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Boosting Mitochondrial Quality Control to Combat Alzheimers

Scientists at the École polytechnique fédérale de Lausanne (EPFL) have found a way to make mitochondria more resistant to damage, which could potentially be used to halt Alzheimer’s and other, similar, diseases.

Globally, Alzheimer’s disease is the most common form of dementia and cause of neurodegeneration. It causes brain damage and symptoms such as long-term memory loss. It is an amyloid-based disease, with the characteristic hallmark being the formation of toxic plaques in the brain made from the aggregated beta-amyloid inside the neurons.

Scientists Have Tried First-Ever Gene Editing Directly Inside a Patient’s Body

In a bold first-of-its-kind experiment, scientists have edited a person’s genes directly inside living tissue in an ambitious bid to cure a man of a rare, crippling genetic disorder.

While CRISPR has broken ground in things like editing human embryos and injecting patients with genetically edited cells, this alternative technique pioneers a new real-time approach to infusing a person’s blood with a gene-editing virus.

“For the first time, a patient has received a therapy intended to precisely edit the DNA of cells directly inside the body,” says CEO of Sangamo Therapeutics, Sandy Macrae, whose company is testing the experimental procedure.

For the First Time, a Robot Passed a Medical Licensing Exam

Chinese AI-powered robot Xiaoyi took the country’s medical licensing examinations and passed, according to local reports. Xiaoyi is just one example of how much China is keen on using AI to make a number of industries more efficient.

Experts generally agree that, before we might consider artificial intelligence (AI) to be truly intelligent —that is, on a level on par with human cognition— AI agents have to pass a number of tests. And while this is still a work in progress, AIs have been busy passing other kinds of tests.

Algorithm better at diagnosing pneumonia than radiologists

Stanford researchers have developed an that offers diagnoses based off chest X-ray images. It can diagnose up to 14 types of medical conditions and is able to diagnose pneumonia better than expert radiologists working alone.

A paper about the algorithm, called CheXNet, was published Nov. 14 on the open-access, scientific preprint website arXiv.

“Interpreting X-ray images to diagnose pathologies like pneumonia is very challenging, and we know that there’s a lot of variability in the diagnoses radiologists arrive at,” said Pranav Rajpurkar, a graduate student in the Machine Learning Group at Stanford and co-lead author of the paper. “We became interested in developing machine learning algorithms that could learn from hundreds of thousands of chest X-ray diagnoses and make accurate diagnoses.”

Science Is Starting to Explore the Gray Zone Between Life and Death

Biologist Mark Roth, at Seattle’s Fred Hutchinson Cancer Research Center, is working with animal subjects, putting them into suspended animation. The idea is that a patient who is in medical crisis could be put into a suspended state like hibernation, until he or she could be stabilized and in this way, get past it.

Though we tend to expire when the oxygen level is low, many animals go into a suspended state in extremely low oxygen environments. In the lab, one must enter into such an environment quickly. Roth is currently working with nematodes—a kind of roundworm—and expects to eventually work up to humans.

A vegetative state is another aspect of what we consider the gray zone between life and death. Medically, this is when sufficient damage to the brain has occurred, where the person isn’t aware of and can’t respond to their surroundings. They may breathe, have a heartbeat, move their eyes, even show reflexes, but they can’t respond to stimuli or interact with the world. Their brain stem is operating normally, but other parts of the brain may be damaged or inoperable. Most patients who enter such a state never leave it.

Researchers Created a Platform That Prints With Living Matter

3D printing has come a long way. In a new study, scientists explore the potential of using bacteria-laced ink to print living materials.

From pizza to urine-based space plastic and even blood vessels, it seems there’s no limit to what can be 3D printed. A new 3D printing platform, created by ETH researchers led by Professor André Studart, head of the Laboratory for Complex Materials, is advancing the process by working with living materials. The specially designed material is actually an ink infused with bacteria. The machine is then able to print living biochemical designs for a wide variety of purposes, which vary depending on the bacteria used. Their research has been published in Science Advances.

A Modified CRISPR Could Treat Common Diseases Without Editing DNA

It worked. Working with mice, they were able to reverse the disease symptoms of kidney disease, type 1 diabetes, and a form of muscular dystrophy. In the mouse with kidney disease, for example, they turned on two genes associated with kidney function and saw the kidney function improved.


The unassumingly named CRISPR/Cas9 is a technology that stands to remake the world as we know it. By allowing scientists to more easily than ever cut and paste all those As, Cs, Ts, and Gs that encode all the world’s living things, for one thing, it could one day cure many devastating diseases.

All that power, though, comes with one pretty sizable caveat: Sometimes CRISPR doesn’t work quite like we expect it to. While the scientific establishment is still embroiled in a debate over just how serious the problem is, CRISPR sometimes causes off-target effects. And for scientists doing gene editing on human patients, those mutations could wind up inadvertently causing problems like tumors or genetic disease. Yikes.