Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 891

A robot that can shift between solid and liquid states has been filmed escaping from a miniature jail cell with bars too close together to allow it to leave in solid form. The creators claim they were inspired by sea cucumbers’ capacity to alter their tissue stiffness – but the scene is just a little too similar to Robert Patrick liquifying his way through the mental hospital bars for us to believe them. We even see the famous reabsorption of the little bit left behind.

Hard-bodied robots are common, even if they have yet to reach the capacities of science fiction films. Their soft-bodied counterparts can get into tight spaces, but what they can do there is limited, and they are also difficult to control.

A team led by Dr Chengfeng Pan of the Chinese University of Hong Kong has made a robot that can swap states to whichever is most needed, with a video that sums it up. The prison escape may trigger our fears, but robots like these could also provide lifesaving services others cannot.

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Novak Djokovic, age 35, sometimes hangs out in a pressurized egg to enrich his blood with oxygen and gives pep talks to glasses of water, hoping to purify them with positive thinking before he drinks them. Tom Brady, 45, evangelizes supposedly age-defying supplements, hydration powders and pliability spheres. LeBron James, 38, is said to spend $1.5 million a year on his body to keep Father Time at bay. While most of their contemporaries have retired, all three of these elite athletes remain marvels of fitness. But in the field of modern health science, they’re amateurs compared to Bryan Johnson.

Middle-aged tech centimillionaire Bryan Johnson and his team of 30 doctors say they have a plan to reboot his body.

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We spoke with Dr Morgan Levine 2 years ago concerning the remarkable results that she and a team that included Dr David Sinclair had in restoring vision in mice. In that experiment, published in the journal Nature, older mice had tighter optic nerves crushed causing blindness. Then, using a combination of 3 of the 4 Yamanaka cellular programing factors, they were able to restore the mice’s vision by signally the underlying DNA, rebuilding what had been thought to be permanently damaged cells. This was a remarkable result, as it was restoring a damaged organ, essentially a part of the brain, to its original healthy state. When I spoke to Dr Levine about the next step in her research, she mentioned it may be a more complex organ, such as a mouse liver.

But they went further. In the January issue of Cell, Sinclair published results of their ability to age an entire mouse. That is, to signal the epigenome to cause the underlying mouse DNA to behave as if it were much older. They were also able to do the reverse: to take an older mouse and, by signaling the epigenome, bring its cells and organs to the state of a younger mouse. This is a truly remarkable achievement, and it seems to prove Sinclair’s theory that all of our cells have within them a pristine copy of their DNA, and that aging and the disease associated with aging are the result of miscues from the epigenome. If these miscues can be corrected then the cell can be restored, not to a blank stem cell but to its original condition.

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You’ve seen the headlines. The FDA approved its use in tackling the underlying genetic mutation for sickle cell disease. Some researchers edited immune cells to fight untreatable blood cancers in children. Others took pig-to-human organ transplants from dream to reality in an attempt to alleviate the shortage of donor organs. Recent work aims to help millions of people with high cholesterol—and potentially bring CRISPR-based gene therapy to the masses—by lowering their chances of heart disease with a single injection.

But to Dr. Jennifer Doudna, who won the Nobel Prize in 2020 for her role in developing CRISPR, we’re just scratching the surface of its potential. Together with graduate student Joy Wang, Doudna laid out a roadmap for the technology’s next decade in an article in Science.

If the 2010s were focused on establishing the CRISPR toolbox and proving its effectiveness, this decade is when the technology reaches its full potential. From CRISPR-based therapies and large-scale screens for disease diagnostics to engineering high-yield crops and nutritious foods, the technology “and its potential impact are still in their early stages,” the authors wrote.

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Researchers have experimentally demonstrated, for the first time, a mechanically flexible silver mesh that is visibly transparent, allows high-quality infrared wireless optical communication and efficiently shields electromagnetic interference in the X band portion of the microwave radio region. Optical communication channels are important to the operation of many devices and are often used for remote sensing and detection.

Electronic devices are now found throughout our homes, on factory floors and in medical facilities. Electromagnetic interference shielding is often used to prevent from these devices from interfering with each other and affecting device performance.

Electromagnetic shielding, which is also used in the military to keep equipment and vehicles hidden from the enemy, can also block the optical communication channels needed for remote sensing, detection or operation of the devices. A shield that can block interference but allow for optical communication channels could help to optimize device performance in a variety of civilian and military settings.

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An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine. The finding suggests that the enzyme may be a potential target for future cancer treatments.

In the new study, published recently in the journal Cancer Research, scientists used a preclinical model of bladder cancer to investigate the role of the enzyme called APOBEC3G in promoting the disease and found that it significantly increased the number of mutations in tumor cells, boosting the genetic diversity of bladder tumors and hastening mortality.

“Our findings suggest that APOBEC3G is a big contributor to bladder cancer evolution and should be considered as a target for future treatment strategies,” said study senior author Dr. Bishoy M. Faltas, assistant professor of medicine in the Division of Hematology and Medical Oncology and of cell and developmental biology at Weill Cornell Medicine, and an oncologist who specializes in urothelial cancers at NewYork-Presbyterian/Weill Cornell Medical Center.

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According to recent research individuals who use statins, a class of drugs that decrease cholesterol levels may have a decreased risk of an intracerebral hemorrhage. Intracerebral hemorrhage is a type of stroke caused by bleeding in the brain. The study was recently published in the journal Neurology.

“While statins have been shown to reduce the risk of stroke from blood clots, there has been conflicting research on whether statin use increases or decreases the risk of a person having a first intracerebral hemorrhage,” said study author David Gaist, MD, Ph.D., of the University of Southern Denmark in Odense and a member of the American Academy of Neurology. “For our study, we looked at the lobe and non-lobe areas of the brain to see if the location was a factor for statin use and the risk of a first intracerebral hemorrhage. We found that those who used a statin had a lower risk of this type of bleeding stroke in both areas of the brain. The risk was even lower with long-term statin use.”

The lobe area of the brain includes most of the cerebrum, including the frontal, parietal, temporal, and occipital lobes. The non-lobe area primarily includes the basal ganglia, thalamus, cerebellum, and brainstem.

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A gene called BPIFB4, discovered in a population of centenarians, could help to reverse the aging of human hearts.

Carriers of healthy mutant genes, including people in so-called “blue zones” of the world, often live to 100 years or more and remain in good health. Cardiovascular complications are also rarer in these individuals. Scientists now believe that a gene may help to keep their hearts young by protecting them against diseases linked to aging.

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You cannot heal as long as you carry a grudge, judgmental thoughts about things that happened in your life that you cannot forgive, or deep feelings of guilt and shame. – Dr. Henning Saupe.

Dr. Henning Saupe, founder of the Arcadia Clinic in Bad Emstal Germany, has spent the last 25 years treating cancer patients with holistic, naturopathic, and integrative therapies.

Dr. Saupe is an expert in insulin potentiation therapy, hyperthermia, botanical and low-dose chemo infusions, PEMF therapy, oxygen and ozone therapies, detox and orthomolecular medicine, meditation, yoga, and psycho-oncology.

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