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Gene therapy was used to increase levels of Klotho, one of the first longevity genes discovered in the 1990’s, in mice. This led to improved physical fitness, muscular regenerative capacity, bone micrstructure, neurogenesis and a 20% increase in lifespan.
Contents:
Intro 0:00
Figure 1 — Longevity experiment follow-up and AAV treatment effectivity assessment 1:20
Figure 2 — Physical tests and histological analysis of muscular tissue from treated naturally aged animals 4:04
Figure 3 — Histological analysis of muscle from s-KL-treated animals 7 days after transplantation 6:27
Figure 4 — MicroCT structural and gene expression analysis in treated bones of 24-MO mice 7:34
Figure 5 — Histological analysis of Iba1, GFAP, and neurogenesis markers in CNS from aged animals 8:52
Figure 6 — Transcriptomic analysis of hippocampal RNA-seq data 9:59
Graphical Abstract & Conclusion 11:04.
Study reviewed:
Long-term effects of s-KL treatment in wild-type mice: Enhancing longevity, physical well-being, and neurological resilience.
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