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Category: genetics – Page 227

Study reveals first genetic locus for voice pitch

In a paper published in Science Advances, an international team led by deCODE genetics, a subsidiary of Amgen, reveals the discovery of sequence variants in the gene ABCC9 that influence the pitch of voices.

Speaking is one of the most characteristic human behaviors, and yet the genetic underpinnings of voice and are largely unknown. In the first study of its kind, the scientists combined speech recordings from almost 13,000 Icelanders with data, in the sequence of the genome, to search for common variants in ABCC9 that are associated with a higher-pitched voice.

The scientists found that ABCC9 variants associate with higher voice pitch in both men and women. The same sequence variants are also linked to higher pulse pressure, a , highlighting links between voice pitch and health-related traits.

Researchers build on Human Genome Project advances

The Human Genome Project (HGP), the world’s largest collaborative biological project, was a 13-year effort led by the U.S. government with the goal of generating the first full sequence of the human genome. In 2003, HGP produced a genome sequence that accounted for more than 90% of the human genome and was considered as close to complete as was possible with the technologies of the time. HGP unlocked the door to a vast but unannotated collection of genes.

In the following decades, via experimental studies, researchers painstakingly curated reannotations in the form of biochemical reaction graphs. Though gene set enrichment analysis considers groups within these annotation graphs, it disregards group dependencies.

Researchers from the University of Hawaii at Mānoa John A. Burns School of Medicine (JABSOM) are utilizing data from HGP and making advancements in biochemical reaction network analysis. Their work, published in the May 22, 2023 issue of Patterns, demonstrates their approach and may help predict the effects of rare or indistinct genetic variations and guide precision medicine (treatment that can use a patient’s own to help fight disease or guide specific therapy).

Google Engineer Turned Futurist Predicts AI-Enabled Immortality For Humans

Former Google engineer and esteemed futurist Ray Kurzweil has made another bold prediction: Immortality is within reach for humans by 2030, thanks to the help of nanorobots. You read that right — humans could potentially live forever, according to Kurzweil.

Don’t Miss: Why Jason Calacanis and Other Silicon Valley Elites Are Betting On This Startups Vision For Re-Uniting American Families

Kurzweil, who has a track record of accurate predictions such as foreseeing a computer beating humans in chess by 2000, shared his prediction in a recent YouTube series by tech vlogger Adagio. The 75-year-old computer scientist believes that advancements in genetics, robotics and nanotechnology will allow tiny robots to run through veins, repairing any damage and keeping people alive indefinitely.

HsCRP: What’s Optimal, Which Factors May Reduce It?

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Revolutionary gene-editing therapy treats girl’s “incurable” cancer

A U.K. teen with an aggressive form of leukemia is now cancer-free, thanks to a new gene-editing therapy.

The particular therapy used on the patient was only invented six years ago, and it’s now making doctors rethink the way doctors approach the disease.

Mike Drolet reports on how the revolutionary technology works, and the possibilities it offers to change the lives of those with types of cancer long-thought to be incurable.

For more info, please go to https://globalnews.ca/news/9086170/sean-thomas-legacy-toy-drive-bc/

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“Genotoxic” Warning: Chemical Found in Common Sweetener Damages DNA

Sucralose, a widely used artificial sweetener, produces a DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Schooling substantially improves intelligence, but neither lessens nor widens the impacts of socioeconomics and genetics

Schooling, socioeconomic status (SES), and genetics all impact intelligence. However, it is unclear to what extent their contributions are unique and if they interact. Here we used a multi-trait polygenic score for cognition (cogPGS) with a quasi-experimental regression discontinuity design to isolate how months of schooling relate to intelligence in 6,567 children (aged 9–11). We found large, independent effects of schooling (β ~ 0.15), cogPGS (β ~ 0.10), and SES (β ~ 0.20) on working memory, crystallized (cIQ), and fluid intelligence (fIQ). Notably, two years of schooling had a larger effect on intelligence than the lifetime consequences, since birth, of SES or cogPGS-based inequalities. However, schooling showed no interaction with cogPGS or SES for the three intelligence domains tested.

Improving prostate cancer screening: accounting for genetic determinants of PSA variation

In a recent study published in Nature Medicine, researchers conducted a genome-wide analysis of prostate-specific antigen (PSA) levels of men without prostate cancer to understand the non-cancer-related variation in PSA levels to improve decision-making during the diagnosis of prostate cancer.

Study: Genetically adjusted PSA levels for prostate cancer screening. Image Credit: luchschenF/Shutterstock.com.

Resveratrol Extends Lifespan, But Only Under Two Experimental Conditions

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Engineering the bacteriophage T4 to serve as a vector for molecular repair

A team of medical scientists at The Catholic University of America, in Washington, D.C., working with a colleague from Purdue University, has developed a way to engineer the bacteriophage T4 to serve as a vector for molecular repair. The study is reported in the journal Nature Communications.

Prior research has shown that many human ailments arise due to : , Down syndrome, and hemophilia are just a few. Logic suggests that correcting such genetic mutations could cure these diseases. So researchers have been working toward developing gene editing tools that will allow for safe editing of genes.

One of the most promising is the CRISPR gene editing system. In this new effort, the research team took a more general approach to solving the problem by working to develop a vector that could be used to carry different kinds of tools to targeted cells and then enter them to allow for healing work to commence.

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