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Category: biotech/medical – Page 221

New findings on the power of enzymes could reshape biochemistry

Using a series of more than 1,000 X-ray snapshots of the shapeshifting of enzymes in action, researchers at Stanford University have illuminated one of the great mysteries of life—how enzymes are able to speed up life-sustaining biochemical reactions so dramatically. Their findings could impact fields ranging from basic science to drug discovery, and provoke a rethinking of how science is taught in the classroom.

“When I say enzymes speed up reactions, I mean as in a trillion-trillion times faster for some reactions,” noted senior author of the study, Dan Herschlag, professor of biochemistry in the School of Medicine. “Enzymes are really remarkable little machines, but our understanding of exactly how they work has been lacking.”

There are lots of ideas and theories that make sense, Herschlag said, but biochemists have not been able to translate those ideas into a specific understanding of the chemical and physical interactions responsible for enzymes’ enormous reaction rates. As a result, biochemists don’t have a basic understanding and, therefore, have been unable to predict rates or design new enzymes as well as nature does, an ability that would be impactful across industry and medicine.

AI model generates antimicrobial peptide structures for screening against treatment-resistant microbes

A team of microbiologists, chemists and pharmaceutical specialists at Shandong University, Guangzhou Medical University, Second Military Medical University and Qingdao University, all in China, has developed an AI model that generates antimicrobial peptide structures for screening against treatment-resistant microbes.

In their study published in the journal Science Advances, the group developed a compression method to reduce the number of elements needed in training data for an AI system, which helped to reduce diversification issues with current AI models.

Prior research has suggested that drug-resistant microbes are one of the most pressing problems in medical science. Researchers around the world have been looking for new ways to treat people infected with such microbes—one approach involves developing , which work by targeting bacterial membranes.

Scientists create hydrogen with no direct CO₂ emissions at source

A new way of creating hydrogen, which eliminates direct CO2 emissions at source, has been developed by an international team of scientists.

The process reacts hydrogen-rich and sustainably sourced bioethanol taken from agricultural waste with water at just 270°C using a new bimetallic catalyst. Unlike traditional methods, which operate between 400°C and 600°C, are energy-intensive and generate large amounts of CO2, the catalyst shifts the chemical reaction to create hydrogen without releasing as a byproduct.

Instead, the process co-produces high-value , an organic liquid used in , household cleaning products, manufacturing and medicine, and has an annual global consumption exceeding 15 million tons.

Eating yogurt may offer protection against hard-to-detect colon cancer

Beyond the general recommendation to consume yogurt, this research raises questions about which products might offer the most benefit. Not all yogurts contain the same bacterial strains or concentrations. While many products include Bifidobacterium, the amounts can vary significantly. Future research may help determine whether certain formulations provide better protection against colorectal cancer.

Different subtypes of colorectal cancer may respond differently to preventive measures, suggesting that a one-size-fits-all approach to prevention might not be optimal. This understanding could eventually lead to more personalized prevention strategies based on individual risk factors and gut bacterial composition.

A Nose-Computer Interface Could Turn Dogs Into Super Detectors

Thanks to their excellent smelling ability, dogs have been used for hundreds of years to hunt down wild game and search for criminals. At airports, they help identify explosives and illicit drugs. In disaster situations, they can rescue survivors and find human remains.

But each dog can only be trained to detect one class of odor compounds, which limits the range of smells it’s able to detect. Training costs tens of thousands of dollars and takes several months. For Florida startup Canaery, the solution is merging canines with neurotechnology to allow them to detect everything from bombs and other contraband to human diseases and environmental toxins—no specialized training needed.

Gene-edited rice can produce a compound that’s vital for human health

A team of Chinese scientists has used targeted gene editing to develop rice that produces coenzyme Q10 (CoQ10), a vital compound for human health.

Led by Prof. Chen Xiaoya from the CAS Center for Excellence in Molecular Plant Sciences/Shanghai Chenshan Research Center and Prof. Gao Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS), the researchers used targeted gene editing to modify just five amino acids of the Coq1 rice enzyme, creating new rice varieties capable of synthesizing CoQ10.

The study is published in Cell.

Muscle tissue meets mechanics in biohybrid hand breakthrough

Combining lab-grown muscle tissue with a series of flexible mechanical joints has led to the development of an artificial hand that can grip and make gestures. The breakthrough shows the way forward for a new kind of robotics with a range of potential applications.

While we’ve seen plenty of soft robots at New Atlas and a truly inspiring range of mechanical prosthetics, we’ve yet to see too many inventions that quite literally combine human tissue with machines. That’s likely because the world of biohybrid science is still in its very early stages. Sure, there was an artificial fish powered by human heart cells and a robot that used a locust’s ear to hear, but in terms of the practical use of the technology, the field has remained somewhat empty.

Now though, researchers at the University of Tokyo and Waseda University in Japan have shown a breakthrough demonstrating the real promise of the technology.

Light-activated Ink Developed to Remotely Control Cardiac Tissue to Repair the Heart

Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue. Their goal is to develop a technique that can be used to repair the heart. Their findings in preclinical models, published in Science Advances, show the transformative potential of non-invasive therapeutic methods to control electrically active tissues.

“We showed for the first time that with this optoelectronically active ink, we can print scaffolds that allow remote control of engineered heart tissues,” said co-corresponding author Y. Shrike Zhang, Ph.D., of the Division of Engineering in Medicine at Brigham and Women’s Hospital, a founding member of the Mass General Brigham health care system. “This approach paves the way for non-invasive light stimulation, tissue regeneration, and host integration capabilities in cardiac therapy and beyond.”

Three-dimensional bioprinted tissues composed of cells and other body-compatible materials are a powerful emerging tool to repair damaged heart tissue. But most bioprinted tissues cannot generate the necessary electrical activity for cellular function. They must instead rely on invasive wire and electrode placement to control heart activity, which can damage body tissues.