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Category: biotech/medical – Page 79

Neoadjuvant vs Adjuvant Immunotherapy in Stage III Colon Cancer

Adjuvant immunotherapy plus chemotherapy has yet to square off against neoadjuvant immunotherapy in a head-to-head trial. Even if that trial doesn’t happen, post hoc analyses of ATOMIC and the neoadjuvant NICHE-2 studies may clarify whether a one-size-fits-all approach is appropriate and help determine which patients benefit more from one approach over the other, according to Christopher Lieu, MD, an investigator in the ATOMIC study.

The ATOMIC study showed that adding adjuvant immunotherapy to standard-of-care chemotherapy following resection reduced the risk for disease recurrence or death by 50% compared with chemotherapy alone in the 355 patients with stage III colon cancer with mismatch repair deficiency (dMMR), who received adjuvant atezolizumab along with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy, providing those in the pro-adjuvant camp with important data. In addition, 3-year disease-free survival (DFS) was 86.4% with the combination compared with 76.6% with chemotherapy alone. The results of this trial were presented at the American Society of Clinical Oncology (ASCO) 2025.

Experts debate which patients with stage III dMMR colon cancer will benefit from the two treatment approaches.

2025 UP.Partners Moving World Report

Emerging technologies, such as autonomous vehicles, drones, and humanoid robotics, are rapidly transforming industries and revolutionizing transportation, logistics, and other sectors, driven by decreasing costs, economic incentives, and significant investments.

Questions to inspire discussion.

Emerging Technologies 🚁 Q: How are drones revolutionizing delivery services? A: Drones are delivering millions of goods with insane energy efficiency, cost-effectiveness, and convenience, exemplified by Google’s Wing program partnering with Walmart and DoorDash, and Zipline saving half a million lives delivering medicine worldwide. 🤖 Q: What roles can humanoid robots fill in the workforce?

Scientists Discovered a Way to Reverse Time—and Possibly Erase Mistakes

In the subatomic universe of quantum physics, you can achieve things considered impossible in our flesh-and-blood physical world. Things like superposition, entanglement, and even teleportation all seem possible when things go quantum. Now, scientists from the Austrian Academy of Sciences (ÖAW) and University of Vienna are adding a kind of time travel to the list.

In a series of papers published on preprint servers and in various online journals (including Optica, arXiv, and Quantum), researchers including ÖAW’s Miguel Navascués and University of Vienna’s Philip Walther explain the possibility of speeding up, slowing down, and even reversing the flow of time within a quantum system.

Newly found mechanism can supercharge the immune system against cancers

New research has uncovered a novel mechanism that may help explain why some people with cancer respond remarkably well to immunotherapy while others don’t.

Researchers from the Garvan Institute of Medical Research and UNSW Sydney have uncovered that less active versions of a gene called NOD2, in combination with radiotherapy or immunotherapy, may help supercharge the immune system’s ability to attack cancer.

The findings, published in the journal Proceedings of the National Academy of Sciences, could pave the way for more personalized and effective immunotherapy treatments against a range of cancers.

Exposure to nanoplastics could induce spread of Alzheimer’s disease from the brain to other organs

A new preclinical study has found exposure to nanoplastics may contribute to the rapid progression of Alzheimer’s disease and subsequent spread from the brain to other key organs such as the liver, heart and gut.

The research, “Cerebral to Systemic Representations of Alzheimer’s Pathogenesis Stimulated by Polystyrene Nanoplastics,” is published in the journal Environment & Health.

The study, co-led by Monash University and South China University of Technology, investigated how environmental-level polystyrene exposure influences the progression of Alzheimer’s disease from the brain to other parts of the body. Studies in mice revealed that nanoplastic-induced neurological damage is not confined within the brain, but expands systemically through the gut–liver–brain axis.

Detecting early-stage tumors with a blood sample

Current methods for cancer diagnosis are based on identifying biomarkers — molecules that reveal a particular state or process in the body – produced by the tumor or associated proteins. Not surprisingly, these markers are more abundant once the tumor has already developed significantly. And the more advanced the tumor, the more difficult it is to find effective treatment options.

Now, a research team has developed a test that can detect early-stage solid tumors with just a blood sample. In addition, the test also provides information relevant to the choice of treatment.

To achieve this early detection, the team focused the test not on the markers produced by the tumor, but on the body’s defensive reaction to the cancer. Since the 19th century it has been known that the emergence of cancer cells causes changes in the immune system, and it was also known that these changes are more intense in cancer’s earliest stages. But they had never been used for diagnosis. The new study focuses on them, specifically on the changes in blood proteins derived from cancer’s disruption of the immune system.

But this approach posed a problem to the team: human blood contains more than 5,000 proteins, which makes it extremely difficult to analyze. So they used bioinformatics analysis and narrowed the scope of the study to five amino acids: lysine, tryptophan, tyrosine, cysteine and cysteine not bound to disulphide bonds.

They then subjected the sample to reactions that emit fluorescence when light is applied to them — fluorogenic reactions — and revealed the exact concentration of each of these amino acids in the plasma. Using the artificial intelligence tool machine learning, they identified patterns in these concentrations that could be translated into diagnostic signals.

As they explain in the published article, they applied this technique to samples from 170 patients and were able to identify 78% of cancers with a 0% false positive rate.

Human CLOCK gene enhances brain connectivity and mental flexibility in mice, study finds

Clock genes are a set of genes known to contribute to the regulation of the human body’s internal 24-hour cycle, also known as the circadian rhythm. One of these genes is the so-called CLOCK gene, a protein that regulates the activity of other genes, contributing to recurrent patterns of sleep and wakefulness.

Past findings suggest that this gene is also expressed in the neocortex, a brain region that supports important cognitive abilities, including reasoning, decision-making and the processing of language. However, the gene’s possible contribution to these specific brain functions remains poorly understood.

Researchers at UT Southwestern Medical Center recently carried out a study on genetically modified mice aimed at better understanding how the expression of the CLOCK gene in the human neocortex influences cognitive functions. Their findings, published in Nature Neuroscience, suggest that the gene plays a role in the formation of connections between neurons, which in turn influence mental and behavioral flexibility.

When does the body really start aging? The answer may surprise you

When does aging really shift into overdrive? A new study suggests it may be sooner than you think.

Scientists at the Chinese Academy of Sciences studied proteins in tissue taken from about 70 people ages 14 to 68, according to the study published July 25 in the journal Cell.

These proteins give scientists a window of when the aging process may begin on a cellular level, said Dr. Thomas Blackwell, associate dean for graduate medical education and professor of medicine at the University of Texas Medical Branch.

New research unveils vast influence of B vitamins on health and disease

Eight essential nutrients make up the suite of B vitamins also known as the B complex. Researchers from Tufts University and elsewhere have revealed that these B vitamins influence a vast spectrum of human health and disease, including cognitive function, cardiovascular health, gastric bypass recovery, neural tube defects, and even cancer.

“It’s hard to study the B vitamins in isolation,” says gastroenterologist Joel Mason, senior scientist at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) and professor at the Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy and Tufts University School of Medicine. “Four of these B-vitamins cooperate as co-factors in many critical activities in cells in what we call ‘one carbon metabolism’.”

One carbon metabolism is a series of pathways that allow for the transfer of single-carbon units to cells for essential processes such as DNA synthesis, amino acid metabolism, and more. It’s their role in all these crucial biological functions that make the B vitamins so important-and so challenging to tease out how they contribute positively and, perhaps negatively, to human health.

MIT engineers uncover a surprising reason why tissues are flexible or rigid

Water makes up around 60 percent of the human body. More than half of this water sloshes around inside the cells that make up organs and tissues. Much of the remaining water flows in the nooks and crannies between cells, much like seawater between grains of sand.

Now, MIT engineers have found that this “intercellular” fluid plays a major role in how tissues respond when squeezed, pressed, or physically deformed. Their findings could help scientists understand how cells, tissues, and organs physically adapt to conditions such as aging, cancer, diabetes, and certain neuromuscular diseases.

In a paper appearing today in Nature Physics, the researchers show that when a tissue is pressed or squeezed, it is more compliant and relaxes more quickly when the fluid between its cells flows easily. When the cells are packed together and there is less room for intercellular flow, the tissue as a whole is stiffer and resists being pressed or squeezed.

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