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An experimental new type of cancer treatment has yielded some impressive results in mice: the eradication of advanced-stage ovarian and colorectal cancer in the animals as little as six days.

The new therapy has only been tested in mice so far, so let’s not get too excited just yet. However, the early signs are promising, and human clinical trials could be underway by the end of the year.

The treatment involves tiny ‘drug factory’ beads that are implanted into the body and deliver a continuous, high dose of interleukin-2 (IL2) – a natural compound that enlists white blood cells in the fight against cancer.

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Further research shows that the test is accurate.

When it comes to genetic neurological and neuromuscular diseases, screening early is key to getting the right treatment. A new DNA test developed by researchers at the Garvan Institute of Medical Research in Sydney may help in this process, as reported by the institution in a press release published on Saturday.

Garvan researchers have shown how new genomic sequencing technology can reduce the ‘diagnostic odyssey’ experienced by people with rare neurological and neuromuscular diseases.

Continue reading “Single test for over 50 genetic diseases will cut diagnosis from decades to days” »

(Part II) Centenarian Blood Test Analysis (n=1,754)

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Continue reading “Centenarian Blood Test Analysis (n=1,754; Part II)” »

Thanks to the work of squirrels, researchers in Siberia were able to grow viable Silene stenophylla plants from 32,000-year-old seeds. This incredible event, which happened in 2012, is still having a dramatic event on the scientific community and now Austrian researchers are trying to sequence the plant’s DNA to find out how it was able to survive so long.

The story starts over 10 years ago, when a team of Russian, Hungarian, and American scientists recovered the frozen seeds in 2007. They were buried 125 feet underground, deep in the Siberian permafrost. The team was investigating the burrows of ancient squirrels when they made the discovery. Fruit and seeds had been perfectly sealed from the elements thanks to the squirrels’ burrowing techniques.

“The squirrels dug the frozen ground to build their burrows, which are about the size of a soccer ball, putting in hay first and then animal fur for a perfect storage chamber,” shared Stanislav Gubin, one of the researchers who explored the burrows. “It’s a natural cryobank.”

Summary: 3,6’-dithiopomalidomide (DP), an anti-inflammatory drug candidate, protected mouse models of Alzheimer’s disease against cognitive decline by reducing neuroinflammation.

Source: NIH

An anti-inflammatory drug candidate, known as 3,6’-dithiopomalidomide (DP), designed by researchers at the National Institute on Aging (NIA), protected lab mice against cognitive decline by reducing brain inflammation.

Cancer, aging, and severe COVID-19 have all been linked to damage from inflammation. Now scientists are flipping their focus to find new drugs that may revolutionize treatments.

Biologists from ETH Zurich have discovered speargun-like molecular injection systems in two types of bacteria and have described their structure for the first time. The special nanomachines are used by the microbes for the interaction between cells and could one day be useful as tools in biomedicine.