Lifeboat Foundation

Researchers at Baylor College of Medicine and Rice University received a grant for more than $3.9 million over five years from the National Institutes of Health’s Office of Research Infrastructure Programs to establish the Baylor/Rice Genome Editing Testing Center (GETC). The new center will assist investigators from across the country with somatic cell genome editing experiments in mouse models.

Somatic cell genome editing, the ability to edit DNA within the body’s non-reproductive cells, is a promising potential treatment for the most severe human diseases. Over the last decade, significant effort has gone into developing more effective genome editing systems and methods of delivery to specific cells and organs. However, many of these new technologies do not progress to use in humans because there is insufficient evidence from animal models supporting their effectiveness.

“Our center will provide mouse model resources and genome editing testing pipelines to researchers who are developing new genome editing and delivery technologies but need assistance with conducting preclinical animal studies,” said Dr. Jason Heaney, co-principal investigator and associate professor of molecular and human genetics at Baylor. “Our goal is to help generate the animal model data needed to demonstrate the therapeutic potential of these cutting-edge technologies.”

Abstract: Full Publication #OpenAccess.

Scalable fabrication of two-dimensional (2D) arrays of quantum dots (QDs) and quantum rods (QRs) with nanoscale precision is required for numerous device applications. However, self-assembly–based fabrication of such arrays using DNA origami typically suffers from low yield due to inefficient QD and QR DNA functionalization. In addition, it is challenging to organize solution-assembled DNA origami arrays on 2D device substrates while maintaining their structural fidelity. Here, we reduced manufacturing time from a few days to a few minutes by preparing high-density and rehydration process. We used a surface-assisted large-scale assembly (SALSA) method to construct 2D origami lattices directly on solid substrates to template QD and QR 2D arrays with orientational control, with overall loading yields exceeding 90%. Our fabrication approach enables the scalable, high fidelity manufacturing of 2D addressable QDs and QRs with nanoscale orientational and spacing control for functional 2D photonic devices.

Dehydration and surface-assisted assembly enable rapid, scalable quantum dot and quantum rod 2D arrays with nanoscale precision.

Gene therapy company Genflow Biosciences has received positive feedback from Belgium’s Federal Agency for Medicines and Health Products as it seeks to move into human clinical trials. Genflow is developing gene therapies that target the aging process, with a focus on reducing and delaying age-related diseases.

Genflow’s approach involves the use of adeno-associated virus (AAV) vectors to deliver copies of the Sirtuin-6 (SIRT6) gene variant found in centenarians into cells. Sirtuins are a group of proteins that play a vital role in regulating various cellular processes. In recent years, SIRT6 has gained attention for its potential role in promoting healthy aging.

Genflow says it has received written advice from the FAHMP to commence clinical trials of its lead compound (GF-1002) in patients suffering from NASH, an aggressive form of non-alcoholic fatty liver disease, rather than in healthy volunteers. While further discussions and agreement with the European Medicine Agency (EMA) are still required, Genflow says that it expects a NASH clinical trial to commence in approximately 18 months.

In a recent study, scientists stained the DNA of this worm hatchling to hunt down segments of DNA that they’d seen deleted from its genome earlier in development. The deleted fragments (red) survive only in germline cells in the worm’s gonads.

To figure out what was going on, Delattre’s lab looked at the DNA of an adult worm. The researchers compared the genomes of M. belari’s germline cells — the specialized reproductive cells like sperm and eggs — with the genomes of the worm’s somatic (nonreproductive) cells. The somatic genomes were missing long strings of sequences present in germline genomes. Sometime between the embryo’s growth from seven cells to 32, huge chunks of DNA had vanished.

The scientists then watched nematode embryos develop under a microscope. As the cells grew and replicated their genomes, they broke 20 chromosomes down into fragments and then reassembled them into 40 miniature chromosomes. Most of the fragments rejoined in this new, smaller genome — but a substantial fraction were left out.

Continue reading “To Defend the Genome, These Cells Destroy Their Own DNA” »

That’s good news if it becomes successful! Cancer is such an awful disease.

There’ll be an app for that.

Curing cancer could soon be as easy as a few taps on your mobile, according to a team of scientists at Rice University who have received $45 million in funding for a novel, implant-based treatment system that could cut cancer death rates by 50%.

Continue reading “Scientists developing implant to cure cancer in just 60 days — with goal to slash death rates by 50%” »

Japanese scientists are reportedly set to start human trials for a drug that can regrow teeth. All being well, the clinical trial will start next year and a tooth regeneration therapy could be ready for people with holey smiles as early as 2030, according to Japanese media.

Back in 2021, a team from the Graduate School of Medicine at Kyoto University published promising research that showed a protein called USAG-1 limits the growth of teeth in mice. By turning off the gene that codes for the production of the protein, the mice were able to freely regrow their teeth.

They were then able to create a neutralizing antibody drug therapy that was able to block the protein’s function, stimulating the mice into growing new sets of teeth. Later experiments showed the same benefits in ferrets, which have a more similar dental pattern to humans.

How are independent distributors assisting manufacturers and identifying ways to reduce electronic component costs? By Del Williams.

Repost, but if you know someone’s dealing with such, the information can help you and them. The suppressing of it can not help anyone.

Alzheimer’s disease varies widely in its age of onset, presentation, and severity. Recently, the SORL1 gene has received increased attention since variations in this gene have been associated with both early-and late-onset Alzheimer’s. However, little is known about how damage to SORL1 leads to disease.

Using stem cells from patients with Alzheimer’s, investigators from Harvard-affiliated Brigham and Women’s Hospital found that loss of normal SORL1 function leads to a reduction in two key proteins known to be involved in Alzheimer’s and which play an essential role in the neurons of healthy individuals.

Continue reading “‘Molecular road’ to Alzheimer’s leads to new treatment strategy” »

The last 2 questions and the answers are great. The first starts at 30 minutes. And I like his answer to the 2nd question especially, the time is 33:54. “What is giving me great hope is that we’re entering the phases where we have more than enough tools to get really get close to escape velocity.”

Genome Engineering for Healthy Longevity – George Church at Longevity Summit Dublin 2023.

Continue reading “Longevity Summit Dublin” »