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Probiotic Bacteria: A Promising Tool in Cancer Prevention and Therapy

Probiotics show a new to battle cancer and other diseases keeping the host body healthy with its anti inflammation abilities.

Gut microbiota is widely considered to be one of the most important components to maintain balanced homeostasis. Looking forward, probiotic bacteria have been shown to play a significant role in immunomodulation and display antitumour properties. Bacterial strains could be responsible for detection and degradation of potential carcinogens and production of short-chain fatty acids, which affect cell death and proliferation and are known as signaling molecules in the immune system. Lactic acid bacteria present in the gut has been shown to have a role in regression of carcinogenesis due to their influence on immunomodulation, which can stand as a proof of interaction between bacterial metabolites and immune and epithelial cells. Probiotic bacteria have the ability to both increase and decrease the production of anti-inflammatory cytokines which play an important role in prevention of carcinogenesis. They are also capable of activating phagocytes in order to eliminate early-stage cancer cells. Application of heat-killed probiotic bacteria coupled with radiation had a positive influence on enhancing immunological recognition of cancer cells. In the absence of active microbiota, murine immunity to carcinogens has been decreased. There are numerous cohort studies showing the correlation between ingestion of dairy products and the risk of colon and colorectal cancer. An idea of using probiotic bacteria as vectors to administer drugs has emerged lately as several papers presenting successful results have been revealed. Within the next few years, probiotic bacteria as well as gut microbiota are likely to become an important component in cancer prevention and treatment.

Cancer is considered as one of the most significant causes of death. The treatment of tumors has received much attention in the last years; however, the number of people suffering neoplastic syndrome is still increasing. Thus, researchers are trying to face this process searching for innovative therapies and prophylaxis. Despite the fact that cancer risk indisputably depends on genetic factors, immunological condition of the organism plays a considerable role in it, that being closely associated with probiotic bacteria and commensal bacterial flora presented mainly in the digestive tract. Probiotic strains, inter alia Bifidobacterium, or Lactobacillus, widely present in commonly consumed fermented milk products, are known to have various beneficial effects on health. To date, there is a plethora of studies investigating the correlation between intestinal microbiota and carcinogenesis which have been evaluated in this article.

Scientists Claim to Improve Human Brain Function With Implants and AI

“The analogy I often use is an electric bike,” he added. “When someone’s pedaling but having difficulty, the bike senses it and augments it. We’ve made the equivalent of that for human mental function.”

Participants in the trial reported that their anxiety got better once the system jumped into action, mostly due to the fact that they had more cognitive control and were able to shift their focus better.

“This could be a totally new approach in treating mental illness,” Widge said. “Instead of trying to suppress symptoms, we could give patients a tool that lets them take control of their own minds.”

Blood Pressure E-Tattoo Promises Continuous, Mobile Monitoring

Blood pressure is one of the most important indicators of heart health, but it’s tough to frequently and reliably measure outside of a clinical setting. For decades, cuff-based devices that constrict around the arm to give a reading have been the gold standard. But now, researchers at The University of Texas at Austin and Texas A&M University have developed an electronic tattoo that can be worn comfortably on the wrist for hours and deliver continuous blood pressure measurements at an accuracy level exceeding nearly all available options on the market today.

“Blood pressure is the most important vital sign you can measure, but the methods to do it outside of the clinic passively, without a cuff, are very limited,” said Deji Akinwande, a professor in the Department of Electrical and Computer Engineering at UT Austin and one of the co-leaders of the project, which is documented in a new paper published today in Nature Nanotechnology.

High blood pressure can lead to serious heart conditions if left untreated. It can be hard to capture with a traditional blood pressure check because that only measures a moment in time, a single data point.

Weirdly, It Appears the Flu Vaccine May Protect Against Alzheimer’s

In a surprise finding, researchers have found that getting at least one flu shot makes it 40 percent less likely for people over the age of 65 to be diagnosed with Alzheimer’s disease, up to four years later.

While it’s still far too early to determine if there are any direct causal links between the common vaccine and neurological health outcomes like Alzheimer’s — in other words, we don’t know if it’s the flu vaccine itself or something else responsible for the results — the research is certainly an eyebrow-raising new development that could, potentially, point in the direction of easily accessible treatments.

In a peer-reviewed study in the Journal of Alzheimer’s Disease, researchers at UTHealth Houston compared the incidence rate of the disease in patients with and without at least one flu vaccination in a nationwide sample of US adults aged 65 and up, which included 935,887 vaccinated and 935,887 non-vaccinated individuals.

Why People are Microchipping their Brains — Next-Gen BCI’s: Neurograins

Neurograins might be the future of implantable Brain Computer Interfaces due to their advantages in terms of abilities and safety in terms of implantation. Due to being the smallest Microchips ever made, in addition to being very powerful, they can make very high resolution recordings of brain activity and even stimulate areas in the brain for medical treatments for people suffering from brain disorders.

The field of neuroscience is developing at a rapid pace, which constantly improves on our BCI Technology and enabling more and more treatments and applications for Brain Computer Interface. It’s clear that this is very advanced future technology and who knows, maybe these new Neurograin Brain Computer Interfaces may play a part in it. Or maybe Elon Musk’s Neuralink’s approach will win in the end. People willingly microchipping their brains will be more common in the future.
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TIMESTAMPS:
00:00 The smallest Chips ever made?
01:48 How is it different?
02:47 How this Brain Computer Interface works.
03:51 What can this BCI do?
05:46 The Future of Brain Computer Interfaces.
08:30 Last Words.
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#Neurograins #bci #neuralink

New Drug Could Help Stop Depression, Anxiety, Brain Injury, and Cognitive Disorders

The preclinical drug works by inhibiting the kinase Cdk5 which is found in mature neurons. Cdk5 has long been linked to neuropsychiatric and neurodegenerative disorders, but prior inhibitors have largely failed to cross the blood-brain barrier and enter the brain.

A new preclinical drug reported by James Bibb, Ph.D., and colleagues has the potential to combat depression, brain injury, and cognitive disorders. The drug, which is notable for being brain-permeable, works by inhibiting the kinase enzyme Cdk5.

Cdk5 is an important signaling regulator in brain neurons. Over three decades of research, it has been linked to neuropsychiatric and degenerative disorders such as Alzheimer’s.

Toward Cardiac Regeneration: Combination of Pluripotent Stem Cell-Based Therapies and Bioengineering Strategies

Circa 2020 Immortality of the heart and heart regeneration.

Cardiovascular diseases represent the major cause of morbidity and mortality worldwide. Multiple studies have been conducted so far in order to develop treatments able to prevent the progression of these pathologies. Despite progress made in the last decade, current therapies are still hampered by poor translation into actual clinical applications. The major drawback of such strategies is represented by the limited regenerative capacity of the cardiac tissue. Indeed, after an ischaemic insult, the formation of fibrotic scar takes place, interfering with mechanical and electrical functions of the heart. Hence, the ability of the heart to recover after ischaemic injury depends on several molecular and cellular pathways, and the imbalance between them results into adverse remodeling, culminating in heart failure. In this complex scenario, a new chapter of regenerative medicine has been opened over the past 20 years with the discovery of induced pluripotent stem cells (iPSCs). These cells share the same characteristic of embryonic stem cells (ESCs), but are generated from patient-specific somatic cells, overcoming the ethical limitations related to ESC use and providing an autologous source of human cells. Similarly to ESCs, iPSCs are able to efficiently differentiate into cardiomyocytes (CMs), and thus hold a real regenerative potential for future clinical applications. However, cell-based therapies are subjected to poor grafting and may cause adverse effects in the failing heart. Thus, over the last years, bioengineering technologies focused their attention on the improvement of both survival and functionality of iPSC-derived CMs. The combination of these two fields of study has burst the development of cell-based three-dimensional (3D) structures and organoids which mimic, more realistically, the in vivo cell behavior. Toward the same path, the possibility to directly induce conversion of fibroblasts into CMs has recently emerged as a promising area for in situ cardiac regeneration. In this review we provide an up-to-date overview of the latest advancements in the application of pluripotent stem cells and tissue-engineering for therapeutically relevant cardiac regenerative approaches, aiming to highlight outcomes, limitations and future perspectives for their clinical translation.

Cardiovascular diseases represent the major cause of morbidity and mortality worldwide, accounting for 31% of all deaths (Organization WH 2016). Myocardial infarction (MI) is associated with necrosis of the cardiac tissue due to the occlusion of the coronary arteries, a condition that irrevocably diminishes oxygen and nutrient delivery to the heart (Thygesen et al., 2007). While effective therapies, including surgical approaches, are currently used to treat numerous cardiac disorders, such as valvular or artery diseases, available therapeutic treatments for the damaged myocardium are still very limited and poorly effective. Furthermore, after an ischaemic insult, the formation of fibrotic scar takes place, interfering with mechanical and electrical functions of the cardiac tissue (Talman and Ruskoaho, 2016).

Mitochondrial uncoupling attenuates sarcopenic obesity

Mitochondrial uncoupling by agents such as BAM15 may mitigate age-related decline in muscle mass and function by molecular and cellular bioenergetic adaptations that confer protection against sarcopenic obesity.

Background Sarcopenic obesity is a highly prevalent disease with poor survival and ineffective medical interventions. Mitochondrial dysfunction is purported to be central in the pathogenesis of sarcopenic obesity by impairing both organelle biogenesis and quality control. We have previously identified that a mitochondrial-targeted furazano[3,4-b]pyrazine named BAM15 is orally available and selectively lowers respiratory coupling efficiency and protects against diet-induced obesity in mice. Here, we tested the hypothesis that mitochondrial uncoupling simultaneously attenuates loss of muscle function and weight gain in a mouse model of sarcopenic obesity.

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