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Dr Katcher’s E5 Lifespan Experiment Final Result | 22% Lifespan Extension

So, 22% increase. Roughly like a 120 person, which means if this literally translates to people it means a maximizing of our current lifespan. The rest is just a rundown of Aubrey’s experiment.

Dr Katcher’s lifespan experiment has come to an end as the last remaining rat, Sima, has died. She was 1,464 days old which is a record for Sprague-Dawley rats. We also talk about the exciting Robust Mouse Rejuvenation project at the LEV Foundation.

Longevity Escape Velocity Foundation projects web page _https://www.levf.org/projects_

📃Papers in this video.
Reversing age: dual species measurement of epigenetic age with a single clock.
_https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full_

*Renue By Science* 10% : _https://tinyurl.com/4yrf4tv3_

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This insertable 3D printer will repair tissue damage from the inside

Researchers at the University of New South Wales, Sydney, have developed a flexible 3D bioprinter that can layer organic material directly onto organs or tissue. Unlike other bioprinting approaches, this system would only be minimally invasive, perhaps helping to avoid major surgeries or the removal of organs. It sounds like the future — at least in theory — but the research team warns it’s still five to seven years away from human testing.

The printer, dubbed F3DB, has a soft robotic arm that can assemble biomaterials with living cells onto damaged internal organs or tissues. Its snake-like flexible body would enter the body through the mouth or anus, with a pilot / surgeon guiding it toward the injured area using hand gestures. In addition, it has jets that can spray water onto the target area, and its printing nozzle can double as an electric scalpel. The team hopes its multifunctional approach could someday be an all-in-one tool (incising, cleaning and printing) for minimally invasive operations.

The F3DB’s robotic arm uses three soft-fabric-bellow actuators using a hydraulic system composed of “DC-motor-driven syringes that pump water to the actuators,” as summarized by IEEE Spectrum. Its arm and flexible printing head can each move in three degrees of freedom (DOFs), similar to desktop 3D printers. In addition, it includes a flexible miniature camera to let the operator view the task in real time.

Blood Test #2 in 2023: Impact of NMN?

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Study examines how our native language shapes our brain wiring

Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig have found evidence that the language we speak shapes the connectivity in our brains that may underlie the way we think. With the help of magnetic resonance tomography, they looked deep into the brains of native German and Arabic speakers and discovered differences in the wiring of the language regions in the brain.

Xuehu Wei, who is a doctoral student in the research team around Alfred Anwander and Angela Friederici, compared the of 94 of two very and showed that the language we grow up with modulates the wiring in the brain. Two groups of native speakers of German and Arabic respectively were scanned in a imaging (MRI) machine.

The high-resolution images not only show the anatomy of the brain, but also allow to derive the connectivity between the using a technique called diffusion-weighted imaging. The data showed that the axonal white matter connections of the language network adapt to the processing demands and difficulties of the mother tongue.

Scientists Identify New Schizophrenia Risk Genes in First-of-Its-Kind Study

Two newly discovered genes have been linked to schizophrenia while a previously known gene associated with schizophrenia risk has also been linked to autism in a massive new study.

Scientists say the findings increase our understanding of brain diseases and could lead to new treatment targets.

Importantly, this is the first known investigation to look at the risk of schizophrenia in different groups of people, especially those with African ancestry. It revealed rare harmful variations in gene proteins raise the risk of schizophrenia in all ethnic groups.

Four Walls Good, Two Walls Bad for Confined Cells

Segregation of chromosomes in dividing cells can be disrupted if the cells are constrained by their surroundings.

One of the aberrant features of cancer cells is a failure to distribute chromosomes properly when the cells divide. Researchers have now found that a specific problem with the chromosome-distribution machinery can become more common in cancer cells confined within shallow microscopic channels—but also that, surprisingly, increasing the physical constraints can suppress these errors [1]. Such confinement mimics the effects of crowding by surrounding cells in a tumor, and the researchers believe the results might help to explain what goes awry in cancers and perhaps offer clues to how it might be put right.

In a healthy, dividing cell, after the genome is replicated, the chromosomes are segregated into two groups. Both groups are bound to the mitotic spindle, a bundle of aligned filaments (called microtubules) that are pinched together at the ends into structures called poles. The chromosomes are then drawn along the microtubules toward the poles. A key cause of improper chromosome segregation in cancer cells is the formation of spindles with more than two poles. Multipolar spindle formation inside living organisms may differ from the phenomenon when observed in cells grown in a dish [2], so it is possible that the confining effect of the surrounding cells in a tissue has some influence on this process.