According to a recent study by researchers at Weill Cornell Medicine, a protein that prepares DNA
DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).
Adding evidence to the importance of early development, a new study links neutral maternal behavior toward infants with an epigenetic change in children related to stress response.
Epigenetics are molecular processes independent of DNA that influence gene behavior. In this study, researchers found that neutral or awkward behavior of mothers with their babies at 12 months correlated with an epigenetic change called methylation, or the addition of methane and carbon molecules, on a gene called NR3C1 when the children were 7 years old. This gene has been associated with regulating the body’s response to stress.
“There is evidence of a relationship between the quality of maternal-infant interaction and methylation of this gene though these are small effects in response to a relatively small variation in interaction,” said Elizabeth Holdsworth, a Washington State University biological anthropologist and lead author of the study published in the American Journal of Human Biology.
Poor sleep could lead to between two and seven years worth of heightened heart disease risk and even premature death, according to a new study led by researchers at the University of Sydney in collaboration with Southern Denmark University.
The study analyzed data from more than 300,000 middle-aged adults from the UK Biobank and found that different disturbances to sleep are associated with different durations of compromised cardiovascular health later in life compared to healthy sleepers.
In particular, men with clinical sleep-related breathing disorders lost nearly seven years of cardiovascular disease-free life compared to those without these conditions, and women lost over seven years. Importantly, even general poor sleep, such as insufficient sleep, insomnia complaints, snoring, going to bed late, and daytime sleepiness is associated with a loss of around two years of normal heart health in men and women.
A team of researchers from Michigan State University’s College of Veterinary Medicine has made a discovery that may have implications for therapeutic gene editing strategies, cancer diagnostics and therapies and other advancements in biotechnology.
Kathy Meek, a professor in the College of Veterinary Medicine, and collaborators at Cambridge University and the National Institutes of Health have uncovered a previously unknown aspect of how DNA double-stranded breaks are repaired.
A large protein kinase called DNA-PK starts the DNA repair process; in their new report, two distinct DNA-PK protein complexes are characterized, each of which has a specific role in DNA repair that cannot be assumed by the other.
Summary: Using AI, researchers identified Probucol, an existing anti-cholesterol drug that promotes the disposal of mitochondria, as a potential new therapy for the treatment of Parkinson’s disease.
Source: PLOS
The words that researchers use to describe their results can be harnessed to discover potential new treatments for Parkinson’s disease, according to a new study publishing March 2nd in the open access journal PLoS Biology by Angus McQuibban of the University of Toronto, Canada, and colleagues.
Dr. Axel Montagne is a chancellor’s fellow and group leader at the UK Dementia Research Institute at the University of Edinburgh Centre for Clinical Brain Sciences. His group aims to understand how, when, and where critical components of the blood-brain barrier become dysfunctional preceding dementia and in the earliest stages of age-related cognitive decline. With this knowledge, they hope to develop precise treatments targeting brain vasculature to protect brain function.
More importantly his work, and that of his colleagues, provide a critical lens through which to view the contributions of vascular dysfunction (or, conversely, vascular health – if we choose to preserve it) as a critical common thread in dementia and neurodegeneration.
There is this picture—you may have seen it. It is black and white and has two silhouettes facing one another. Or maybe you see the black vase with a white background. But now, you likely see both.
It is an example of a visual illusion that reminds us to consider what we did not see at first glance, what we may not be able to see, or what our experience has taught us to know—there is always more to the picture or maybe even a different image to consider altogether. Researchers are finding the process in our brain that allows us to see these visual distinctions may not be happening the same way in the brains of children with autism spectrum disorder. They may be seeing these illusions differently.
“How our brain puts together pieces of an object or visual scene is important in helping us interact with our environments,” said Emily Knight, MD, Ph.D., assistant professor of Neuroscience and Pediatrics at the University of Rochester Medical Center, and first author on a study out today in the Journal of Neuroscience. “When we view an object or picture, our brains use processes that consider our experience and contextual information to help anticipate sensory inputs, address ambiguity, and fill in the missing information.”
From physics to mind: the journey of cognition seen through the lens of embryonic development // Prof. Michael Levin (Tufts University)
Life Perceives is a symposium bringing together scientists and artists for an open exploration of how “perception” can be understood as a phenomenon that does not only belong to humans, or even the so-called “higher organisms”, but exists across the entire spectrum of life in a myriad of forms.
The symposium invites leading practitioners from the arts and sciences to present unique insights through short talks, open discussions, and artistic interventions that bring us slightly closer to the life worlds of plants and fungi, microbial communities and immune systems, cuttlefish and crows.
What do we mean when we talk about perception in other species? Do other organisms have an experience of the world? Or does our human-centred perspective make understanding other forms of life on their own terms an impossible dream? Whatever your answers to these questions may be, we hope to unsettle them, and leave you more curious than when you arrived.
The symposium will be accompanied by a photography exhibition by award-winning photographer Irina Petrova Adamatzky, and an installation, The Sentinel Self, by Danish artist Sissel Marie Tonn in the Jane Attenborough Studio.
Men who regularly lift heavy objects at work have almost 50 percent higher sperm concentration and count.
As infertility is becoming a common problem of late, and medical professionals are scrambling to find solutions to nullify this rising trend. Researchers have found a link between male fertility and occupational factors, such as physical demands and work schedules.
The Harvard Medical School (HMS) and Brigham and Women’s Hospital collaborative effort found that men who “regularly lift heavy objects at work have higher sperm counts than men whose work is less physically demanding,” a press release said.
Give at least 11 minutes to your body, and it could do wonders for you.
Cambridge University researchers propose that people can reduce their risk of early death from heart disease, cancer, and various other health problems — just by doing 11 minutes of brisk walking or any other moderate-intensity physical activity daily.
This is half the effort that National Health Service (NHS) recommended in the past to lead a long and healthy life. According to NHS, a person between 19 to 64 years of age should spend at least 150 minutes a week (about 21 hours a day) doing moderate-intensity exercise.
