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Changing the epigenetic marks on chromosomes results in altered gene expression in offspring and in grandoffspring, demonstrating ‘transgenerational epigenetic inheritance.’

Without changing the genetic code in the DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Although just cute little creatures at first glance, the microscopic geckos and octopuses fabricated by 3D laser printing in the molecular engineering labs at Heidelberg University could open up new opportunities in fields such as microrobotics or biomedicine.

The printed microstructures are made from novel materials —known as smart polymers—whose size and mechanical properties can be tuned on demand and with high precision. These “life-like” 3D microstructures were developed in the framework of the “3D Matter Made to Order” (3DMM2O) Cluster of Excellence, a collaboration between Ruperto Carola and the Karlsruhe Institute of Technology (KIT).

“Manufacturing programmable materials whose mechanical properties can be adapted on demand is highly desired for many applications,” states Junior Professor Dr. Eva Blasco, group leader at the Institute of Organic Chemistry and the Institute for Molecular Systems Engineering and Advanced Materials of Heidelberg University.

Understanding how metastasis works.

In the universal fight against cancer, metastasis is one of the most unpleasant factors that could make matters even worse; and there is still much to comprehend in the spread process. Cambridge scientists might have unveiled a breakthrough in understanding how metastasis works.

The research has been published in the journal Nature Genetics.

Continue reading “A breakthrough in metastasis could lead to better cancer treatments” »

The researchers brilliantly demonstrated, for the very first time, how to chemically transform an abundant, plant-based starting material into EBC-46.

In what can be called a major scientific breakthrough, Stanford researchers have discovered a “rapid and sustainable” way to synthetically produce a promising cancer-fighting compound, designated EBC-46, right in the lab, according to a press release published by the institution.

This was “something many people had considered impossible,” as the compound’s only currently known source is a single plant species that grows solely in a small rainforest region of Northeastern Australia.

Building A Clinically Credible Platform For Longevity Medicine — Prof. Dr. Andrea Maier MD, PhD, National University of Singapore, Centre for Healthy Longevity.

Professor Dr. Andrea B. Maier, MD, Ph.D., is the Oon Chiew Seng Professor in Medicine, Healthy Ageing and Dementia Research, and Co-Director of the Centre for Healthy Longevity, at the National University Of Singapore (https://discovery.nus.edu.sg/19564-andrea-britta-maier).

Continue reading “Prof. Dr. Andrea B. Maier, MD, PhD — Building A Clinically Credible Platform For Longevity Medicine” »

A new study from the Garvan Institute of Medical Research shows how rises in core body temperature may trigger the inflammatory flares in people with a rare genetic autoinflammatory disease.

The recessive disorder, called mevalonate kinase deficiency (MKD), is caused by mutations in the gene for mevalonate kinase, an essential enzyme present in all cells in the body. Lack of this enzyme leads to a build-up of abnormal proteins, which causes cells of the immune system to malfunction and trigger inflammation.

Continue reading “Higher body temperature alters key protein in autoinflammatory disorder” »

Researchers recently demonstrated artificial wombs keeping embryonic-stem-cell-derived mice alive for almost half their gestational period.

Oxytocin, sometimes called the “love hormone,” may help heal broken hearts — literally. In a new study of zebrafish and human cells, scientists found that the brain-made hormone may help heart tissue regenerate after injury and, in theory, could someday be used in the treatment of heart attacks, according to the researchers.

Because the new study was conducted in fish tanks and lab dishes, however, this theoretical treatment is still far from realization.

Scientists have discovered a fluorescent protein that flouts trade-off relationships.

Scientific research institute RIKEN produced bright and photostable green fluorescent protein from Japanese jellyfish. Published in Nature Biotechnology.

Proteins that emit green light when illuminated are effective instruments for capturing images of intricate cell architecture. Such fluorescent proteins can be attached to target structures of interest, which light up when exposed to blue light.

Continue reading “Japanese scientists produce bright and photostable green fluorescent protein from jellyfish” »