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NEURD: A new software to proofread the map of the brain

A revolutionary blueprint is emerging from a fragment of brain tissue, promising new insights into the mysteries of the human mind. At the heart of this innovation is NEURD—short for “NEURal Decomposition”—a groundbreaking software package developed by researchers at Baylor College of Medicine.

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With NEURD, the time-consuming process of mapping the intricate “street map” of brain connections is being transformed, enabling faster error detection and data corrections that pave the way for discovery.

Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing

Ageing is a scientifically fascinating and complex biological occurrence characterised by morphological and functional changes due to accumulated molecular and cellular damage impairing tissue and organ function. Ageing is often accompanied by cognitive decline but is also the biggest known risk factor for Alzheimer’s disease, the most common form of dementia. Emerging evidence suggests that sedentary and unhealthy lifestyles accelerate brain ageing, while regular physical activity, high cardiorespiratory fitness (CRF), or a combination of both, can mitigate cognitive impairment and reduce dementia risk.

Vaibhav Sisinty (@vaibhavsisinty) • Instagram reel

17K likes, — vaibhavsisinty on March 27, 2025: “Your Future Kids Might Be Genetically Engineered🤯… [genetic engineering, CRISPR, designer babies, IVF, in vitro gametogenesis, gene editing, human evolution, bioethics, futuristic science, AI in healthcare, medical advancements, artificial reproduction, skin cell gametes, future tech, DNA modification, biotechnology]”

The Most Detailed Map of the Human Cell Ever Made — Powered by AI and Imaging

For the first time, scientists have built a detailed, interactive map of a human cell, revealing how thousands of proteins organize and work together.

Using advanced imaging and AI tools like GPT-4, they uncovered hundreds of previously unknown protein functions and identified key cellular assemblies tied to childhood cancers. This map not only changes how we study cell biology but could also transform our understanding of disease at the molecular level.

Mapping the Human Cell: A 400-Year Quest.

Moving forward from Cockcroft-Gault creatinine clearance to race-free estimated glomerular filtration rate to improve medication-related decision-making in adults across healthcare settings: A consensus of the National Kidney Foundation Workgroup for Implementation of Race-Free eGFR-Based Medication-Related Decisions

The NKF Workgroup for Implementation of Race-Free eGFR-Based Medication-Related Decisions suggests that health systems, health settings, clinical laboratories, electronic health record systems, compendia and data vendors, and healthcare practitioners involved with medication-related decision-making …

New mechanism to relieve mitochondrial stress

Lead author Joseph Silk, a professor in the Department of Physics and Astronomy at Johns Hopkins University, explained that this discovery could change our understanding of how galaxies formed. We know these monster black holes exist at the center of galaxies near our Milky Way, but the big surprise now is that they were present at the beginning of the universe as well and were almost like building blocks or seeds for early galaxies.

The study, published in the Astrophysical Journal Letters, analyzed distant galaxies from the early universe observed through the Webb telescope. These galaxies appeared much brighter than expected and contained unusually high numbers of young stars and supermassive black holes.

The findings challenge the conventional idea that black holes formed after the collapse of supermassive stars and that galaxies formed after the first stars appeared. Instead, the analysis suggests that black holes and galaxies coexisted and influenced each other’s development during the first 100 million years of the universe.

Cancer researchers identify the ‘switch’ that allows intestinal cells to regenerate after injury

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies for colorectal and other types of cancer.

Peter Dempsey, Ph.D., professor of pediatrics– in the CU School of Medicine, and Justin Brumbaugh, Ph.D., assistant professor of molecular, cellular, and developmental biology at CU Boulder, recently published a paper in the journal Nature Cell Biology showing the importance of the H3K36 methylation process in regulating plasticity and regeneration in intestinal cells.

“The intestine has an enormous ability to regenerate itself after injury, and it does this through a model of dedifferentiation,” Dempsey explains. “The cells dedifferentiate back into a type of regenerative stem cell after injury, and those eventually recover the intestine and turn back to normal cells.”

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