Biotech/medical – Lifeboat News: The Blog

Dec 10
2013

NASA’s Managerial and Leadership Methodology

This is an excerpt from the conclusion section of, “…NASA’s Managerial and Leadership Methodology, Now Unveiled!..!” by Mr. Andres Agostini, that discusses some management theories and practices. To read the entire piece, just click the link at the end of this illustrated article and presentation:

In addition to being aware and adaptable and resilient before the driving forces reshaping the current present and the as-of-now future, there are some extra management suggestions that I concurrently practice:

1. Given the vast amount of insidious risks, futures, challenges, principles, processes, contents, practices, tools, techniques, benefits and opportunities, there needs to be a full-bodied practical and applicable methodology (methodologies are utilized and implemented to solve complex problems and to facilitate the decision-making and anticipatory process).

The manager must always address issues with a Panoramic View and must also exercise the envisioning of both the Whole and the Granularity of Details, along with the embedded (corresponding) interrelationships and dynamics (that is, [i] interrelationships and dynamics of the subtle, [ii] interrelationships and dynamics of the overt and [iii] interrelationships and dynamics of the covert).

Both dynamic complexity and detail complexity, along with fuzzy logic, must be pervasively considered, as well.

To this end, it is wisely argued, “…You can’t understand the knot without understanding the strands, but in the future, the strands need not remain tied up in the same way as they are today…”

For instance, disparate skills, talents, dexterities and expertise won’t suffice ever. A cohesive and congruent, yet proven methodology (see the one above) must be optimally implemented.

Subsequently, the Chinese proverb indicates, “…Don’t look at the waves but the currents underneath…”

2. One must always be futurewise and technologically fluent. Don’t fight these extreme forces, just use them! One must use counter-intuitiveness (geometrically non-linearly so), insight, hindsight, foresight and far-sight in every day of the present and future (all of this in the most staggeringly exponential mode). To shed some light, I will share two quotes.

The Panchatantra (body of Eastern philosophical knowledge) establishes, “…Knowledge is the true organ of sight, not the eyes.…” And Antonio Machado argues, “… An eye is not an eye because you see it; an eye is an eye because it sees you …”

Managers always need a clear, knowledgeable vision. Did you already connect the dots stemming from the Panchatantra and Machado? Did you already integrate those dots into your big-picture vista?

As side effect, British Prime Minister W. E. Gladstone considered, “…You cannot fight against the future…”

3. In all the Manager does, he / she must observe and apply, at all times, a sine qua non maxim, “…everything is related to everything else…”

4. Always manage as if it were a “project.” Use, at all times, the “…Project Management…” approach.

5. Always use the systems methodology with the applied omniscience perspective.

In this case, David, I mean to assert: The term “Science” equates to about a 90% of “…Exact Sciences…” and to about 10% of “…Social Sciences…” All science must be instituted with the engineering view.

6. Always institute beyond-insurance risk management as you boldly integrate it with your futuring skill / expertise.

7. In my firmest opinion, the following must be complied this way (verbatim): the corporate strategic planning and execution (performing) are a function of a grander application of beyond-insurance risk management. It will never work well the other way around. Transformative and Integrative Risk Management (TAIRM) is the optimal mode to do advanced strategic planning and execution (performing).

TAIRM is not only focused on terminating, mitigating and modulating risks (expenses of treasure and losses of life), but also concentrated on bringing under control fiscally-sound, sustainable organizations and initiatives.

TAIRM underpins sensible business prosperity and sustainable growth and progress.

8. I also believe that we must pragmatically apply the scientific method in all we manage to the best of our capacities.

If we are “…MANAGERS…” in a Knowledge Economy and Knowledge Era (not a knowledge-driven eon because of superficial and hollow caprices of the follies and simpletons), we must do therefore extensive and intensive learning and un-learning for Life if we want to succeed and be sustainable.

As a consequence, Dr. Noel M. Tichy, PhD. argues, “…Today, intellectual assets trump physical assets in nearly every industry…”

Consequently, Alvin Toffler indicates, “…In the world of the future, THE NEW ILLITERATE WILL BE THE PERSON WHO HAS NOT LEARNED TO LEARN…”

We don’t need to be scientists to learn some basic principles of advanced science.

Accordingly, Dr. Carl Sagan, PhD. expressed, “…We live in a society exquisitely dependent on science and technology, in which hardly anyone knows about science and technology…” And Edward Teller stated, “…The science of today is the technology of tomorrow …”

And it is also crucial this quotation by Winston Churchill, “…If we are to bring the broad masses of the people in every land to the table of abundance, IT CAN ONLY BE BY THE TIRELESS IMPROVEMENT OF ALL OF OUR MEANS OF TECHNICAL PRODUCTION…”

I am not a scientist but I tirelessly support responsible scientists and science. I like scientific and technological knowledge and methodologies a great deal.

Chiefly, I am a college autodidact made by his own self and engaged into extreme practical and theoretical world-class learning for Life.

9. In any management undertaking, and given the universal volatility and rampant and uninterrupted rate of change, one must think and operate in a fluid womb-to-tomb mode.

The manager must think and operate holistically (both systematically and systemically) at all times.

The manager must also be: i) Multidimensional, ii) Interdisciplinary, iii) Multifaceted, iv) Cross-functional, and v) Multitasking.

That is, the manager must now be an expert state-of-the-art generalist and erudite. ERGO, THIS IS THE NEWEST SPECIALIST AND SPECIALIZATION.

Managers must never manage elements, components or subsystems separately or disparately (that is, they mustn’t ever manage in series).

Managers must always manage all of the entire system at the time (that is, managing in parallel or simultaneously the totality of the whole at once).

10. In any profession, beginning with management, one must always and cleverly upgrade his / her learning and education until the last exhale.

An African proverb argues, “…Tomorrow belongs to the people who prepare for it…” And Winston Churchill established, “…The empires of the future are the empires of the mind…” And an ancient Chinese Proverb: “…It is not our feet that move us along — it is our minds…”

And Malcolm X observed, “…The future belongs to those who prepare for it today…” And Leonard I. Sweet considered, “…The future is not something we enter. The future is something we create…”

And finally, James Thomson argued, “…Great trials seem to be a necessary preparation for great duties …”

Consequently, Dr. Gary Hamel, PhD. indicates, “…What distinguishes our age from every other is not the world-flattening impact of communications, not the economic ascendance of China and India, not the degradation of our climate, and not the resurgence of ancient religious animosities. RATHER, IT IS A FRANTICALLY ACCELERATING PACE OF CHANGE…”

Please see the full presentation at http://goo.gl/8fdwUP

Dec 10
2013

How nanotechnology can trick the body into accepting fake bones

Megan Cully

Altering the surface of orthopaedic implants has already helped patients – and nanotech can fight infections too

One of medicine’s primary objectives is to trick the body into doing something it doesn’t want to do. We try to convince our immune systems to attack cancer cells (our immune systems don’t normally attack our own bodies), we try to convince neurons to regrow (another unnatural phenomenon), and we try to convince the body to accept foreign bits, such as someone else’s kidney or a fake bone. In order to accomplish this, we try to make parts of our bodies we don’t want, such as cancers, look foreign. We try to make foreign bits that we do want, such as orthopaedic implants, look natural. Nanotechnology, as you might have guessed, can help us do just that.

Dec 9
2013

IBM Creates Nanotechnology to Battle Fungal Infections

Tim Parker, Benzinga Staff Writer

Before scientists create something that has mainstream uses, it often starts as science fiction.

A new technology deep within IBM’s (NYSE: IBM [FREE Stock Trend Analysis]) Singapore research facility isn’t quite ready for the mainstream but when it is, the implications for those who suffer from fungal infections and later, other infections, could have a new ally in their fight but this ally is completely different than current treatments.

If you’re a fan of Star Trek, you’ve seen nanotechnology. These are microscopic machines that get inside machines or in this case, the body, to identify and fix problems.

Scientists have developed a nanomedicine 1,000 times small than a grain of sand that fights fungal infections. Here’s how it works: By creating an electrical charge on each of these tiny particles, they can be programmed to attack only fungal cells while leaving healthy cells alone.

The particles attach themselves to the fungi and rip their cellular membranes apart killing the cell.

This is different than conventional treatments in that it’s a physical attack where the cell is torn apart instead of a drug-like attack where the cell is put to sleep. By killing the cell, there is no opportunity for it to develop a resistance to the nanoparticle. This eliminates the growing problem plaguing doctors: Infections that are increasingly becoming resistant to current therapies.

“It rips the membrane out in a physical attack,” said IBM scientist, James Hedric. “It’s kind of like popping a balloon. We don’t put them to sleep like most drugs do. We kill them. That is why it is so effective. And they can’t adapt to a physical attack. They can adapt to drugs.”

Dec 9
2013

New artificial, bionic hands start to get real feelings

By John Hewitt

Simple tasks, like plucking the stem off a cherry, are still monumental challenges for artificial hands. With a bill of materials perhaps a few hundred components long, it is not surprising that their functionality is low compared with one assembled from trillions of components. A new prosthetic bionic hand, designed and built by researchers at Case Western University is now capable of using measurements from 20 sensor points to control the grip force of its digits. Incredibly, the sensor data is linked directly to the sensory nerves in the patient’s forearm. The control for the grip closure is then extracted myoelectrically from the normal biological return loop to the muscles in the forearm.

Dec 8
2013

Google Glass Makes Its Way Into Operating Rooms

Written By: Cameron Scott

surgery

Hands-free devices like Google Glass can be really transformative when the hands they free are those of a surgeon. And leading hospitals, including Stanford and the University of California at San Francisco, are beginning to use Glass in the operating room.

In October, UCSF’s Pierre Theodore, a cardiothoracic surgeon, became the first doctor in the United States to obtain Institutional Review Board approval to use the device to assist him during surgery. Theodore pre-loads onto Glass the scans of images of the patient taken just before surgery and consults them during the operation.

“To be able to have those X-rays directly in your field without having to leave the operating room or to log on to another system elsewhere, or to turn yourself away from the patient in order to divert your attention, is very helpful in terms of maintaining your attention where it should be, which is on the patient 100 percent of the time,” said Theodore.

Dec 4
2013

How 3D Printers Are Cranking Out Eyes, Bones, and Blood Vessels

Kelsey Campbell-Dollaghan on Gizmodo

At the dawn of rapid prototyping, a common predication was that 3D printing would transform manufacturing, spurring a consumer revolution that would put a printer in every home. That hasn’t quite happened—-and like so many emerging technologies, rapid prototyping has found its foothold in a surprisingly different field: Medicine.

The following studies and projects represent some of the most fascinating examples of “bioprinting,” or using a computer-controlled machine to assemble biological matter using organic inks and super-tough thermoplastics. They range from reconstructing major sections of skull to printing scaffolding upon which stem cells can grow into new bones. More below—and look out for more 3D printing week content over the next few days.

Dec 2
2013

Body piercing controls wheelchair

By James Gallagher

Health and science reporter, BBC News

Body piercings have been used to control wheelchairs and computers in a move scientists believe could transform the way people interact with the world after paralysis.

The movement of a tiny magnet in a tongue piercing is detected by sensors and converted into commands, which can control a range of devices.

The US team said it was harnessing the tongue’s “amazing” deftness.

The development is reported in the journal Science Translational Medicine.

The team at the Georgia Institute of Technology made the unlikely leap from body art to wheelchairs because the tongue is so spectacularly supple.

A large section of the brain is dedicated to controlling the tongue because of its role in speech. It is also unaffected by spinal cord injuries that can render the rest of the body paralysed, tetraplegic, as it has its own hotline to the brain.

“We are tapping in to the inherent capabilities of the tongue, it is such an amazing part of the body,” Dr Maysam Ghovanloo told the BBC.

Dec 2
2013

Hair, bone and soft tissue regrown in mice by enhancing cell metabolism

By Darren Quick

November 11, 2013

Anyone who has left youth behind them knows that bumps and scrapes don’t heal as fast as they used to. But that could change with researchers at the Stem Cell Program at Boston Children’s Hospital finding a way to regrow hair, cartilage, bone, skin and other soft tissues in a mouse by reactivating a dormant gene called Lin28a. The discovery could lead to new treatments that provide adults with the regenerative powers they possessed when very young.

Lin28 is a gene that is abundant in embryonic stem cells and which functions in all organisms. It is thought to regulate the self-renewal of stem cells with the researchers finding that by promoting the production of certain enzymes in mitochondria, it enhances the metabolism of these cellular power plants that found in most of the cells of living organisms. In this way, Lin28 helps generate the energy needed to stimulate the growth of new tissues.

“We already know that accumulated defects in mitochondrial metabolism can lead to aging in many cells and tissues,” says Shyh-Chang Ng. “We are showing the converse – that enhancement of mitochondrial metabolism can boost tissue repair and regeneration, recapturing the remarkable repair capacity of juvenile animals.”

Dec 2
2013

Kurzweil Accelerating Intelligence — Remote virtual surgery via Google Glass and telepresence

A University of Alabama at Birmingham (UAB) surgical team has performed one of the first surgeries using a telepresence augmented reality technology from VIPAAR in conjunction with Google Glass.

The combination of the two technologies could be an important step toward the development of useful, practical telemedicine.

VIPAAR (Virtual Interactive Presence in Augmented Reality) is commercializing a UAB-developed technology that provides real-time, two-way, interactive video conferencing.

Nov 21
2013

Defying Aging: The ELPIs Foundation for Indefinite Lifespans

In is now quite clear that aging is not a simple phenomenon and it will not be overcome by using simple approaches. We need to increase the complexity and sophistication of our efforts in order to be in a better position to develop strategies against it. For this reason, I set up the ELPIS Foundation for Indefinite Lifespans (www.elpisfil.org) which is a scientific research organisation aiming to study aging from a complex evolutionary perspective.

The foundation’s research methodology is based mainly upon the ELPIS hypothesis (www.elpistheory.info). The initials stand for ‘Extreme Lifespans through Perpetual –equalising Interventions’. I developed this hypothesis in 2010 whilst trying to examine the reason behind the presence of aging. It was clear that aging is not an essential component of our evolutionary development, and if we find ways to study why nature has developed it, we may then be able to eradicate it. Currently, the chances of us dying from aging are heavily against us. By developing suitable interventions, we may be able to equalise the odds against us dying (i.e. remove aging as a cause of death).

Our method is different from most existing approaches aiming to eliminate aging. We are mainly interested in the ‘connection-approach’ and not so much in the ‘component-approach’. We believe that it is important to study how the different components of the organism are interconnected and regulated, rather than just repair the individual components. It is the ‘why aging happens’ rather than the ‘how it happens’ that interests us most. In order to make this clear let me mention an analogy with poliomyelitis.

Polio
*How it happens? There is inflammation and necrosis leading to damage of motor neurons and, ultimately, muscle weakness and paralysis
* Why it happens? Because the poliovirus causes it

Aging
* How it happens? There is cellular and molecular damage through oxidation and glycation, as well as damage to mitochondria, DNA etc.
* Why it happens? Because evolution has selected reproduction (and thus aging) as a mechanism for maximising the use of thermodynamical resources, and so ensure the survival of the species.

In this analogy, the obvious cure for polio is to somehow eradicate the poliovirus itself, and not just keep repairing the already damaged motor neurons. And in the case of aging, the best tactic is to somehow change the reason why aging happens, instead of just keep repairing already existing damage.

Attempts such as SENS and similar, aim to repairing existing damage, were as we aim primarily to eliminate the evolutionary reasons behind aging in the first place. This is not to say that we are not at all interested in damage repair. In fact, one of our main projects deals with the repair problem. But, overall we want to explore the evolution of aging and not its secondary effects.

We see aging as a specific and well-defined process. Our aim is unambiguous: we seek to eliminate this particular process. By eliminating aging we will have a life without age-related disease and degeneration, and a lifespan without a predetermined end. We do not seek immortality. In order to be immortal, one has to totally and permanently eliminate all causes of death (not just reduce their incidence). We seek to eliminate aging as one of the causes of death. People will still die from any other cause. In this case, our lifespan would be ‘indefinite’ because the current absolute limit of around 110–120 years will be lifted. There would not be a pre-defined limit; therefore the lifespan would be indefinite. It will not be infinite. This distinction is crucial because it clarifies any ambiguity and vagueness in the terminology. We do not seek eternal youth. We merely concentrate on the process of aging as one of the many other causes of death, the same as other researchers concentrate on the cure for cancer or the cure for HIV infection.

Within ELPIs Foundation we have scientific advisors from a wide range of disciplines, including biomedicine, transhumanism, social sciences, neurosciences, complex systems, and systems biology. Our affiliate researchers are scientists who conduct research in their own facilities and share information and ideas with each other. We are always looking for visionary, ‘out-of the box’ scientific thinkers, those who ‘zoom out’ of reductionist views, and see aging in a wider perspective without being uncritically blinkered by existing dogma.

We ask questions such as: If aging happens because nature withholds resources from the soma and diverts these to the germ-line, how can we reverse this process and divert resources back to the soma in order to maximise biological repair? What is the role of digital hyperconnectivity of billions of humans (the Global Brain) in facilitating such a transition? Where does aging and the elimination of aging fit within an ever-evolving technological tendency of nature? Some ideas we currently explore are:
* Induced Whole-Body Somatic Cell Turnover, for regenerative repair
* Aging and evolutionary changes as applied to human sexual patterns, reproduction, ecosystems, society and the planet
* The role of energy, entropy and thermodynamics in metasystem transitions with regards to human longevity
*Theoretical aspects of Germ-line penetration

May symposium

In May 2014 we will be organising the second symposium on ‘Pathways to Indefinite Lifespans’ in Larnaca, Cyprus. This is a small, very select, highly focused meeting exploring the most cutting-edge research and ideas with regards to the total abolition of aging. We aim to discuss new insights and hypotheses in the fields of biomedical technology, evolutionary anthropology, complex systems, a hyperconnected society, and digital communications technology. The meeting will be accessible live online and will include both local and remote presentations. Those interested in coming need to contact me at: [email protected]. We are also exploring the possibility of offering PhD positions to exceptional candidates, in order to facilitate research in this area.

This article was originally published here: http://hplusmagazine.com/2013/11/05/defying-aging-the-elpis-…lifespans/