Lifeboat Foundation: Safeguarding Humanity
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Category: biotech/medical – Page 215

Chromosomes are threadlike structures composed entirely of DNA that reside in the cells of all living things. Each one of these biological databanks contains a wealth of genetic information that scientists can use to glean insights into the history and evolution of life on Earth. Normally, the remains of dead creatures degrade over time, causing DNA to fragment. Most ancient animal DNA discovered to date has been incomplete, often comprised of fewer than 100 base pairs out of the billions that once made up the full sequence of the organism.

However, the 52,000-year-old skin sample at the heart of this research was taken from behind the ear of a mammoth discovered in Northern Siberia in 2018. An intensive analysis of the sample revealed the presence of complete fossil chromosomes. These chromosomes, each measuring billionths of a meter in length, had seemingly been frozen in a glass-like state for tens of thousands of years. Knowing the shape of an organism’s chromosomes can help researchers to assemble entire DNA sequences of extinct creatures, a task previously deemed nearly impossible due to DNA degradation over time.

“This is a new type of fossil, and its scale dwarfs that of individual ancient DNA fragments — a million times more sequence,” explained Erez Lieberman Aiden, a corresponding author on the study and director of the Center for Genome Architecture at the Baylor College of Medicine.

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(THE CONVERSATION) Racism steals time from people’s lives – possibly because of the space it occupies in the mind.

Question Is racial discrimination associated with brain connectivity, and are alterations in deep brain functional connectivity associated with accelerated epigenetic aging?

Findings In this cohort study of 90 Black women in the US, higher self-reported racial discrimination was associated with greater resting-state functional connectivity (RSFC) between the locus coeruleus (LC) and precuneus. Significant indirect effects were observed for the association between racial discrimination frequency and DNA methylation age acceleration.

Meaning These findings suggest that racial discrimination is associated with greater connectivity in pathways involved with rumination, which may increase vulnerability to stress-related disorders and neurodegenerative disease via epigenetic age acceleration.

Continue reading “Racial Discrimination, Neural Connectivity, and Epigenetic Aging in Black Women” | >

A Perseid is one whose path, if traced backward across the sky, intersects a spot between the constellations Perseus and Cassiopeia. Other “sporadic” meteors traveling in random directions occur once every 5 or 10 minutes. Two much weaker showers are also active at this time of the year, the Delta Aquarids and Kappa Cygnids.

You’ll need no experience to watch the Perseids. Just find a spot with a wide-open sky view and no late-night lights nearby. Bundle up warmly (it can sometimes get chilly even on summer nights), lie back on a ground pad or in a sleeping bag or even better, on a reclining lawn chair, and watch the stars. Also cover exposed parts of your body with mosquito repellent so you won’t get bit.

Be patient, and give your eyes sufficient time to dark adapt. The direction to watch is not necessarily toward Perseus but wherever your sky is darkest, probably straight up.

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Researchers at the University of California, Davis have developed a rapid, noninvasive tool to track the neurons and biomolecules activated in the brain by psychedelic drugs. The protein-based tool, which is called Ca2+-activated Split-TurboID, or CaST, is described in research published in Nature Methods.

There has been mounting interest in the value of psychedelic-inspired compounds as treatments for brain disorders including depression, and . Psychedelic compounds like LSD, DMT and psilocybin promote the growth and strengthening of neurons and their connections in the brain’s prefrontal cortex. The new tool could help scientists unlock the benefits of psychedelic treatments for patients with brain disorders.

“It’s important to think about the that these psychedelics act upon,” said Christina Kim, an assistant professor of neurology at the UC Davis Center for Neuroscience and School of Medicine, and an affiliate of the UC Davis Institute for Psychedelics and Neurotherapeutics. “What are they? Once we know that, we can design different variants that target the same mechanism but with fewer side effects.”

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Sorry, lol, i had to.

‘I’m never going to age’

It’s a crucial support to most everything our body does. When we’re young, our body is efficient at producing NAD.

As people age, production slowly tapers — which studies suggest might be one of the reasons we tend to feel worse as we get older.

Continue reading “Forget Ozempic. Celebrities are all in on taking a new anti-aging drug” | >

PROVO — A new study from a BYU professor is giving insights into the quality of popularly consumed carbohydrates in the U.S. with a new glycemic index and database developed with the use of artificial intelligence.

Nutrition and dietetics professor Karen Della Corte developed a national glycemic index and glycemic load database that was published in the American Journal of Clinical Nutrition. A news release from BYU said the data offers insights into the “evolving quality of carbohydrates consumed in the United States, something that hadn’t been done previously.”

She hopes this database helps increase awareness on the importance of carbohydrate quality in one’s diet and how, with other lifestyle factors, it can help prevent diseases and extend an individual’s health span.

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A group of scientists has devised a plan to safeguard Earth’s species in a cryogenic biorepository on the moon.

Intended to save species in the event of a disaster on Earth, the plan makes use of craters that are permanently in shadow and therefore cold enough to allow cryogenic preservation of biological material without using electricity or liquid nitrogen, according to research from a group led by scientists at the Smithsonian, published last week.

The paper, published in the journal BioScience, draws on the successful cryopreservation of skin samples from a fish, and outlines a method for creating a biorepository that would keep samples of other species safe.

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