According to a recent study conducted by geneticists at the University of Pittsburgh School of Public Health in collaboration with several other organizations, including the University of Otago and the Samoan health research community, the discovery of a genetic variant that is relatively common among individuals of Polynesian descent but very rare in most other populations is providing clues to the genetic underpinnings of high cholesterol in all people.
Even worms have a ticking fertility clock. Older worms are less efficient at repairing broken DNA strands while making egg cells—part of a process that’s essential for fertility. A new study from University of Oregon (UO) biologists suggests one possible reason that reproduction slows with age.
Researchers from the lab of Diana Libuda report the findings in a paper published Nov. 7 in PLOS Genetics.
Each sperm or egg cell has only half the number of chromosomes found in a regular cell. During meiosis, the cell division process that forms sperm and eggs, the parent cells must evenly divide their DNA. The costs of error can be high, since incorrectly divided chromosomes are a major cause of birth defects.
Genetically engineering humans is a controversial topic. Some people believe that it is unethical, while others believe that it could be beneficial to humanity. There are pros and cons to both sides of the argument, and it is important to consider all of them before making a decision whether we should be genetically engineering humans or not.
In a breakthrough study, Japanese researchers at Osaka Metropolitan University have engineered the smallest motile life form ever. They introduced seven bacterial proteins into a synthetic bacterium, allowing it to move independently.
The rise of synthetic biology.
The new study is based on the synthetic bacterium called syn-3. The tiny spherical bacteria contain minimal genetic information, allowing them to grow and divide without motility.
The team experimented with syn-3 by introducing seven genes that code for proteins that are likely involved in the swimming motion of Spiroplasma bacteria.
UA/Wikimedia Commons.
A lot of anti-ageing vids lately. Good. This concerns Turn.bio. Though not in this vid, MH does have a habit of asking ‘When?” at some point. Previously Turn.bio said they have a first working treatment in just a few years so we’ll see what happens in vids to come of this interview.
In this video Professor Sebastiano introduces ERA, Epigenetic Reprogramming of Age technology and talks about his thoughts on some of the causes of aging.
Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview.
Turn Bio website.
https://www.turn.bio/
Professor Sebastiano’s lab at Stanford.
https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html.
Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.
https://pubmed.ncbi.nlm.nih.gov/32210226/
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The announcement comes from the journal Science, which published Phase 1 results of a small clinical trial for a vaccine technology that aims to cause the body to create a rare kind of cell.
“At the most general level, the trial results show that one can design vaccines that induce antibodies with pre-specified genetic features, and this may herald a new era of precision vaccines,” William Schief, PhD, a researcher at The Scripps Research Institute and study co-author, told the American Association for the Advancement of Science (AAAS).
The study was the first to test the approach in humans and was effective in 97% – or 35 of 36 – participants. The vaccine technology is called “germline targeting.” Trial results show that “one can design a vaccine that elicits made-to-order antibodies in humans,” Schief said in a news release.
This is a followup trial result to the first trial that reported 2.5 years of epigenetic age reversal This has interesting reports from the actual patients about how they feel and the changes it made to them. After the first trial I sent an email to see if I could do this but I have IBS which Fahy said would disqualify me.
Dr. Greg Fahy gives an update on the TRIIM-X clinical trial at EARD 2022.
The TRIIM-X clinical trial aims to understand how to create a personalized thymus regeneration regimen. By regenerating the thymus, the researchers hope to be able to prevent or reverse certain aspects of immune system aging.
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A gene linked to autism spectrum disorders plays a critical role in early brain development and may shape the formation of both normal and atypical nerve connections in the brain, according to a new study by Weill Cornell Medicine investigators.
The study, published Nov. 28 in Neuron, employed a combination of sophisticated genetic experiments in mice and analysis of human brain imaging data to better understand why mutations in a gene called Gabrb3 are linked to a high risk of developing autism spectrum disorder (ASD) and a related condition called Angelman Syndrome. Both conditions involve abnormal behaviors and unusual responses to sensory stimuli, which appear to stem, at least in part, from the formation of atypical connections between neurons in the brain.
“Neuron al connections in the brain, and developmental synchronization of neuronal networks, are perturbed in individuals with autism spectrum disorders, and there are specific genes that are implicated in the pathogenesis of ASD,” said co-first author Dr. Rachel Babij, a former student in the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-Ph. D. program in the laboratory of Natalia De Marco García, an associate professor in the Feil Family Brain and Mind Research Institute at Weill Cornell Medicine.