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Japanese scientists are reportedly set to start human trials for a drug that can regrow teeth. All being well, the clinical trial will start next year and a tooth regeneration therapy could be ready for people with holey smiles as early as 2030, according to Japanese media.

Back in 2021, a team from the Graduate School of Medicine at Kyoto University published promising research that showed a protein called USAG-1 limits the growth of teeth in mice. By turning off the gene that codes for the production of the protein, the mice were able to freely regrow their teeth.

They were then able to create a neutralizing antibody drug therapy that was able to block the protein’s function, stimulating the mice into growing new sets of teeth. Later experiments showed the same benefits in ferrets, which have a more similar dental pattern to humans.

How are independent distributors assisting manufacturers and identifying ways to reduce electronic component costs? By Del Williams.

Repost, but if you know someone’s dealing with such, the information can help you and them. The suppressing of it can not help anyone.

Alzheimer’s disease varies widely in its age of onset, presentation, and severity. Recently, the SORL1 gene has received increased attention since variations in this gene have been associated with both early-and late-onset Alzheimer’s. However, little is known about how damage to SORL1 leads to disease.

Using stem cells from patients with Alzheimer’s, investigators from Harvard-affiliated Brigham and Women’s Hospital found that loss of normal SORL1 function leads to a reduction in two key proteins known to be involved in Alzheimer’s and which play an essential role in the neurons of healthy individuals.

Continue reading “‘Molecular road’ to Alzheimer’s leads to new treatment strategy” »

The last 2 questions and the answers are great. The first starts at 30 minutes. And I like his answer to the 2nd question especially, the time is 33:54. “What is giving me great hope is that we’re entering the phases where we have more than enough tools to get really get close to escape velocity.”

Genome Engineering for Healthy Longevity – George Church at Longevity Summit Dublin 2023.

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Educators just started recovering from the profound impact of the COVID-19 pandemic. Some studies assess that the learning loss may never be recovered. However, a new challenge has crashed on the shores of education — AI — which could be even more impactful. In this post, we look at the challenges that AI brings to education, some ideas, and steps being taken.

A look at the newly announced Generative AI guidance from UNESCO, and others. An explanation of what they mean for application.

The patch can calibrate the glucose measurements based on the pH and temperature changes in sweat due to factors such as exercise and eating.

A team of researchers at Penn State has developed a new wearable patch that can monitor your health by analyzing your sweat. The patch, which is made of a special material that can detect glucose, pH, and temperature in sweat, can provide valuable information about your body’s condition and help diagnose and manage diseases such as diabetes.

Credit: Kate Myers/Penn State.

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This lightweight material surpasses the strength of steel.

There is a high demand for strong yet lightweight materials across diverse industries, including defense, medical devices, and automotive sectors, among others.

Material scientists have been investigating the possibilities of unconventional components in order to meet this growing demand and enhance technological advancements.

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Citation information is sourced from Crossref Cited-by service.

In a recent study led by Lei Jiang, Ph.D., an assistant professor of molecular and cellular endocrinology, a team of researchers from City of Hope and the University of Texas Southwestern Medical Center, found a potential new target for treating patients with metastatic cancer. Their findings were published in the August 29 issue of the journal Cell Rep orts.

The goal of the team’s study was to elucidate the role of reductive carboxylation in redox metabolism, a process believed to be important for metastatic cancer. Reductive carboxylation is best known as a metabolic pathway that provides a molecule called acetyl-CoA so that it can be turned into lipids, which is mediated by fatty acid synthase (FASN). The FASN-mediated lipogenesis process supports rapid growth in most proliferating cancer cells, and increased FASN expression has been viewed as a metabolic feature of cancer cells. Thus, FASN is considered a potential target to block tumor growth.

New research has identified that preventing the metabolic adaptations needed for cancer to metastasize could provide a target for treating patients with metastatic cancer.

Continue reading “Potential New Treatment Target for Metastatic Cancer Identified” »