David Sinclair shares another side of himself. Compassion for all people. He wants to make sure that longevity technologies are available for all people, not just for the super wealthy and their pets. He also speaks of emerging elderly populations who can live well up until death rather than suffering for so long, and instead start new careers and hobbies.
Researchers have restored vision in animal by resetting some of the thousands of chemical marks that accumulate on DNA as cells age. The work, by Dr David Sinclair Lab, published in Nature Dec 2020, suggests a new approach to reversing age-related decline, by reprogramming some cells to a ‘younger’ state in which they are better able to repair or replace damaged tissue.
David A. Sinclair, Ph.D. A.O. is a tenured Professor in the Genetics Department at the Blavatnik Institute, Harvard Medical School, Boston & Co-Director of the Paul F. Glenn Center for Biology of Aging Research, honorary Professor at the University of Sydney, and co-founder of the journal Aging. He obtained a BS and a Ph.D. at UNSW, worked as a postdoctoral researcher at M.I.T., was hired at Harvard Medical School in 1999 as an Assistant Professor, and promoted to tenured Professor in 2008. His book Lifespan: Why We Age and Why We Don’t Have To, a NYT bestseller, is published in more than 20 languages.
Dr. Sinclair is an inventor on more than 50 patents, 170 papers, an h-index of 103 & cited 73,000+ times. His more than 40 awards include an Excellence in Teaching Award, Harvard, AFAR Fellowship, the Ellison Medical Foundation Scholarships, Genzyme Outstanding Achievement Award, Telluride Technology Award, Innovator of the Year, MERIT Award, Nathan Shock Award, Denham Harman Award, ASMR Medal, Advance Global Australian, Pioneer Award, TIME100’s most influential people, TIME magazine’s Heathcare 50, Irving Wright Award, AFAR, and is an Officer of the Order of Australia (AO).
He cofounded Sirtris Pharma (Cambridge; NASDAQ: SIRT, bought by GSK), Genocea (Cambridge, MA; NASDAQ: GNCA); Ovascience (NASDAQ: OVAS), Cohbar (Menlo Park NASDAQ: CWBR)), MetroBiotech, ArcBio, Liberty Biosecurity, Galilei, Immetas, EdenRoc Sciences and affiliates, and Life Biosciences and affiliates.
The application of mechanic forces to the cell nucleus affects the transport of proteins through the nuclear membrane, an action that controls cellular processes and could play a key role in several diseases such as cancer. These findings draw a new scenario for understanding how the mechanic forces drive the progression of cancer and open the doors to the design of potential innovative techniques—both diagnostic and therapeutic. This is the conclusion of a study published in the journal Nature Cell Biology led by lecturer Pere Roca-Cusachs, from the Faculty of Medicine and Health Sciences of the University of Barcelona, the Institute of Nanoscience and Nanotechnology of the UB (IN2UB) and the Institute for Bioengineering of Catalonia (IBEC).
The cells in the body receive mechanical stimuli from their environment and respond accordingly regarding decisions on how and when to grow, move and differentiate. The process is known as mechanotransduction and it is critically important for the cell function and for human health.
The study reveals that the direct application of force to the nucleus can affect the spatial organization of the DNA and the activity of nuclear proteins, among other functions. When cancer cells invade the organs and metastasis appears, these create physical forces that are transmitted to the cell nucleus.
Holes help make sponges and English muffins useful (and, in the case of the latter, delicious). Without holes, they wouldn’t be flexible enough to bend into small crevices, or to sop up the perfect amount of jam and butter.
In a new study, University of Chicago scientists find that holes can also improve technology, including medical devices. Published in Nature Materials, the paper describes an entirely new way to make a solar cell: by etching holes in the top layer to make it porous. The innovation could form the basis for a less-invasive pacemaker, or similar medical devices. It could be paired with a small light source to reduce the size of the bulky batteries that are currently implanted along with today’s pacemakers.
“We hope this opens many possibilities for further improvements in this field,” said Aleksander Prominski, the first author on the paper.
A major campaign of domino-toppling simulations yields new insights into the effects of friction.
Despite the apparent simplicity of toppling dominoes, physicists still don’t have a complete model of the phenomenon. But new numerical simulations get a step closer by untangling the influence of two types of friction—one between neighboring dominoes and the other between each domino and the surface beneath it [1]. The researchers found that, in some cases, these two friction coefficients play competing roles in determining the speed of the domino cascade. They also found that one of the coefficients behaves similar to friction in granular systems such as piles of sand or pharmaceutical pills, suggesting that the domino simulations may provide insights into other situations where friction is important.
A YouTube video by engineer Destin Sandlin (on his channel Smarter Every Day) inspired David Cantor of Montreal Polytechnic and Kajetan Wojtacki of the Polish Academy of Sciences in Warsaw to study dominoes. Sandlin recorded a series of domino toppling experiments with a high-speed camera and quickly discovered just how complex the problem is. He determined that the wave of falling dominoes moves slightly faster on felt than on a slippery hardwood floor. He also saw surprising anomalies, such as cases where the train of toppling dominoes would abruptly stop.
No one should think we are over COVID.
WASHINGTON — Federal health officials warned on Wednesday that a third of Americans live in areas where the threat of Covid-19 is now so high that they should consider wearing a mask in indoor public settings. They cited new data showing a substantial jump in both the spread of the coronavirus and hospitalizations over the past week.
Dr. Rochelle P. Walensky, the director of the Centers for Disease Control and Prevention, said that the seven-day average of hospital admissions from Covid rose 19 percent over the previous week. About 3,000 people a day were being admitted with Covid, she said, although death rates, a lagging indicator, remained low.
More than 32 percent of Americans now live in counties with medium to high levels of virus transmission, compared with about 24 percent the previous week. Dr. Walensky said that local leaders and individuals in those regions should adopt — or at least consider — prevention strategies, such as masking in indoor public settings and more frequent testing.
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Papers referenced in the video:
Glycine supplementation extends lifespan of male and female mice.
https://pubmed.ncbi.nlm.nih.gov/30916479/
Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation.
https://pubmed.ncbi.nlm.nih.gov/34877949/
17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex.
https://pubmed.ncbi.nlm.nih.gov/33788371/
Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors.