Lifeboat Foundation

The challenge: There are very few ways to slow down Alzheimer’s disease or treat its symptoms, and there’s no cure — in 2021, nearly 120,000 Americans died from Alzheimer’s complications, making it one of the top 10 leading causes of death.

One genetic variant in particular — called APOE-e4 — is strongly tied to the brain disease. Having one copy makes a person 2–3 times more likely to develop Alzheimer’s, while having two copies (one from each parent) increases the risk by 8–12 times.

Rohit Singla, an MD/PhD student, shares how his training in both medicine and engineering is allowing him to identify complex problems, understand the nuances within them and tackle those complex problems with elegant solutions that are the right fit for patients with kidney disease. Using data from over 10,000 cases, he is creating artificial intelligence tools to automatically detect microscopic changes in the kidney structure and develop new treatments to improve people’s lives.

Produced by UBC faculty of medicine development and alumni engagement.

Continue reading “Aspire #02 — Rohit Singla: Using AI to Develop New Treatments in Kidney Disease” »

For more information on addiction services at #YaleMedicine, visit: https://www.yalemedicine.org/departments/program-in-addiction-medicine.

Written and produced by Yale Neuroscience PhD student Clara Liao.

Continue reading “How an Addicted Brain Works” »

Speech BCIs that use brain implants and algorithms to translate brain signals into text are changing the lives of people with paralysis.

Two-photon polymerization is a potential method for nanofabrication to integrate nanomaterials based on femtosecond laser-based methods. Challenges in the field of 3D nanoprinting include slow layer-by-layer printing and limited material options as a result of laser-matter interactions.

In a new report now on Science Advances, Chenqi Yi and a team of scientists in Technology Sciences, Medicine, and Industrial Engineering at the Wuhan University China and the Purdue University U.S., showed a new 3D nanoprinting approach known as free-space nanoprinting by using an optical force brush.

This concept allowed them to develop precise and spatial writing paths beyond optical limits to form 4D functional structures. The method facilitated the rapid aggregation and solidification of radicals to facilitate polymerization with increased sensitivity to laser energy, to provide high accuracy, free-space painting much like Chinese brush painting on paper.

#medicalAI

Generative AI for medical imaging can create infinite synthetic images of the human anatomy. These large, synthetic datasets are used for training generalizable AI models that can learn from evolving patient data while preserving patient privacy. Learn how MONAI, a framework for building and deploying medical AI, and partners like King’s College London, Mount Sinai, and East River Imaging are using generative AI to study disease and make AI decisions and predictions more accurate, trusted, and safe.

This video is about How ChatGPT/ AI can disrupt healthcare.

ChatGPT is an AI-powered chat platform developed by OpenAI. It allows users to ask questions in a conversational format and build on previous conversations, which allows for improved learning over time. Microsoft has invested billions of dollars in ChatGPT, integrating it into their search engine Bing and web browser Edge. Although the rise of AI has caused concern over job security, ChatGPT currently requires human input to generate questions and diagnose patients, making it a tool to augment human abilities in healthcare. The technology can be used for diagnosis, research, medical education, and radiographs. It can assist healthcare professionals in diagnosing and researching diseases, visualizing anatomy and procedures, and analyzing medical images.

Continue reading “ChatGPT AI in HEALTHCARE? Innovation and disruption” »

A quickie about E5.

Hello, i am back! Blood, sweat and tears have been shed these past months of absence. But enough sweating was done during the summer, tears have already been shed, so that just leaves me with blood. And whether taking a part of blood (plasma) and injecting it into old animals is enough for rejuvenation. That’s right, many of you may remember, earlier this year i made a video on the oldest living rat.- and now we have some updates: in particular, (i) what actually were the rats given, and (ii) what changes were seen, showing both some DNAm and glycan age data.

Continue reading “Pig plasma to live longer?” »

A new public database built from the ground up by Washington State University undergraduates looks to expedite scientific understanding of how skin heals.

The website — skinregeneration.org — was created for researchers but allows anyone to cross-compare information on more than 33,000 genes from different species as they relate to skin development, wound repair, and regeneration. Ultimately, it could help scientists reprogram adult skin for regeneration during wound healing and to inhibit the aging process.

“Historically, one of the major mechanisms scientists communicated through was with physical papers published in journals. A new concept of how to output knowledge is to create webtools in association with online manuscripts. For example, webtools that allow for interacting with large genomic datasets that have so much knowledge that cannot fit into a single paper. You can just interact with the data on any device and at any time you want,” said Ryan Driskell, head of WSU’s Fibroblast and Skin Regeneration Laboratory.