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Category: chemistry – Page 23

Oil cleanup agents do not impede natural biodegradation, research reveals

Using spill-treating agents to clean up oil spills does not significantly hinder naturally occurring oil biodegradation, according to a new study. The research, published in Applied and Environmental Microbiology, provides information that will be useful in future oil spills.

Biodegradation is an incredibly important natural process when it comes to . A significant portion of the oil can be permanently removed from the contaminated area through . On-scene coordinators and other first responders must weigh the benefits against potential risks of any response action, such as using spill-treating agents. Emergency response actions to vary widely depending on the scale of an oil spill, location and environmental conditions.

Different treating agents serve different functions. Oil dispersants break the oil into smaller droplets. Surface washing agents lift stranded oil from solid substrates. Chemical herders corral oil into a thicker slick to ease mechanical removal and can also enhance burning efficiency.

Scientists finally confirm vitamin B1 hypothesis from 1958

Chemists have confirmed a 67-year-old theory about vitamin B1 by stabilizing a reactive molecule in water—a feat long thought impossible. The discovery not only solves a biochemical mystery, but also opens the door to greener, more efficient ways of making pharmaceuticals.

The molecule in question is a carbene, a type of carbon atom with only six valence electrons. Generally, carbon is stable with eight electrons around it. With only six electrons, it is chemically unstable and highly reactive. In water, it usually decomposes instantly. But for decades, scientists have suspected that vitamin B1, also known as thiamine, may form a carbene-like structure in our cells to carry out vital reactions in the body.

Now, for the first time, researchers have not only generated a stable carbene in water, they’ve also isolated it, sealed it in a tube, and watched it stay intact for months. This discovery is documented in a paper published last week in Science Advances.

Engineering a hydrogen-bonding microenvironment to boost CO₂ electroreduction

Catalytic conversion of waste CO2 into value-added fuels and chemicals offers unprecedented opportunities for both environmental protection and economic development. Electrocatalytic CO2 reduction reaction (CO2RR) has garnered significant attention for its ability to efficiently convert CO2 into clean chemical energy under mild conditions. However, the relatively high energy barrier for *COOH intermediate formation often becomes the determining step in CO2RR, significantly limiting reaction efficiency.

Inspired by , a team led by Prof. Jiang Hai-Long and Prof. Jiao Long from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) developed a novel strategy to stabilize *COOH intermediate and enhance electrochemical CO2 reduction by constructing and modulating the hydrogen-bonding microenvironment around catalytic sites. Their work is published in the Proceedings of the National Academy of Sciences.

In this work, the team co-grafted catalytically active Co(salen) units and proximal pyridyl-substituted alkyl (X-PyCn) onto Hf-based MOF nanosheets (MOFNs) via a post decoration route, affording Co&X-PyCn/MOFNs (X = o, m or p representing the ortho-, meta-, or para-position of pyridine N relative to alkyl chain; n = 1 or 3 representing the carbon atom number of alkyl chains) materials.

Unlocking the secrets of salt crystal formation at the nanoscale

In nature and technology, crystallization plays a pivotal role, from forming snowflakes and pharmaceuticals to creating advanced batteries and desalination membranes. Despite its importance, crystallization at the nanoscale is poorly understood, mainly because observing the process directly at this scale is exceptionally challenging. My research overcame this hurdle by employing state-of-the-art computational methods, allowing them to visualize atomic interactions in unprecedented detail.

Published in Chemical Science, my research has uncovered new details about how salt crystals form in tiny nanometer-sized spaces, which could pave the way for and improved electrochemical technologies.

This research used sophisticated enhanced by cutting-edge machine learning techniques to study how (NaCl), common table salt, crystallizes when confined between two graphene sheets separated by just a few billionths of a meter. These , known as nano-confinement, drastically alter how molecules behave compared to bulk, everyday conditions.

Light-activated probe reveals how tuberculosis evades immune defenses

Tuberculosis (TB) is an infectious disease that kills more than a million people worldwide every year. The pathogen that causes the disease, Mycobacterium tuberculosis, is deadly in part because of its complex outer envelope, which helps it evade immune responses of infected hosts.

In an ACS Infectious Diseases paper, researchers developed a chemical probe to study a key component of this envelope. Their results provide a step toward finding new ways of inactivating the bacterium.

Because curing TB requires taking drugs for months, which can result in TB resistance to some antibiotics, scientists are working to develop new treatments. One possible target is the bacterium’s outermost layer, called the mycomembrane, which protects the bacteria from stressors. When M. is attacked by a host’s macrophage , the mycomembrane produces compounds that suppress the infected host’s immune response.

Microtubules and the Prehistory of Mind: Toward a Cytoskeletal Epistemology

This essay advances a speculative yet empirically-grounded hypothesis: that microtubular cytoskeletal structures constitute proto-cognitive architectures in unicellular organisms, thereby establishing an evolutionary substrate for cognition that predates neural systems. Drawing upon converging evidence from molecular biology, quantum biophysics, phenomenological philosophy, and biosemiotic theory, I propose a cytoskeletal epistemology wherein cognition emerges not exclusively from neural networks, but from the dynamic, embodied information-processing capacities inherent in cellular organization itself. This framework challenges neurocentric accounts of mind while suggesting new avenues for investigating the biological foundations of knowing.

Contemporary cognitive science predominantly situates the genesis of mind within neural tissue, tacitly assuming that cognition emerges exclusively from the electrochemical dynamics of neurons and their synaptic interconnections. Yet this neurocentric paradigm, while experimentally productive, encounters both conceptual and empirical limitations when confronted with fundamental questions regarding the biological preconditions for epistemic capacities. As Thompson (2007) observes, “Life and mind share a set of basic organizational properties, and the organizational properties distinctive of mind are an enriched version of those fundamental to life” (p. 128). This suggests a profound continuity between biological and cognitive processes — a continuity that invites investigation into pre-neural substrates of cognition.

The present inquiry examines the hypothesis that the microtubule — a foundational cytoskeletal element ubiquitous across eukaryotic cells — functions not merely as mechanical infrastructure but as an evolutionary precursor to cognitive architecture, instantiating proto-epistemic capacities in unicellular and pre-neural multicellular organisms. This hypothesis emerges at the intersection of multiple research programs, including quantum approaches to consciousness (Hameroff & Penrose, 2014), autopoietic theories of cognition (Maturana & Varela, 1980), and recent advances in cytoskeletal biology (Pirino et al., 2022).

How Tiny Organisms Control Minds, Create Zombies, and Shape Ecosystems

Miniature zombies are all around us, scuttling through the underbrush or flying through the air in nearly every continent on Earth. In Brazil, a fungus takes over ant brains, altering their circadian rhythms and social behaviors. In England, a virus forces caterpillars to climb high into the canopy, then slowly liquefies their bodies, which drip onto the leaves below. In Indonesia, a parasitoid wasp uses specialized venom to alter a cockroach’s brain chemistry, turning it into the perfect host for her young.

In her new book, Rise of the Zombie Bugs, self-described professional science nerd Mindy Weisberger introduces readers to a menagerie of mind-controlling parasites, and the scientists who have devoted their lives to the study of these peculiar organisms. Through these vivid tales of creatures bizarre enough to rival any fictional beast, Weisberger offers readers a peek into the fields of evolution, ecology, neuroscience, and molecular biology. She shows that these topics exist beyond dim lecture halls and dry textbooks: “Science is everything and everywhere,” she said.

Detecting nanoplastics in body fluids: New method combines optofluidic force and Raman spectroscopy

Microplastics and much smaller nanoplastics enter the human body in various ways, for example through food or the air we breathe. A large proportion is excreted, but a certain amount remains in organs, blood, and other body fluids.

In the FFG bridge project Nano-VISION, which was launched two years ago together with the start-up BRAVE Analytics, a team led by Harald Fitzek from the Institute of Electron Microscopy and Nanoanalysis at Graz University of Technology (TU Graz) and an ophthalmologist from Graz addressed the question of whether nanoplastics also play a role in ophthalmology.

The project partners have now been able to develop a method for detecting and quantifying nanoplastics in transparent body fluids and determining their chemical composition. The research is published in the journal Analytical Chemistry.

CD36-mediated endocytosis of proteolysis-targeting chimeras

CD36 is identified as the membrane receptor for cellular uptake of PROTACs and other eRo5/bRo5 molecules. A chemical endocytic medicinal chemistry strategy to enhance the binding of PROTACs to CD36 improved the uptake and potency of PROTACs without sacrificing solubility or stability. This strategy could improve the bioavailability and potency of diverse endocytic drugs.

Solar cell efficiency record achieved with tin halide perovskite

University of Queensland researchers have set a world record for solar cell efficiency with eco-friendly perovskite technology. A team led by Professor Lianzhou Wang has unveiled a tin halide perovskite (THP) solar cell capable of converting sunlight to electricity at a certified record efficiency of 16.65%. The research is published in the journal Nature Nanotechnology.

Working across UQ’s Australian Institute for Bioengineering and Nanotechnology and the School of Chemical Engineering, Professor Wang said the certified reading achieved by his lab was nearly one percentage point higher than the previous best for THP solar cells.

“It might not seem like much, but this is a giant leap in a field that is renowned for delicate and incremental progress,” Professor Wang said.