Lifeboat Foundation

Aging remains a primary risk factor for a host of diseases, including leading causes of death. Aging and associated diseases are inherently multifactorial, with numerous contributing factors and phenotypes at the molecular, cellular, tissue, and organismal scales. Despite the complexity of aging phenomena, models currently used in aging research possess limitations. Frequently used in vivo models often have important physiological differences, age at different rates, or are genetically engineered to match late disease phenotypes rather than early causes. Conversely, routinely used in vitro models lack the complex tissue-scale and systemic cues that are disrupted in aging.

A study published Wednesday in the JAMA Psychiatry journal shows that four key genetic variations are more common in military veterans who have taken their own life or considered it.

Scientists from Duke University in Durham, North Carolina, found the pattern while analyzing blood samples from a database that included 633,778 U.S. veterans, cross-referenced with the International Suicide Genetics Consortium of more than 549,000 individuals.

The obtained samples were sequenced to create genetic profiles compared to participants’ medical records, showing that 121,211 recorded cases of attempted suicide or thoughts about killing themselves.

The entire DNA of 100,000 newborns in England will be sequenced to spot rare genetic conditions early.

Year 2020 face_with_colon_three

Scientists are working to end the need for human heart transplants by 2028. A team of researchers in the UK, Cambridge, and the Netherlands are developing a robot heart that can pump blood through the circulatory network but is soft and pliable. The first working model should be ready for implantation into animals within the next 3 years, and into humans within the next 8 years. The device is so promising that it is among just 4 projects that have made it to the shortlist for a £30-million prize, called the Big Beat Challenge for a therapy that can change the game in the treatment of heart disease.

The other projects include a genetic therapy for heart defects, a vaccine against heart disease, and wearable technology for early preclinical detection of heart attacks and strokes.

Continue reading “Robotic heart to replace human transplants on the horizon” »

In the underground movement known as, people are taking their health into their own hands. Biohacking ranges from people making simple lifestyle changes to extreme body modifications.

One popular form of focuses on nutrigenomics, where biohackers study how the foods they eat affect their genes over time. They believe they can map and track the way their diet affects genetic function. They use dietary restrictions and blood tests, while tracking their moods, energy levels, behaviors, and cognitive abilities.

Continue reading “I got a chip implanted in a biohacking garage” »

Huntington’s disease (HD) is a neurological disorder that causes progressive loss of movement, coordination and cognitive function. It is caused by a mutation in a single gene called huntingtin (HTT). More than 200,000 people worldwide live with the genetic condition, approximately 30,000 in the United States. More than a quarter of a million Americans are at risk of inheriting HD from an affected parent. There is no cure.

But in a new study, published December 12, 2022 in Nature Neuroscience, researchers at University of California San Diego School of Medicine, with colleagues elsewhere, describe using RNA-targeting CRISPR/Cas13D technology to develop a new therapeutic strategy that specifically eliminates toxic RNA that causes HD.

CRISPR is known as a genome-editing tool that allows scientists to add, remove or alter genetic material at specific locations in the genome. It is based on a naturally occurring immune defense system used by bacteria. However, current strategies run the risk of off-target edits at unintended sites that may cause permanent and inheritable chromosomal insertions or genome alterations. Because of this, significant efforts have focused on identifying CRISPR systems that target RNA directly without altering the genome.

An international research team led by Dr. Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

Patients with mutations in this protein suffer from Allan-Herndon-Dudley syndrome, a rare disease that takes the form of serious neurological alterations, in which each patient may reveal a different mutation of MCT8.

This study, published in Neurobiology of Disease, describes the first avatar model for the disease—in other words, the first animal model with the same genetic alteration as various patients.

These genetically engineered plants can take over the work of 30 houseplants.

A bioengineered plant is able to clean the air by doing the work of over 30 houseplantsIt could be the start of a bold new industry that develps over the next 15 to 20 years.

The Neo P1 is the first of its kind.

Continue reading “Plant-based air purifiers are coming to your home — The Blueprint” »

Northwestern University researchers have discovered a previously unknown mechanism that drives aging.

In a new study, researchers used artificial intelligence to analyze data from a wide variety of tissues, collected from humans, mice, rats and killifish. They discovered that the length of genes can explain most molecular-level changes that occur during aging.

All cells must balance the activity of long and short genes. The researchers found that longer genes are linked to longer lifespans, and shorter genes are linked to shorter lifespans. They also found that aging genes change their activity according to length. More specifically, aging is accompanied by a shift in activity toward short genes. This causes the gene activity in cells to become unbalanced.