A Phase 1 trial shows a personalized DNA vaccine (GNOS-PV01) is safe and doubles survival rates for aggressive glioblastoma.
Category: biotech/medical – Page 79
Engineered brain ‘bypass’ that rewires specific circuits could boost resilience to stress
Broken or disrupted circuits in the brain contribute to many neurological disorders. A new custom-built biological “wire” developed at Duke University School of Medicine points the way toward a new treatment approach—bypassing broken brain connections, rather than relying on long-term medication or external stimulation.
Researchers led by Kafui Dzirasa, MD, Ph.D., have developed a technology called LinCx that allows scientists to create new electrical connections between carefully chosen neurons. Unlike existing tools that often influence many cells at once, this approach enables selective, long-lasting changes in how defined brain circuits function. The study is published in Nature.
“By introducing a way to plug in new electrical connections with cellular-level precision, our study marks a major step forward in the ability to edit brain circuitry and understand how neural networks give rise to behavior,” said Dzirasa, the A. Eugene and Marie Washington Presidential Distinguished Professor of Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences.
New rules for used prosthetic feet could curb ‘medical equipment graveyards’
Researchers have proposed new standards into the decades-old prosthetic donations market, improving the quality of lower limb prosthetic feet by two-thirds—a major quality of life boost for recipients.
An interdisciplinary team of charities, prosthetists and academics led by King’s College London designed and implemented the very first set of standardized regulations for exporting prosthetic feet to the Global South, reducing unusable donations from 16% to 5%.
In so doing, the team have laid the foundation for improved prosthetics provision in the UK and an ethical framework for a global circular economy of prosthetics—the first of its kind.
Revolutionary Muscle & Fat Therapies: Future of Body Augmentation
This gene therapy company says its muscle-building treatment could last around 5 years.
The surprising part?
They believe the fastest path to market may be cosmetic enhancement using consumer demand to accelerate therapies for frailty and age-related muscle loss.
It’s not just deep sleep: Anesthesia drives brain into a strange state doctors are only beginning to map
People often describe anesthesia as something that puts a patient in a “deep sleep.” An anesthesiologist enters the operating room, and part of their mission is to ensure that the patient is completely unaware of what is happening around them until they wake up, often several hours later. Scientists and doctors have long debated what happens to the brain under anesthetic drugs during a surgical procedure.
A new study by Yale School of Medicine’s Departments of Anesthesiology and Neurology published on May 11, 2026, in Proceedings of the National Academy of Sciences uncovers new insights which may change the way we describe being under anesthesia. The study, “Spectral mapping reveals a resemblance of the anesthetic brain state to both sleep and coma,” reveals that being anesthetized may be more than simply being “put to sleep.” It can potentially carry more similarities to being in a coma than we originally thought.
A new approach to cancer vaccination yields more powerful T cells
MIT engineers have developed a new way to amplify the T-cell response to mRNA vaccines—an advance that could lead to much more powerful cancer vaccines and stronger protection against infectious diseases.
Most vaccines generate both antibodies and T cells that can target the vaccine antigen by activating antigen-presenting cells, such as dendritic cells. In this study, the researchers boosted the T-cell response with a new type of vaccine adjuvant (a material that can help stimulate the immune system). The new adjuvant consists of mRNA molecules encoding genes that turn on immune signaling pathways and promote a supercharged T-cell response.
In studies in mice, this mRNA-encoded adjuvant enabled the immune system to completely eradicate most tumors, either on its own or delivered along with a tumor antigen. The adjuvant also boosted the T-cell response to vaccines against influenza and COVID-19.
Pharmacological strategies targeting hepatocyte-mediated crosstalk in liver fibrosis
Liver fibrosis is a common pathological outcome of chronic liver injury. Many therapeutic agents show limited clinical efficacy or significant adverse effects due to the complex pathogenesis of liver fibrosis. This challenge underscores the urgent need to identify potential therapeutic targets and improve existing therapies. Hepatocytes serve as pivotal initiators of liver fibrosis that actively engage in signaling crosstalk with other hepatic cell types to promote fibrogenesis. Advances in understanding hepatocyte-centered signaling crosstalk have enabled the identification of potential therapeutic targets. Furthermore, combination therapies that regulate multiple pathways and drug modifications that improve pharmacological properties may help to minimize adverse effects and enhance the efficacy of existing treatments.
Regulation of neuronal invasion of small cell lung cancer by STMN2/β-alanine-controlled metabolic reprogramming
Zhou et al. demonstrate that perineural invasion (PNI) is an adverse prognostic factor in small cell lung cancer. They identify a neuron-STMN2-β-alanine axis, where the neural microenvironment upregulates STMN2 in tumor cells, reprogramming β-alanine metabolism to enhance cell migration and drive neural invasion, revealing a potential therapeutic target.
Neurotransmitter-activated GPCR signaling in myelin plasticity
Myelination is increasingly recognized as a dynamic and adaptive process regulated by oligodendrocytes throughout life. Beyond providing electrical insulation, myelin supports axonal metabolism and may serve as an energy reservoir under metabolic stress, highlighting the importance of physiological myelin turnover. Dysregulation of myelin dynamics contributes to a wide spectrum of neurological disorders, including demyelinating, neurodegenerative, and neuropsychiatric diseases. Growing evidence indicates that neurotransmitter signaling through G protein-coupled receptors (GPCRs) expressed by oligodendrocyte lineage cells regulates myelin formation, remodeling, and repair.