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Category: biotech/medical – Page 219

3D nanoprinting technique can transform ceramics for high-performance systems, from disease detection to space travel

The same material from which you drink your morning coffee could transform the way scientists detect disease, purify water, and insulate space shuttles thanks to an entirely new approach to ceramic manufacturing.

Published in Advanced Science, 3D-AJP is an aerosol jet 3D nanoprinting technique that allows for the fabrication of highly complex ceramic structures that—at just 10 micrometers (a fraction of the width of human hair)—are barely visible to the naked eye. These 3D structures are made up of microscale features including pillars, spirals, and lattices that allow for controlled porosity, ultimately enabling advances in ceramic applications.

“It would be impossible to machine ceramic structures as small and as precise as these using traditional manufacturing methods,” explained Rahul Panat, professor of mechanical engineering at Carnegie Mellon University and the lead author of the study. “They would shatter.”

Scientists Identify Cellular “Switch” That May Reverse Diabetes

Mitochondrial stress disrupts insulinInsulin is a hormone produced by the pancreas, crucial for regulating blood glucose levels. It helps cells in the body absorb glucose from the bloodstream and convert it into energy or store it for future use. Insulin production and action are essential for maintaining stable blood sugar levels. In people with diabetes, the body either does not produce enough insulin (Type 1 diabetes) or cannot effectively use the insulin it does produce (Type 2 diabetes), leading to elevated levels of glucose in the blood. This can cause various health complications over time, including heart disease, kidney damage, and nerve dysfunction. Insulin therapy, where insulin is administered through injections or an insulin pump, is a common treatment for managing diabetes, particularly Type 1. The discovery of insulin in 1921 by Frederick Banting and Charles Best was a landmark in medical science, transforming diabetes from a fatal disease to a manageable condition. tabindex=0 insulin production in diabetes, but reversing the damage may restore β-cell function.

Potential autism breakthrough as three-year-old boy’s symptoms are reversed using cheap drug

A nonverbal autistic child said his first words after taking a cheap drug normally given to cancer patients.

Mason Conner of Arizona was diagnosed with autism at two-and-a-half-years-old after his mother noticed he hadn’t started talking.

After years of failed therapies and treatments, Mason’s parents met with a doctor researching experimental new therapies for autism.

UChicago Medicine offering breakthrough treatment for cancer patients

It’s a breakthrough in cancer treatment, and UChicago Medicine is one of the first hospitals to offer it.

It’s not just one treatment, but can eventually become a whole new way to treat cancer.

Alla Pinzour has been fighting skin cancer for around 15 years—but not anymore.

Gold nanodots can help boost cancer cell response to ultrasound treatment

Cells have surface receptors called integrins that bind to repetitive domains present on the extracellular matrix (ECM) surrounding the cells, allowing them to grow and spread. A new study from the Department of Bioengineering (BE), Indian Institute of Science (IISc) and collaborators shows that tweaking the spacing between these binding domains on the ECM can boost the efficiency of ultrasound treatment applied to kill cancer cells.

“In a normal tissue, the spacing on the ECM is around 50–70 nanometers (nm), but in the , severe choking occurs due to excessive ECM secretion, which may reduce the binding spacing to below 50 nm,” explains Ajay Tijore, Assistant Professor in BE and corresponding author of a related study published in Nano Letters. “We found more being killed when the binding spacing is increased to around 50–70 nm.”

Low-frequency ultrasound waves (39 kHz) can disrupt the and trigger cell death in cancer cells. It is a relatively low-cost and non-invasive approach. Unlike normal cells, cancer cells do not have repair mechanisms that help them withstand the exerted by ultrasound waves.

NanoCas, a smaller version of CRISPR tested with a single AAV, delivers on-target results

Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform gene editing in non-liver tissues, including skeletal muscle, using a single adeno-associated virus (AAV) vector. Experiments in non-human primates (NHPs) resulted in editing efficiencies exceeding 30% in muscle tissues.

CRISPR gene editing has revolutionized genetics, but delivery challenges have restricted its clinical applications primarily to ex vivo and liver-directed therapies. Conventional CRISPR nucleases, including Cas9 and Cas12a, exceed the packaging limits of a single AAV vector, necessitating dual-AAV strategies that reduce efficiency.

Smaller CRISPR systems such as Cas12i and CasX have been identified, but they remain too large or exhibit low editing efficiency. Existing compact systems like Cas14 and IscB have not demonstrated robust efficacy in large animal models.

Expanded understanding of how antibodies fight canine parvovirus may yield better vaccines

In 1978, parvovirus—then common to cats—started infecting dogs in Europe. The virus spread quickly around the globe, killing hundreds of thousands of dogs, mostly puppies—until a team of Cornell researchers led by the late Leland “Skip” Carmichael developed a vaccine, the derivatives of which are still used today.

“It was really at the time a worldwide relief, a miracle,” said Colin Parrish, interim director of the Baker Institute for Animal Health, who joined Carmichael’s lab as a graduate student in 1980 and is now senior author of a new study that continues to advance our understandings of the virus and how the vaccine works.

The paper, published Feb. 14 in Proceedings of the National Academy of Sciences, shows how host antibodies bind to parvovirus and neutralize it. The findings shed light on fundamental interactions between viruses and their hosts, and open new doors for improving current vaccines and treatments for infected animals.

Lethal second-generation rat poisons are killing endangered quolls and Tasmanian devils

Humans have been poisoning rodents for centuries. But fast-breeding rats and mice have evolved resistance to earlier poisons. In response, manufacturers have produced second generation anticoagulant rodenticides such as bromadiolone, widely used in Australian households.

Unfortunately, these potent poisons do not magically disappear after the is dead. For example, it’s well known who eat poisoned rodents suffer the same slow death from .

Our new research, published in the journal Science of The Total Environment, shows the problem is much bigger than owls. We found Australia’s five largest marsupial predators—the four quoll species and the Tasmanian devil—are getting hit by these poisons too.

Researchers spin ‘wheel of fortune’ to find a fundamental proof of quantum mechanics

Researchers from the National University of Singapore (NUS) and University of New South Wales (UNSW) Sydney have proven that a spinning atomic nucleus really is fundamentally a quantum resource. The teams were led respectively by Professor Valerio Scarani, from NUS Department of Physics, and Scientia Professor Andrea Morello from UNSW Engineering. The paper was published in the journal Newton on 14 February 2025.

It has long been inferred that tiny particles such as electrons or protons are indeed quantum due to the way they get deflected in a magnetic field. However, when left to spin freely, they appear to behave in exactly the same way as a classical spinning item, such as a Wheel of Fortune turning on its axis. For more than half a century, experts in spin resonance have taken this fact as a universal truth.

For the same reason, a technician or a doctor operating a (MRI) machine at the hospital never needed to understand quantum mechanics—the spinning of the protons inside the patient’s body produces the same kind of magnetic field that would be created by attaching a fridge magnet to a spinning wheel.