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Some bacteria in the mouth may play a role in memory loss and dementia

As people age, their memory and thinking skills naturally decline. Approximately 15% of older adults experience mild cognitive impairment, a major risk factor for dementia and other forms of dementia such as Alzheimer’s disease.

Since cognitive decline and dementia are growing public health concerns, scientists are working to better understand the risk factors and find ways to reduce them. One emerging area of research suggests that oral health may play a role in brain health.

Now, a new study suggests that the bacteria living in the mouth may influence cognitive function as people age, with some harmful bacteria possibly contributing to the development of dementia and Alzheimer’s disease.

Complex model of molecular ‘wear-and-tear’ shines light on how proteins age

Chromatin, the mix of DNA and protein that houses each cell’s genome, is more resilient to aging than previously thought, suggests a study published in the Journal of the American Chemical Society by researchers at King’s College London.

Scientists believe this may reveal how the body can cope with the inevitable “wear-and-tear” of aging and where it may be more vulnerable to its effects, laying the groundwork for future anti-aging treatments throughout the body.

Proteins, much like the rest of the body, change when aging. This is especially the case for the that make up , which may “live” for ~100 days before being replenished and replaced. During their lifetime, proteins are stretched and distorted, or experience processes that are similar to rusting. This damage results in naturally occurring to the protein called post-translational modifications, or PTMs.

Test of ‘Poisoned Dataset’ shows Vulnerability of LLMs to Medical Misinformation

For their study published in the journal Nature Medicine, the group generated thousands of articles containing misinformation and inserted them into an AI training dataset and conducted general LLM queries to see how often the misinformation appeared.

Prior research and anecdotal evidence have shown that the answers given by LLMs such as ChatGPT are not always correct and, in fact, are sometimes wildly off-base. Prior research has also shown that misinformation planted intentionally on well-known internet sites can show up in generalized chatbot queries. In this new study, the research team wanted to know how easy or difficult it might be for malignant actors to poison LLM responses.

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