A new method that increases the signal from CRISPR-based diagnostic tests, removing the need for amplification of DNA or RNA in a sample, could be used to quickly diagnose heart attacks and differentiate between cancer types.
A discovery made by researchers at the University of California, Irvine on how a certain protein is activated in tumor cells may lead to more effective treatments for some of the most deadly types of cancer. The finding, which was led by scientists at the School of Biological Sciences, may potentially result in treatment options for the especially dangerous melanoma and pancreatic adenocarcinoma, as well as the most common type of childhood brain cancer and adult skin cancer. The study was published in the journal Life Science Alliance.
The GLI1 protein, which is essential for cell development but has also been linked to a number of cancers, was the subject of the finding. The Hedgehog signaling pathway, also known as HH, usually activates GLI1. However, scientists have known for almost a decade that crosstalk, or interaction, between HH and the mitogen-activated protein kinase pathway, has a role in cancer.
“In some cases, proteins in one pathway can turn on proteins in another,” said lead author A. Jane Bardwell, a project scientist in UCI’s Department of Developmental and Cell Biology. “It’s a complex system. We wanted to understand the molecular mechanism that leads to GLI1 being activated by proteins in the MAPK pathway.”
Researchers from the University of Pennsylvania demonstrated in a proof-of-concept study that a hands-free device could successfully automate the treatment and removal of dental plaque and bacteria that cause tooth decay.
In the future, a shape-shifting robotic microswarm may serve as a toothbrush, rinse, and dental floss all in one. The technology, created by a multidisciplinary team at the University of Pennsylvania, has the potential to provide a brand-new, automated method for carrying out the repetitive but important daily duties of brushing and flossing. For people who lack the manual dexterity to efficiently clean their teeth alone, this system could be extremely helpful.
These microrobots are composed of iron oxide nanoparticles with catalytic and magnetic properties. Researchers were able to control their movement and configuration using a magnetic field to either produce bristle-like structures that remove dental plaque from the wide surfaces of teeth or elongated threads that can slide between teeth like a piece of floss. In both situations, the nanoparticles are driven by a catalytic reaction to release antimicrobials that eliminate harmful oral bacteria on site.
Dr. Asha M. George, DrPH (https://biodefensecommission.org/teams/asha-m-george-drph/) is Executive Director, Bipartisan Commission on Biodefense, which was established in 2014 to assess gaps in and provide recommendations to improve U.S. biodefense. The Panel determines where the United States is falling short of addressing biological attacks and emerging and reemerging infectious diseases.
Dr. George is a public health security professional whose research and programmatic emphasis has been practical, academic, and political. She served in the U.S. House of Representatives as a senior professional staffer and subcommittee staff director at the House Committee on Homeland Security in the 110th and 111th Congress. She has worked for a variety of organizations, including government contractors, foundations, and non-profits. As a contractor, she supported and worked with all Federal Departments, especially the Department of Homeland Security and the Department of Health and Human Services.
Summary: Dampening retromer activity slows down the trafficking of tau in neurodegenerative disorders, a new study reports.
Source: EPFL
Neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease are associated with atypical proteins that form tangles in the brain, killing neurons. Neurobiologists at EPFL have now identified some key mechanisms underlying the formation of these tangles.
Summary: Researchers have identified human-specific cell types in the prefrontal cortex. These unique cells may explain why humans are more susceptible to neuropsychiatric diseases than other primate species.
Source: Yale.
What makes the human brain distinct from that of all other animals—including even our closest primate relatives?
According to research conducted by the University of Pennsylvania, the enzyme DOT1L, a stem cell self-renewal factor, is necessary for mice to continue producing sperm throughout adulthood.
Men may continue to generate sperm throughout their adult life, in contrast to women who are born with all the eggs they will ever have. To do so, they must constantly renew the spermatogonial stem cells that give birth to sperm.
According to research by Jeremy Wang of the University of Pennsylvania School of Veterinary Medicine and colleagues, this stem cell renewal is dependent on a recently identified stem cell self-renewal factor known as DOT1L. The scientists demonstrated that animals lacking DOT1L are unable to retain spermatogonial stem cells, which affects their ability to constantly make sperm.
Due to a rare genetic mutation, Aliria Rosa Piedrahita de Villegas should have had Alzheimer’s.
Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.
Hey it’s Han from WrySci-HX talking about how the anti diabetic drug Empagliflozin, brand name Jardiance, has reversed signs of vascular aging in mice! Is this why we’re seeing its benefits in humans? More below ↓↓↓
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