A recent study published in the journal Aging by Julia Michalkiewicz, Tung D. Nguyen, and Monica Y. Lee from the University of Illinois at Chicago College of Medicine underscores the essential role of the protein Nucleoporin93 (Nup93) in preserving blood vessel health during aging. The authors discuss emerging research that identifies Nup93 as a potential therapeutic target for preventing or mitigating aging-related conditions such as heart disease and stroke.
Cardiovascular diseases remain the leading causes of death worldwide, with aging identified as a major risk factor. Vascular health declines as endothelial cells (EC)—the protective lining of blood vessels—lose their functionality with age. This deterioration leads to inflammation, arterial stiffening, and reduced blood flow, significantly increasing the risk of life-threatening diseases. The authors underscore the urgent need to uncover the molecular mechanisms driving these changes.
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