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Incyte, Genesis Therapeutics Partner on AI-Based Small Molecule Collaboration

Incyte will partner with Genesis Therapeutics to research, discover, and develop small molecule treatments through a collaboration that could generate at least up to $620 million for Genesis, an artificial intelligence (AI)-based drug developer.

The companies have agreed to discover and optimize at least two initial small molecule programs through Genesis’s AI platform, Genesis Exploration of Molecular Space (GEMS). GEMS is designed to generate and optimize molecules for complex targets by integrating proprietary AI methods that include language models, diffusion models, and physical machine learning (ML) simulations.

Incyte has been granted exclusive rights for potential clinical development and commercialization of the products to be developed through the collaboration.

Can You Hear a Virus? Scientists Use Light To Listen to the Sounds of Life

Elad Harel is used to shining a light on the mysteries of the natural world.

Working at the cutting edge of ultrafast spectroscopy—the use of short laser pulses to analyze molecular dynamics—the Michigan State University associate professor seeks to uncover how microscopic phenomena impact large complex systems.

One promising frontier Harel has been working on is the development of new methods of microscopy that will allow researchers to observe molecular and atomic landscapes in motion rather than through static imagery. Such work has earned Harel MSU’s 2023 Innovation of the Year award, as well as MSU’s first-ever grant from the W.M. Keck Foundation.

What would happen if a (small) black hole passed through your body?

Imagine a supervillain attacking you with his unique superpower of creating small black holes. An invisible force zips through your body at unimaginable speed. You feel no push, no heat, yet, deep inside your body, atoms momentarily shift in response to the gravitational pull of something tiny yet immensely dense — a primordial black hole (PBH).

What would this do to you? Would it cause minor, localized damage, or would it simply rip through your entire body? Physicist Robert J. Scherrer from Vanderbilt University investigated this very scenario. His study examines what happens when a tiny black hole, like the ones formed in the early universe, passes through the human body.

The question is, of course, theoretical; but it does start from a realistic scenario. Unlike regular black holes that form when massive stars collapse, primordial black holes are thought to have emerged in the first fractions of a second after the Big Bang. While “regular” black holes typically weigh millions or billions of times more than the Sun, these PBHs could be incredibly small, with masses ranging from tiny asteroids to planets.

Scientists Uncover a Tiny Gene That Could End Dangerous Heart Arrhythmias

The key breakthrough? Finding a gene small enough to fit inside a viral delivery system. Early results in lab models suggest this therapy could be a game-changer, but further research is needed before it reaches clinical trials.

The Urgent Need for Better Arrhythmia Treatments

Cardiac arrhythmias affect millions worldwide and contribute to one in five deaths in the Netherlands. Current treatment options range from lifelong medication to invasive surgeries. However, new research from Amsterdam UMC and Johns Hopkins University, published today (February 20) in the European Heart Journal, marks a significant step toward a potential one-time gene therapy that could enhance heart function and prevent arrhythmias.

Deep Nanometry: Deep learning system detects disease-related nanoparticles

Researchers, including those from the University of Tokyo, developed Deep Nanometry, an analytical technique combining advanced optical equipment with a noise removal algorithm based on unsupervised deep learning.

Deep Nanometry can analyze nanoparticles in medical samples at high speed, making it possible to accurately detect even trace amounts of rare particles. This has proven its potential for detecting indicating early signs of colon cancer, and it is hoped that it can be applied to other medical and industrial fields.

The body is full of smaller than cells. These include extracellular vesicles (EVs), which can be useful in early disease detection and also in drug delivery.

Generative AI tool marks a milestone in biology

Imagine being able to speed up evolution – hypothetically – to learn which genes might have a harmful or beneficial effect on human health. Imagine, further, being able to rapidly generate new genetic sequences that could help cure disease or solve environmental challenges.

Now, scientists have developed a generative AI tool that can predict the form and function of proteins coded in the DNA of all domains of life, identify molecules that could be useful for bioengineering and medicine, and allow labs to run dozens of other standard experiments with a virtual query – in minutes or hours instead of years (or millennia).


Trained on a dataset that includes all known living species – and a few extinct ones – Evo 2 can predict the form and function of proteins in the DNA of all domains of life.

Telomeres Lengthened by 47% & Continue to Grow with Gene Therapy

Interesting item on biological clocks, and other things.


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Here Liz talks about her personal experience with gene therapy and the innovations, the state of the industry and what the future holds. The therapies exist why is it so difficult to make them available!?
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Akkermansia https://pendulumtherapeutics.sjv.io/b… Daily https://pendulumtherapeutics.sjv.io/N… OmegaQuant 5% discount Code MODERN https://omegaquant.com/shop/ Bulletproof 15% off with coupon code: HEALTHSPAN15: https://tinyurl.com/4npjk5vp Inner Fuel Gut support https://bulletproof.fdf2.net/PyDKDM Omega-3 Krill Oil https://bulletproof.fdf2.net/xkdxmy OneSkin 15% Discount: Code MODERN https://tinyurl.com/3t6tevj8 OS-01 Face Topical Supplement https://tinyurl.com/29c8wrr2 ⏲️Chapters 00:00 Liz’s interventions 12:40 Biological age tests and meaning 19:39 The paradigm of disease 23:30 Telomere results 26:00 Has she tried other therapies 30:20 Getting gene therapy now 40:50 Investment in longevity 47:10 CMV 50:40 Archie’s requirement for gene therapy 54:00 What is the future of BioViva & Gene therapy 1:01:00 Further information 🌐Links in this video BioViva Home Page https://bioviva-science.com/ BioViva on LinkedIn / biovivasciences Liz on X https://twitter.com/parrishliz BioViva on X https://twitter.com/BioVivaScience *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to [email protected]. ************************************************** #Lizparrish #genetherapy #telomeres.
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⏲️Chapters.
00:00 Liz’s interventions.
12:40 Biological age tests and meaning.
19:39 The paradigm of disease.
23:30 Telomere results.
26:00 Has she tried other therapies.
30:20 Getting gene therapy now.
40:50 Investment in longevity.
47:10 CMV
50:40 Archie’s requirement for gene therapy.
54:00 What is the future of BioViva & Gene therapy.
1:01:00 Further information.

🌐Links in this video.

China: World-first dual-loop brain-computer interface unveiled

The US, Europe, and China have all contributed significantly to BCI advancements. Companies like Elon Musk’s Neuralink focus on invasive brain implants, whereas Chinese researchers have made major strides in developing non-invasive and adaptive BCIs.

This latest breakthrough underscores China’s commitment to making BCIs more efficient and user-friendly. By enabling a two-way interaction between brain and machine, the new system takes a significant step toward integrating BCIs into everyday life, from medical rehabilitation to consumer electronics.

The study was published in the journal Nature Electronics.