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Exercise Timing Is Associated With All-Cause Mortality Risk

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Discount Links:
NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout.

Green Tea: https://www.ochaandco.com/?ref=conqueraging.

Oral Microbiome: https://www.bristlehealth.com/?ref=michaellustgarten.

Epigenetic Testing: https://bit.ly/3Rken0n.
Use Code: CONQUERAGING!

At-Home Blood Testing: https://getquantify.io/mlustgarten.

Review highlights the effectiveness of diet-based low-density lipoprotein lowering over medication

In a recent article published in the journal Nutrition, researchers in Australia summarized how diet could help decrease low-density lipoprotein cholesterol (LDLc) or triglyceride concentrations in polygenic hypercholesterolemia.

Study: A Review of Low-Density Lipoprotein-Lowering Diets in the Age of Anti-Sense Technology. Image Credit: Ralwell / Shutterstock.

Elevated LDLc or dyslipidemia, including high levels of total cholesterol, increases the risk of cardiometabolic disorders and cardiovascular diseases (CVDs), especially ischemic heart disease (IHD), if not managed in time. Pharmacological treatment is sometimes a prerequisite for cases with complex dyslipidemia with a genetic component. Subsequently, pharmacological research yielded several highly effective drugs based on monoclonal antibody (mAb) therapy, some of which researchers even reviewed in this paper.

NAD Test #2: Impact of NMN?

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhD

Discount Links:
NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout.

Green Tea: https://www.ochaandco.com/?ref=conqueraging.

Oral Microbiome: https://www.bristlehealth.com/?ref=michaellustgarten.

Epigenetic Testing: https://bit.ly/3Rken0n.
Use Code: CONQUERAGING!

At-Home Blood Testing: https://getquantify.io/mlustgarten.

Determining the tempo of evolution across species

Scientists from Denmark and China have estimated germline mutation rates across vertebrates by sequencing and comparing genetic samples from 151 mother, father, and offspring trios from 68 species of mammals, fishes, birds and reptiles. A bioinformatics pipeline was designed to read, analyze and compare the genome mutations that occur yearly and between generations in each species.

The research was published March 1, 2023, in the journal Nature.

Knowing the germline mutation rate could allow a greater understanding of evolutionary drivers and be used to estimate when a species first arose. Despite the variety of evolutionary paths seen in 68 different species, researchers found the germline mutation rate to be relatively conserved.

George Church: Biomanufacturing, CRISPR,1 million cell edits, Woolly mammoth-Learning with Lowell-164

George Church is a geneticist known for his pioneering work in developing new technologies for genome sequencing, editing, and synthesis. He has also been involved in research on genome engineering and gene therapy.

Links.

George Church, Ph.D.


https://arep.med.harvard.edu/

PODCAST INFO:
The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson-is a lifelong autodidact, serial problem solver, and founder of startups.

LINKS
Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q
Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA
Linkedin: https://www.linkedin.com/in/lowell-thompson-2227b074
Twitter: https://twitter.com/LWThompson5
Website: https://www.learningwithlowell.com/

Timestamp / show notes.
00:00 Intro.
00:40 Changing millions of lives.
01:35 Unknowns in Biology / Fan question.
04:30 Space / Aliens.
05:18 Exciting projects.
08:15 Sequencing 8 billion people.
10:25 Making Organisms Virus proof.
12:00 Viruses adapting to changing.
15:55 Making IP actionable.
18:25 Transition to startups / issues.
22:30 Longevity and healthspan for older populations.
27:20 Rejuvenation vs cure.
29:40 Last 5 years/ surprises.
33:10 1 million cell edits.
34:40 Reduced returns with more edits at one time.
38:20 Software as biology / opportunity in biotech.
41:35 Hiding data in cells.
43:40 Synthetic biology relieving poverty.
47:45 Biohacking, chinese box, relieving poverty continues.
50:53 Producing good/submarine.
53:25 Synthetic biology for energy production.
57:51 Wooly mammoth genes / fan q.
1:02:30 Control characteristics with food.
1:03:50 Expediting gestation period.
1:06:00 External womb.
1:08:55 Problems /tools he wishes he had.
1:12:25 Cost of gene therapies from rejuvenation bio / fan question.
1:18:22 Virus gene drive.
1:21:10 Next 10 years.
1:23:02 CIRSPR CRPS pain question.
1:26:33 Books.
1:32:42 Calico lab CTO?

#georgechurch #syntheticbiology #biomanufacturing

Reversed With a Single Drug — “Incurable” Liver Disease May Be Curable

A new study from Sanford Burnham Prebys has discovered a drug that can spur liver regeneration in patients with Alagille syndrome.

For the first time, research conducted by Associate Professor Duc Dong, Ph.D. has revealed that the detrimental effects of Alagille syndrome, a genetic disorder that has no cure, can be reversed using a single drug. The findings, published in the Proceedings of the National Academy of Sciences, have the potential to revolutionize the treatment approach for this rare condition, and could also shed light on more widespread diseases.

“Alagille syndrome is widely considered an incurable disease, but we believe we’re on the way to changing that,” says Dong, who is also the associate dean of admissions for Sanford Burnham Prebys’ graduate school. “We aim to advance this drug into clinical trials, and our results demonstrate its effectiveness for the first time.”

Long-Puzzling Biologists: Cornell Study Reveals How Cells Prevent Harmful Extra DNA Copies

According to a recent study by researchers at Weill Cornell Medicine, a protein that prepares DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Small differences in mom’s behavior may show up in child’s epigenome

Adding evidence to the importance of early development, a new study links neutral maternal behavior toward infants with an epigenetic change in children related to stress response.

Epigenetics are molecular processes independent of DNA that influence gene behavior. In this study, researchers found that neutral or awkward behavior of mothers with their babies at 12 months correlated with an epigenetic change called methylation, or the addition of methane and carbon molecules, on a gene called NR3C1 when the children were 7 years old. This gene has been associated with regulating the body’s response to stress.

“There is evidence of a relationship between the quality of maternal-infant interaction and methylation of this gene though these are small effects in response to a relatively small variation in interaction,” said Elizabeth Holdsworth, a Washington State University biological anthropologist and lead author of the study published in the American Journal of Human Biology.

Researchers provide proof of the helical coiling of condensed chromosomes

The iconic X-shaped organization of metaphase chromosomes is frequently presented in textbooks and other media. The drawings explain in captivating manner that the majority of genetic information is stored in chromosomes, which transmit it to the next generation. “These presentations suggest that the chromosome ultrastructure is well-understood. However, this is not the case,” says Dr. Veit Schubert from IPK’s chromosome structure and function research group.

Several models have been proposed to describe the higher-order structure of metaphase based on data obtained using a range of molecular and microscopy methods. These models are categorized as helical and non-helical. Helical models assume that the chromatin in each sister chromatid at metaphase is arranged as a coil, whereas non-helical models suggest that chromatin is folded within the chromatids without forming a spiral.

The researchers revived the term “chromonema,” which was used for the first time at the beginning of the 20th century. Now, the IPK and IEB researchers provided a detailed description of its ultrastructure. Different experimental approaches, including chromosome conformation capture sequencing (Hi-C) of isolated mitotic chromosomes, polymer modeling, and microscopic observations of sister chromatid exchanges and oligo-FISH labeled regions at the super-resolution level provided an independent proof for the coiling of the chromonema.