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Category: biotech/medical – Page 894

DNA-programmed self-assembly leverages the chemical specificity of DNA hybridization to stabilize user-prescribed crystal structures1,2. Pioneering studies have demonstrated that DNA hybridization can guide the self-assembly of a wide variety of nanoparticle crystal lattices, which can grow to micrometer dimensions and contain millions of particles3,4,5,6,7,8,9. Attention has now turned toward the goal of assembling photonic crystals from optical-scale particles (i.e., roughly 100‑1000 nm in diameter)10,11,12 using DNA-programmed interactions. To this end, progress over the past decade has established that DNA can indeed program the self-assembly of bespoke crystalline structures from micrometer-sized colloidal particles13,14,15,16,17,18,19. However, growing single-domain crystals comprising millions of DNA-functionalized, micrometer-sized colloidal particles remains an unresolved barrier to the development of practical technologies based on DNA-programmed assembly. Prior efforts have yielded either single-domain crystals no more than a few dozen micrometers in size13,14,15,16 or larger polycrystalline materials with heterogeneous domain sizes12,15,17,20. These features—small crystal domains, polycrystallinity, and size dispersity—have therefore precluded the use of DNA-coated colloidal crystals in photonic metamaterial applications.

Assembling macroscopic materials from DNA-functionalized, micrometer-sized colloids is challenging due to the vastly different length scales between the DNA molecules and the colloidal particles (Fig. 1a). This combination leads to crystallization kinetics that are extremely sensitive to temperature and prone to kinetic trapping1,21,22,23. The resulting challenges are both practical and fundamental in nature. For example, recent work has shown that crystal nucleation rates can vary by orders of magnitude over a temperature range of only 0.25 °C19. Extremely precise temperature control would therefore be required to self-assemble single-domain crystals from a bulk solution (Fig. 1b). At the same time, annealing polycrystalline materials is difficult due to the combination of the short-range attraction and the friction arising from the DNA-mediated colloidal interactions, which slows the rolling and sliding of colloidal particles at crystalline interfaces15,19,24,25.

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USA: A cohort study of 3,058 patients with perioperative cardiac arrests showed that frailty is associated with increased mortality and nonhome discharge.

Increased Risk Analysis Index (RAI) among patients with severe frailty was tied to steadily increasing the risk of non-home discharge and mortality, and the association with mortality was most pronounced in the context of non-emergency surgery.

The findings of the cohort study, published in JAMA Network Open, suggest that although roughly 1 in 3 patients with an RAI of 40 or greater survived at least 30 days following perioperative CPR, higher frailty burden was associated with increased mortality and greater risk of non-home discharge among survivors.

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Dr. Ralph W. Moss and son Ben discuss how a walk in the woods may help manage symptoms and improve quality of life. Delve into the science behind how the Japanese practice of “Forest Bathing” and aromatherapy can reduce stress, improve mood, and ease pain.

Program Notes:

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5 Defenders Mushroom Blend.
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“A comprehensive self-help plan for cancer includes medicinal mushrooms. They are indispensable”. – Ralph W. Moss, PhD.

Continue reading “Essential Oils, Aromatherapy & Cancer — Fragrant Forest Bathing and Potent Pain Relief” | >

Researchers from the University of California, San Francisco and colleagues conducted a study to determine whether AKI is independently associated with subsequent kidney function trajectory among patients with chronic kidney disease (CKD). The findings suggest kidney disease observed after AKI often present before injury.

In the present study of hospitalized persons with chronic kidney disease (CKD) fournd that acute kidney injury (AKI) did not predict worsening of kidney function trajectory once difference in pre-hospitalization characteristically were fully accounted for. Instead, the authors suggest that much of determinants of faster kidney disease decline observed after AKI may already be present before AKI. The findings are published in Annals of Internal Medicine.

Many now believe that AKI is an independent risk factor for accelerated loss of kidney function. This has led to changes in research focus, practice patterns, and public health targets. However, prior studies associating AKI with more rapid subsequent loss of kidney function had methodological limitations, including inadequate control for differences between patients who had AKI and those who did not.

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A pair of new studies led by researchers at Columbia University explains why babies get so many common respiratory infections and identifies a specialized cluster of immune cells found only in babies that help them better cope with new pathogens.

“We know little about how the immune system develops throughout life, and most of what we know about immune system development in children comes from animal studies,” says Donna Farber, Ph.D., an expert in immune system development at Columbia University Vagelos College of Physicians and Surgeons who led the research. “But mice develop much more quickly than humans and their immune systems are a bit different than ours.”

Using a trove of tissue samples from deceased pediatric organ donors, Farber’s team was able to pinpoint aspects of development that distinguish babies from adults.

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Pain affects millions of Americans. It’s hard to measure, and there isn’t a one-size-fits-all treatment approach. NIH conducts and supports basic, translational, and clinical research on pain, as well as strategies for treating it. Here are just a few recent examples.

Basic pain research

Basic research is conducted in labs by scientists who study the most fundamental building blocks of life, including genes, proteins, and cells. This kind of research helps us better understand living systems and processes.

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Some sharks get a new set of teeth every few weeks, while crocodiles can go through thousands of chompers in their long lifetimes. Yet the ability to endlessly replace our pearly whites is something that’s eluded us and nearly all other mammals. By the time our 32 ‘adult’ teeth grow in, that’s as good as it gets.

Now, a Japanese team of scientists is set to trial an experimental drug that would allow humans to grow completely new teeth.

A clinical trial scheduled for July 2024 will initially be for participants with tooth agenesis, a genetic condition that results in the absence of teeth, but the scientists have a view to making the treatment available for general use by as soon as 2030.

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MicroNeuro ensures surgical safety and frees surgeons from labor-intensive tasks.

Today, less than 3 surgeries in the world are robot-assisted. The most common type of clinical robotic surgical system surgeons use includes a camera and mechanical arms with surgical instruments attached to them.

Robot assistance is known to provide more precision in brain surgeries than humans performing surgery, which may lead to damage to healthy tissues.

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Here’s my new Opinion essay at Newsweek. It’s about the need to use our nation’s massive natural resources to pay for a bipartisan tax free universal basic income, called the Federal Land Dividend. I hope you will read and share it!

In 2018, I began lecturing about the Federal Land Dividend, a bipartisan tax-free Universal Basic Income (UBI) based on monetizing the 640 million acres of mostly unused federally owned land. Due to the lasting effects of the coronavirus pandemic, which include a struggling U.S. economy, there is increasing interest in implementing basic income plans. The Federal Land Dividend is the only method that is both bipartisan and tax free.

An estimated 50 percent of the 11 most western states are mostly empty land that belong to the government. Estimates say this land and its resources are worth approximately $100 to $200 trillion. If we divide the middle— $150 trillion —by America’s population of 333 million, every person would have approximately $450,000 in equity. That’s much higher than the median net worth in America of $122,000.

The Federal Land Dividend aims to lease out land and natural resources to big business that agree, in exchange, to pay a monthly income to all Americans. It’s estimated that if just 60 percent of America’s unused federal land was leased out at fair rates, a $1,000 monthly check could be sent to all Americans—regardless of age—for decades if not centuries. Because land and raw materials often move in tandem with inflation, payouts could increase with inflation. Furthermore, this plan does not touch any national parks whatsoever. Much of this land is in places that few humans ever visit or see.

Some conservatives support the Federal Land Dividend idea because it will boost big business while providing an economic stimulus to all Americans. Some liberals also support the idea because it will dramatically help end poverty. Even some libertarians like the idea because it returns the value of federal land to the people, instead of the government hoarding and controlling it.

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Scientists at Harvard University claim to have come excitingly close to finding the proverbial Fountain of Youth. According to a recent publication in the scientific journal Aging, the team has identified six chemical concoctions that have the ability to reverse the aging process in both human and mice skin cells.

Dr. David Sinclair, a molecular biologist at Harvard Medical School and co-author of the study, has hailed this as a “breakthrough” and sees it as a step towards “affordable whole-body rejuvenation.”

Dr. Sinclair has even suggested that human trials could commence within the next year. This prediction has caught the attention of prominent figures, such as tech mogul Elon Musk. He responded to the news with curiosity asking, “Ok, so what exactly is it?”

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