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Atsena raises $150M for ocular gene therapies with Bain, Sofinnova in tow

Atsena Therapeutics has raised $150 million in an oversubscribed series C financing, with hopes that the funds can carry the biotech’s gene therapy designed to reverse or prevent blindness through a potential market approval.

The funding round was led by new investor Bain Capital, with participation from Sofinnova Investments, Abingworth, Wellington Management, Lightstone Ventures, Foundation Fighting Blindness, Hatteras Venture Partners, Osage University Partners and the Manning Family Foundation, according to an April 2 release.

30 Years Younger & Telomere Extension? Could Short Chains of Amino Acids Revolutionize Anti-aging?

Could Short Chains of Amino Acids Revolutionize Anti-aging? We explore the exciting potential of peptide therapy to address key hallmarks of aging, including biological age and telomere length. This video delves into the science behind peptides and examines early clinical findings that suggest significant possibilities for age reversal.

What you’ll learn:
• Key peptides being studied for anti-aging (Epitalon, GHK-Cu, etc.).
• A look at clinical studies and patient data.
• The future of peptide therapy in longevity research.

Credits to : glycanage, dr. luis martinez of clinical peptide society

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Cancer cells ‘hacked’ to expose themselves to immune attack

When your social media account starts spewing out nonsensical or threatening status updates, it’s safe to assume that it has been hacked and must be shut down.

The cells in our body also update their “status” by presenting to their environment small proteins that are constantly being produced inside the cell. Our monitors these statuses and destroys cells that produce unusual proteins. A classic example of this is when a cell is infected by a virus and presents parts of the viral proteins on its surface, which allows the immune system to recognize them and destroy the cell.

In contrast, cancer cells often evade detection by displaying very few suspicious proteins that the immune system can identify and target. A new approach to cancer treatment, developed by researchers from Prof. Yardena Samuels’s lab at the Weizmann Institute of Science, increases the number of the immune system’s targets by disrupting production in .

Live-cell labeling sheds light on how our DNA is packed and behaves in cells

A team led by Professor Kazuhiro Maeshima of the National Institute of Genetics (ROIS) and SOKENDAI in Japan has developed a method to visualize different types of chromatin and reveal their distinct physical properties. They published their approach and findings on March 28 in Science Advances.

Inside every human cell, 2 meters of DNA must be tightly packed into a tiny nucleus. This DNA is wrapped around proteins to form chromatin, which exists in two main forms: euchromatin, where genes are active, and heterochromatin, where is suppressed.

“How these two types of chromatin are organized and behave inside living cells is still not well understood,” says Katsuhiko Minami, the first author of this study. “Until now, we lacked a way to specifically label euchromatin and heterochromatin in .”

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