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An RNA-dependent RNA polymerase ribozyme that was highly optimized through in vitro evolution for the ability to copy a broad range of template sequences exhibits promiscuity toward other nucleic acids and nucleic acid analogues, including DNA, threose nucleic acid (TNA), and arabinose nucleic acid (ANA). By operating on various RNA templates, the ribozyme catalyzes multiple successive additions of DNA, TNA, or ANA monomers, although with reduced efficiency compared to RNA monomers. The ribozyme can also copy DNA or TNA templates to complementary RNAs, and to a lesser extent it can operate when both the template and product strands are composed of DNA, TNA, or ANA. These results suggest that polymerase ribozymes, which are thought to have replicated RNA genomes during the early history of life, could have transferred RNA-based genetic information to and from DNA, enabling the emergence of DNA genomes prior to the emergence of proteins. In addition, genetic systems based on nucleic acid-like molecules, which have been proposed as precursors or contemporaries of RNA-based life, could have been operated upon by a promiscuous polymerase ribozyme, thus enabling the evolutionary transition between early genetic systems.

Keywords: RNA world; XNA; origins of life; polymerase; reverse transcriptase; ribozyme.

Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown. With the use of polymerase evolution and design, we show that genetic information can be stored in and recovered from six alternative genetic polymers based on simple nucleic acid architectures not found in nature [xeno-nucleic acids (XNAs)]. We also select XNA aptamers, which bind their targets with high affinity and specificity, demonstrating that beyond heredity, specific XNAs have the capacity for Darwinian evolution and folding into defined structures. Thus, heredity and evolution, two hallmarks of life, are not limited to DNA and RNA but are likely to be emergent properties of polymers capable of information storage.

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The world’s first artificial womb facility, EctoLife, will be able to grow 30,000 babies a year. It’s based on over 50 years of groundbreaking scientific research conducted by researchers worldwide which we will cover in this video.

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How does this work for the parent when they have a birth certificate but no baby to show for it, and no record of “disposing” of it?


FORT LAUDERDALE, Fla. (AP) — Safe Haven Baby Boxes and A Safe Haven for Newborns are two charities with similar names and the same goal: providing distressed mothers with a safe place to surrender their unwanted newborns instead of dumping them in trash cans or along roadsides.

But a fight between the two is brewing in the Florida Senate. An existing state law, supported and promoted by the Miami-based A Safe Haven, allows parents to surrender newborns to firefighters and hospital workers without giving their names. A new bill, supported by the Indiana-based Safe Haven Baby Boxes, would give fire stations and hospitals the option to install the group’s ventilated and climate-controlled boxes, where parents could drop off their babies without interacting with fire or hospital employees.

The bill recently passed the Florida House unanimously, but there is a long-shot effort to block it in the Senate, where it might be considered this week. Opponents call the boxes costly, unnecessary and potentially dangerous for the babies, mothers, firefighters and hospital workers. Each side accuses the other of being financially driven.

An illustrated mid-career monograph exploring the 30-year creative journey of the 8-time Academy Award-nominated writer and director

Paul Thomas Anderson has been described as “one of American film’s modern masters” and “the foremost filmmaking talent of his generation.” Anderson’s films have received 25 Academy Award nominations, and he has worked closely with many of the most accomplished actors of our time, including Lesley Ann Manville, Julianne Moore, Daniel Day-Lewis, Joaquin Phoenix, and Philip Seymour Hoffman. In Paul Thomas Anderson: Masterworks, Anderson’s entire career—from Hard Eight (1996), Boogie Nights (1997), Magnolia (1999), Punch Drunk Love (2002), There Will Be Blood (2007), The Master (2012), Inherent Vice (2014), and Phantom Thread (2017) to his music videos for Radiohead to his early short films—is examined in illustrated detail for the first time.

Anderson’s influences, his style, and the recurring themes of alienation, reinvention, ambition, and destiny that course through his movies are analyzed and supplemented by firsthand interviews with Anderson’s closest collaborators—including producer JoAnne Sellar, actor Vicky Krieps, and composer Jonny Greenwood—and illuminated by film stills, archival photos, original illustrations, and an appropriately psychedelic design aesthetic. Masterworks is a tribute to the dreamers, drifters, and evil dentists who populate his world.

Homologous pairing (HP), i.e., the pairing of similar or identical double-stranded DNA, is an insufficiently understood fundamental biological process. HP is now understood to also occur without protein mediation, but crucial mechanistic details remain poorly established. Unfortunately, systematic studies of sequence dependence are not practical due to the enormous number of nucleotide permutations and multiple possible conformations involved in existing biophysical strategies even when using as few as 150 basepairs. Here, we show that HP can occur in DNA as short as 18 basepairs in a colloidal microparticle-based system. Exemplary systematic studies include resolving opposing reports of the impact of % AT composition, validating the impact of nucleotide order and triplet framework and revealing isotropic bendability to be crucial for HP. These studies are enabled by statistical analysis of crystal size and fraction within coexisting fluid-crystal phases of double-stranded DNA-grafted colloidal microspheres, where crystallization is predicated by HP.

We may build incredible AI. But can we contain our cruelty? Oxford professor Nick Bostrom explains.

Up next, Is AI a species-level threat to humanity? With Elon Musk, Michio Kaku, Steven Pinker & more ► https://youtu.be/91TRVubKcEM

Nick Bostrom, a professor at Oxford University and director of the Future of Humanity Institute, discusses the development of machine superintelligence and its potential impact on humanity. Bostrom believes that in this century, we will create the first general intelligence that will be smarter than humans. He sees this as the most important thing humanity will ever do, but it also comes with an enormous responsibility.

Bostrom notes that there are existential risks associated with the transition to the machine intelligence era, such as the possibility of an underlying superintelligence that overrides human civilization with its own value structures. In addition, there is the question of how to ensure that conscious digital minds are treated well. However, if we succeed in ensuring the well-being of artificial intelligence, we could have vastly better tools for dealing with everything from diseases to poverty.

Ultimately, Bostrom believes that the development of machine superintelligence is crucial for a truly great future.

0:00 Smarter than humans.

The makers noticed that the processing time with GPT-4 was much longer than GPT-3 and made Ameca appear less responsive with her facial expressions.

In December 2021, we brought to you the ‘world’s most advanced humanoid robot’. Ameca, born of a UK-based company Engineered Arts, displayed a multitude of human-like expressions in August 2022. Now, the developers behind Ameca have released a new video in which the bot can be seen exhibiting its polyglot-like qualities — speaking several languages including Japanese, German, Chinese, French, British, and American English.


Engineered Arts.

This Ameca demonstration used GPT-3 for conversation and translation, DeepL for language detection, and Amazon Polly Neural voices, according to the YouTube description. The team is currently working on a demo using Eleven labs voice cloning which adds complexity, thanks to the additional “phoneme and Visme generation” for lip sync. They will be integrated into the company’s Tritium software platform. And a beta public version will be released in the coming months.