomeres shorten with age.”

Study shows that distinct pyramidal cell types drive different patterns of cortical activity during decision-making

The outer layer of the brain, known as the cortex, is made of different types of neurons. Neuroscience studies suggest that these different neuron types have distinct functions, yet for a long time this was difficult to ascertain, due to the inability to examine and manipulate them in the brains of living beings.

In recent years, opened new possibilities for studying cells and their functions. Using some of these techniques, researchers at Forschungszentrum Jülich, RWTH Aachen University, Cold Spring Harbor Laboratory and other institutes in the United States closely examined the functions of different pyramidal cells, which are commonly found in the human cortex.

Their findings, published in Nature Neuroscience, suggest that distinct types of pyramidal cells drive patterns of cortical activity associated with different functions. The team’s study builds on some of their previous works focusing on in the cortex.

Scientists make stunning discovery, find new protein activity in telomeres

Once thought incapable of encoding proteins due to their simple monotonous repetitions of DNA, tiny telomeres at the tips of our chromosomes seem to hold a potent biological function that’s potentially relevant to our understanding of cancer and aging.

Reporting in the Proceedings of the National Academy of Sciences, UNC School of Medicine researchers Taghreed Al-Turki, Ph.D., and Jack Griffith, Ph.D., made the stunning discovery that telomeres contain to produce two small proteins, one of which they found is elevated in some human cells, as well as cells from patients suffering from telomere-related defects.

“Based on our research, we think simple blood tests for these proteins could provide a valuable screen for certain cancers and other human diseases,” said Griffith, the Kenan Distinguished Professor of Microbiology and Immunology and member of the UNC Lineberger Comprehensive Cancer Center. “These tests also could provide a measure of ‘telomere health,’ because we know telomeres shorten with age.”

This video explores Artificial Super Intelligence and how it will change the world

Watch this next video about the Future of Artificial Intelligence (2030 — 10,000 A.D.+): https://youtu.be/cwXnX49Bofk.
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SOURCES:
• Life 3.0: Being Human in the Age of Artificial Intelligence (Max Tegmark): https://amzn.to/3xrU351
• The Future of Humanity (Michio Kaku): https://amzn.to/3Gz8ffA
• The Singularity Is Near: When Humans Transcend Biology (Ray Kurzweil): https://amzn.to/3ftOhXI

Official Discord Server: https://discord.gg/R8cYEWpCzK
Patreon Page: https://www.patreon.com/futurebusinesstech.

💡 Future Business Tech explores the future of technology and the world.

https://youtu.be/cwXnX49Bofk.

Examples of topics I cover include:
• Artificial Intelligence & Robotics.
• Virtual and Augmented Reality.
• Brain-Computer Interfaces.
• Transhumanism.
• Genetic Engineering.

SUBSCRIBE: https://bit.ly/3geLDGO

Blood Test #1 in 2023: Diet Composition

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links:
NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout.

Green Tea: https://www.ochaandco.com/?ref=conqueraging.

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At-Home Blood Testing: https://getquantify.io/mlustgarten.

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REVERSE AGING — Sounds Too Good To Be True? | Dr David Sinclair Interview Clips

A couple minutes of your time for a little optimism.

Dr David Sinclair talks about no matter all the push backs and criticizes, he believes reverse aging therapy for human will be succeeded in this short clip.

David Sinclair is a professor in the Department of Genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, where he and his colleagues study sirtuins—protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction—as well as chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, cancer, and cellular reprogramming.

Dr David Sinclair has suggested that aging is a disease—and that we may soon have the tools to put it into remission—and he has called for greater international attention to the social, economic and political and benefits of a world in which billions of people can live much longer and much healthier lives.

Dr David Sinclair is the co-founder of several biotechnology companies (Life Biosciences, Sirtris, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others.

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