Lifeboat Foundation

MaxCyte, Inc., a leading, cell-engineering focused company providing enabling platform technologies to advance the discovery, development and commercialization of next-generation cell-based therapeutics and to support innovative, cell-based research, today announced the signing of a strategic partnership with Prime Medicine, Inc., a biotechnology company committed to delivering a new class of differentiated one-time curative genetic therapies.

Black hair? Green eyes? More than 160 genes determine your coloration, and their interactions are incredibly complicated.

Multiple sclerosis (MS) can cause a huge range of symptoms in different patients, and the severity can vary dramatically. It is an inflammatory condition in which the body attacks myelin sheaths, a protective insulation surrounding nerve cells. This can cause fatigue, pain, paralysis, and symptoms that gradually get worse. MS can be very difficult to diagnose because the symptoms can be so different in different patients, and the presence of brain lesions is the clearest indication of the disease. MRIs that can reveal those brain lesions are only useful once the disease have progressed to the point of brain damage, however.

The innate immune system presents a potential option for monitoring the progression of MS. The disease causes inflammation, so researchers tracked immune cells in the brain called macrophages, and assessed brain inflammation in a mouse model of MS. The findings have been reported in Science Translational Medicine.

Often seen negatively cannabis seen truthfully is a miracle plant even derivatives like cbd have cured some of the hardest mental disorders to cure like dementia alleviating symptoms to bring a person closer to health than before. Also now with this study veterans often seen incurable due to the unknown factors of ptsd and unknown factors of the human brain now are seeing relief through cannabis usage in a therapeutic setting 😀 Even the plant itself is some sorta miracle plant alleviating some thought incurable diseases.

Milekic’s morning could be an advertisement for the potential of AI to transform health care. Mount Sinai is among a group of elite hospitals pouring hundreds of millions of dollars into AI software and education, turning their institutions into laboratories for this technology. They’re buoyed by a growing body of scientific literature, such as a recent study finding AI readings of mammograms detected 20 percent more cases of breast cancer than radiologists — along with the conviction that AI is the future of medicine.

Researchers are also working to translate generative AI, which backs tools that can create words, sounds and text, into a hospital setting. Mount Sinai has deployed a group of… More.

Mount Sinai and other elite hospitals are pouring millions of dollars into chatbots and AI tools, as doctors and nurses worry the technology will upend their jobs.

Summary: Probiotics might play a vital role in preventing cognitive decline associated with aging. By providing participants suffering from mild cognitive impairment with the probiotic Lactobacillus rhamnosus GG for three months, researchers observed enhanced cognitive performance and gut microbiome modifications.

The study suggests that altering gut microbiome might be a strategic approach to enhancing cognitive function in individuals with mild cognitive impairment. If replicated, these findings could revolutionize preventive strategies in cognitive health using gut microbiome-focused approaches.

Lawrence J. Appel, MD, MPH, is the director of the Welch Center for Prevention, Epidemiology, and Clinical Research at Johns Hopkins University. His clinical research focuses on preventing blood pressure-related cardiovascular and kidney diseases. Here, he discusses the link between high blood pressure and kidney disease, and the importance of early detection and management.

Q: What is the link between kidney disease and high blood pressure?

A: High blood pressure is a leading cause for many adverse conditions, such as stroke, heart disease, heart failure, and possibly cognitive decline. Many patients are unaware of the link between elevated blood pressure and kidney disease.

A change in just one letter in the code that makes up a cancer-causing gene can significantly affect how aggressive a tumor is or how well a patient with cancer responds to a particular therapy. A new, very precise gene-editing tool created by Weill Cornell Medicine investigators will enable scientists to study the impact of these specific genetic changes in preclinical models rather than being limited to more broadly targeted tactics, such as deleting the entire gene.

The tool was described in a study published Aug. 10 in Nature Biotechnology. Dr. Lukas Dow, an associate professor of biochemistry in medicine at Weill Cornell Medicine, and his colleagues genetically engineered mice to carry an enzyme that allows the scientists to change a single base or “letter” in the mouse’s genetic code. The enzyme can be turned on or off by feeding the mice an antibiotic called doxycycline, reducing the prospect of unintended genetic changes occurring over time. The tool can also grow miniature versions of intestine, lung, and pancreas tissue called organoids from the mice, enabling even more molecular and biochemical studies of the impact of these precise genetic changes.

“We are excited about using this technology to try and understand the genetic changes that influence a patient’s response to cancer therapies,” said Dr. Dow, who is also a member of the Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine.

A healthy immune system: the ultimate balancing act

The immune system is comprised of innate and adaptive immune responses, both of which are crucial in maintaining our health. The innate immune response is the first line of defense that immediately works to prevent the spread of pathogens and tumors.¹ The adaptive immune response is a more sophisticated, secondary response that is specialized to clear specific pathogens and provide long-lasting immunity.²

The efficacy of these two systems depends on balanced inflammatory and anti-inflammatory responses, referred to as immunomodulation. For example, upon injury or infection, macrophages secrete molecules that promote inflammation to dilate blood vessels and recruit other immune cells to the damaged site. Once the infection is cleared, the immune system mounts an anti-inflammatory, reparatory response.