Lifeboat Foundation

New case report worth reading! A patient underwent subtotal cholecystectomy for severe cholecystitis. Post-op he developed jaundice and abscess requiring percutaneous transhepatic drainage (PTAD).

Shock and massive hemothorax occurred after removal of the PTAD tube. The cause was bleeding from the liver at the PTAD site. The patient required emergency hemostasis and embolization. This highlights the need for extreme care when handling PTAD tubes after complicated gallbladder surgery.

A 59-year-old man with a past medical history of gallstones was diagnosed with acute cholecystitis and received antibiotic treatment. He was discharged after ten days of hospitalization and was due to undergo laparoscopic cholecystectomy. Three months later, however, he had to be readmitted due to a recurrence of acute cholecystitis. Subsequently, laparoscopic reconstituting subtotal cholecystectomy was performed because Inflammation of the gallbladder was severe. At the first postoperative outpatient visit, the patient reported obstructive jaundice, and computed tomography (CT) scan revealed fluid collection in the hepatic bed and a missed common bile duct stone. Percutaneous transhepatic abscess drainage (PTAD) was performed on admission, and endoscopic stone removal was attempted the following day but was challenging due to a periampullary diverticulum.

Continue reading “Massive Hemothorax Caused by Removal of Percutaneous Transhepatic Abscess Drainage Tube for Bile Leak After Subtotal Cholecystectomy: A Case Report” »

Of course, this study was performed on a relatively small group of individuals in an agricultural community, which is not the environment that most American teenagers grow up in. These links may also be due to some other confounding factors, like spending more time on the farm than in formal education. However, these results are still striking and important to consider for young people in farming communities (and non-farming communities) around the world.

“Many chronic diseases and mental-health disorders in adolescents and young adults have increased over the last two decades worldwide, and exposure to neurotoxic contaminants in the environment could explain a part of this increase,” senior author Jose Ricardo Suarez, an associate professor in the Herbert Wertheim School of Public Health, said in a statement.

“Hundreds of new chemicals are released into the market each year, and more than 80,000 chemicals are registered for use today,” Suarez added. “Sadly, very little is known about the safety and long-term effects on humans for most of these chemicals. Additional research is needed to truly understand the impact.”

The positron, the antiparticle of the electron, has the same mass and charge as that of an electron but with the sign flipped for the charge. It is an attractive particle for scientists because the use of positrons has led to important insights and developments in the fields of elementary particle physics, atomic physics, materials science, astrophysics, and medicine.

For instance, positrons are known to be components of antimatter. They are also powerful in detecting lattice defects in solids and semiconductors and in structural analysis of the topmost surface of crystals.

Positronic compounds, namely bound states of positrons with regular atoms, molecules, or ions, represent an intriguing aspect of positron –matter interactions and have been studied experimentally via observation of positron annihilation in gases. It may be possible to generate new molecules and ions via the formation of positron compounds, but no research has ever been done from such a perspective.

Did you know (RA) is a long-lasting autoimmune disease that affects joints? The immune system is meant to protect us, but with RA, it attacks healthy tissue. This can cause pain, swelling, stiffness, and loss of joint function.

Caring for yourself when living with RA includes knowing when to rest and when to exercise, occasionally wearing a splint, and managing stress levels.

Find more tips for coping with RA from NIAMS:

Continue reading “Rheumatoid Arthritis: Diagnosis, Treatment, and Steps to Take” »

Imagine that the human body is a… More.

How a Small Strand of RNA is Key to Fighting #Cancer.

Called let-7, the microRNA governs formation of the cellular memory pool and is a gift from the dawn of animal life. A team of researchers at the University of Massachusetts Amherst has shown that a single, small strand of microRNA, or miRNA, known as let-7, governs the ability of T-cells to recognize and remember tumor cells. This cellular memory is the basis for how vaccines work. Boosting cellular memory to recognize tumors could help improve cancer therapies. The research, published recently in Nature Communications, suggests a new strategy for the next generation of cancer-fighting immunotherapies.

Continue reading “How a Small Strand of RNA is Key to Fighting Cancer” »

A new Yale study finds low ejectionfraction – the amount of blood your heart pumps out with each beat – is associated with worse cardiovascular outcomes for patients with peripheral artery disease (PAD):

You can learn more about important PAD risk factors here: https://brnw.ch/21wDlIR

Peripheral arterial disease (PAD) is commonly associated with coronary artery disease (CAD), and echocardiography is frequently performed prior to lower extremity revascularization (LER). However, the incidence of various echocardiographic findings in patients with PAD and their impact on the outcomes of LER has not been well studied.

“Cancer” is not a word we want to hear. Conversations with your doctor about cancer can induce fear, anxiety, and a plethora of other emotions. But what if your doctor uses the phrase This terminology will probably still make a lot of people anxious and, in some situations, could result in some unnecessary treatment.

Several types of malignancies are associated with conditions that, while benign, could infer a more significant risk or likelihood of developing cancer in the future. Terminology including lesions, “stage 0” disease, or carcinoma “in situ” can all describe an abnormal, yet not malignant, finding. In addition to fear, these diagnoses can undoubtedly lead to patient confusion.

A diagnosis indicates abnormal cells present in a single location in the body. If a lesion isous, it has not spread to any other tissue, distant or nearby. This explains why theous conditions associated with several cancer types have names that involve the phrase “in situ,” which means “in its original place.”

This is a bit technical. “nucleocytoplasmic compartmentalization assay”, Yeah buddy.

Life is dependent on the preservation and storage of information. The genome and epigenome are the two central storehouses of information in eukaryotes, and although they work interdependently, they are fundamentally quite different. Genetic information is consistent across all body cells throughout the life of an individual while epigenetic information varies between cells as well as changes over time and as per environment.

Researchers have identified several hallmarks of aging such as epigenetic alterations, genomic instability, cellular senescence, telomere attrition, mitochondrial dysfunction, and others [1]. These are known to play a role in the dysfunction and deterioration of cells with age. David Sinclair and other researchers have previously indicated that loss of epigenetic information can cause changes in gene expression, leading to cellular identity loss. Previous studies in mice have also shown that cell injuries such as cell crushing and DNA double-strand breaks can promote loss of epigenetic information which can accelerate aging along with age-related diseases [2].

Continue reading “Is the reversal of cellular aging possible through chemical means?” »

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Continue reading “Did DunedinPACE Improve For Test #5 in 2023? Also, Is NAD Significantly Correlated With DunedinPACE?” »