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Category: biotech/medical – Page 874

A company has donated 350 of Smit’s, the biomechanical engineer behind the design, 3D-printed prosthetic hands to war victims in Ukraine.

Delft University of Technology (TU Delft) researchers designed laser-cutting 3D-printed prosthetic hands for Ukranian war victims. Thanks to laser-cutting technology, war victims get their prosthetic limbs more easily. These prosthetic hands are in use in India, and Indian company Vispala donated 350 of Smit’s 3D-printed prosthetic hands to war victims in Ukraine, according to the TU Delft.

Designed by biomedical engineer Gerwin Smit, the so-called “Hundred Dollar Hand” is very cheap to produce. Smit’s artificial hand offers a sturdy and trustworthy option because 80 percent of persons who require a prosthetic hand reside in nations with few resources. Delft-produced 350 prosthetic hands donated to Ukrainian War wictims.

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The researchers looked at randomized, controlled intervention trials evaluating 27 different types of antioxidant supplements. They found strong evidence that several offered cardiovascular benefits. These included omega-3 fatty acid, which decreased mortality from cardiovascular disease; folic acid, which lowered stroke risk; and coenzyme Q10, an antioxidant sometimes marketed as CoQ10, which decreased all-cause mortality. Omega-6 fatty acid, L-citrulline, L-arginine, quercetin, melatonin, curcumin, Vitamin D, zinc, magnesium, alpha-lipoic acid (ALA), catechin, flavanol, and genistein also showed evidence of reducing cardiovascular risk.

Not all supplements were beneficial. Vitamin C, Vitamin D, Vitamin E, and selenium showed no effect on long-term cardiovascular disease outcomes or type-2 diabetes risk. And beta carotene supplements increased all-cause mortality.

Healthy dietary patterns are rich in micronutrients, but their influence on cardiovascular disease (CVD) risks has not been systematically quantified.

The goal of this study was to provide a comprehensive and most up-to-date evidence-based map that systematically quantifies the impact of micronutrients on CVD outcomes.

Continue reading “Micronutrient Supplementation to Reduce Cardiovascular Risk” | >

Aubrey De Grey discusses the progress and potential of therapies related to his ideas on anti-aging medicine, including the four therapies that will be tested in a mouse rejuvenation trial. He also shares his thoughts on partnering with organizations and individuals in the field, integrating AI into his work, and the importance of structure in maximizing impact. Aubrey de Grey discusses the potential for Yamanaka factors to be used in organ rejuvenation, and the role of transcription factors in creating induced pluripotent stem cells. He also provides advice for those interested in getting involved in the field and shares his views on time management and productivity. Aubrey De Grey discusses the potential for reversing the pathology of aging to address mechanical issues and mentions promising research being conducted by MAIA Biotechnology on cancerous cells that express telomerase. He also expresses his optimism about the possibility of reaching “longevity escape velocity” within the next 15 years.

Youtube:
Aubrey De Grey links.
https://twitter.com/aubreydegrey?ref_src=twsrc%5Egoogle%7Ctw…r%5Eauthor.
https://www.levf.org/
https://www.linkedin.com/in/aubrey-de-grey-24260b/

PODCAST INFO:
The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson-is a lifelong autodidact, serial problem solver, and founder of startups.
LINKS
Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q
Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA
Linkedin: https://www.linkedin.com/in/lowell-thompson-2227b074
Twitter: https://twitter.com/LWThompson5
Website: https://www.learningwithlowell.com/
Podcast email: [email protected].
Timestamps.
00:00 Start.
01:00 Mark Hamaleinen write in question: Why we still don’t have any therapies based on his ideas published 20 years ago in his breakout paper.
04:30 update on escape velocity. 50% in 15 years.
08:30 Experiments on mice.
12:00 Yamanaka factor thoughts, current research on mice continued.
14:30 Lev foundation research expanded and explained.
16:30 Lev foundation thesis compared to others.
21:00 Hardships being at the tip of the innovation field of longevity.
23:45 Open source, non profits, lev foundation.
26:00 Ideas from previous organizations (ie. SENS) applied in LEV
27:15 Ichor therapeutics, and partnership process of LEV
29:30 Next generation mentorship.
30:30 Summer internship program.
32:45 Bullish on longevity.
33:30 AI role in longevity.
35:55 Anything fundamental making longevity therapies only for the rich.
38:30 Longevity surgery therapies.
39:30 Advice for people.
40:30 Bottlenecks of longevity.
42:00 Books!
43:05 Staying on cutting edge/ learning.
44:15 Current curiosity and fascination.
46:45 What happiness means to him and how he optimizes for it.
48:30 how he stays healthy over the years, longevity practices he uses.
51:45 How much money does he and the space need.
52:55 Anything stopping him from getting Jeff Bezos and other high network people to invest or donate.
51:55 Thoughts on altos labs & calico labs.
56:35 up and coming people that inspire him (crypto people, michael levin)
59:00 Finding up and coming people to work with and for (advice)
60:30 Things people get wrong and what people ask him about longevity.
1:01:35 Aubrey newsletter and updates (news suggestions)
1:03:30 Question he wonders about that doesn’t have answer to.
1:04:15 How he maximizes his day and stays productive.
1:05:15 Thoughts on MAIA Biotechnology, telomerase, short vs long.
1:09:30 Final thoughts on lev foundation.

#longevity #aubreydegrey #LEVF

Continue reading “Aubrey De Grey: longevity escape velocity, longevity, mouse rejuvenation, Altos Labs, Yamanaka factor” | >

The reason your three-pound brain doesn’t feel heavy is because it floats in a reservoir of cerebrospinal fluid (CSF), which flows in and around your brain and spinal cord. This liquid barrier between your brain and skull protects it from a hit to your head and bathes your brain in nutrients.

But the CSF has another critical, if less known, function: it also provides to the brain. Yet, this function hasn’t been well studied.

A Northwestern Medicine study of CSF has discovered its role in , such as Alzheimer’s disease. This discovery provides a new clue to the process of neurodegeneration, said study lead author David Gate, assistant professor of neurology at Northwestern University Feinberg School of Medicine.

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A new study by Burke Neurological Institute (BNI), Weill Cornell Medicine, finds that activation of MAP2K signaling by genetic engineering or non-invasive repetitive transcranial magnetic stimulation (rTMS) promotes corticospinal tract (CST) axon sprouting and functional regeneration after spinal cord injury (SCI) in mice.

RTMS is a noninvasive technique that evokes an electrical field in via electromagnetic induction. While an increasing body of evidence suggests that rTMS applied over motor cortex may be beneficial for functional recovery in SCI patients, the molecular and cellular mechanisms that underlie rTMS’ beneficial effects remains unclear.

A new study published in Science Translation Medicine showed that high-frequency rTMS (HF-rTMS) activated MAP2K signaling and enhanced axonal regeneration and functional recovery, suggesting that rTMS might be a valuable treatment option for SCI individuals.

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Exercise and physical activity reduce the risk of cardiovascular disease (CVD). It has been observed that an active individual is at a 30% to 40% lower risk of CVD. However, previous cross-sectional studies have failed to determine whether exercise has a significant impact on expediting coronary atherosclerosis and plaque morphology. A recent Circulation journal paper has focused on investigating the relationship between exercise volume and intensity and the progression of coronary atherosclerosis in middle-aged and older male athletes.

Study: Exercise Volume Versus Intensity and the Progression of Coronary Atherosclerosis in Middle-Aged and Older Athletes: Findings From the MARC-2 Study. Image Credit: sciencepics / Shutterstock.

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People age at different rates due to a variety of intrinsic and extrinsic factors, which can affect their biological age and their risk of developing diseases or experiencing early death. This is why two individuals who are both 50 years old may not have the same level of biological aging, despite having lived for the same number of years.

Lifestyle choices, such as diet and smoking, and illness all contribute to accelerating biological age beyond one’s chronological age. Researchers have discovered that grip strength, a measure of overall muscle strength, is linked to biological age in this way. In particular, the study, which was published in the Journal of Cachexia, Sarcopenia, and Muscle, found that people with weaker grip strength had older biological ages.

Researchers at Michigan Medicine modeled the relationship between biological age and grip strength of 1,274 middle-aged and older adults using three “age acceleration clocks” based on DNA.

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This past year, global attention has been focused on geo-strategic issues, such as the devastating war in Ukraine, which has dislocated many and caused immense suffering. Attention has also been focused on the recovery from the COVID pandemic, which was the overriding concern over the past three years. And finally, the economic destruction wrought by rapidly ramped interest rates which have targeted all sectors of the economy, particularly technology. But despite all this negativity, the business of building the future continues. There has been progress across major axes of computing, from visualization to AI and new types of processors (quantum).

With immense progress in technology, what might we look forward to in 2023?

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Though it is a cornerstone of virtually every process that occurs in living organisms, the proper folding and transport of biological proteins is a notoriously difficult and time-consuming process to experimentally study.

In a new paper published in eLife, researchers in the School of Biological Sciences and the School of Computer Science have shown that AF2Complex may be able to lend a hand.

Building on the models of DeepMind’s AlphaFold 2, a machine learning tool able to predict the detailed three-dimensional structures of individual proteins, AF2Complex—short for AlphaFold 2 Complex—is a deep learning tool designed to predict the physical interactions of multiple proteins. With these predictions, AF2Complex is able to calculate which proteins are likely to interact with each other to form functional complexes in unprecedented detail.

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