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Amino Acid Patterns Help Scientists Distinguish Alien Life

Dr. Fabian Klenner: “We’re showing that life does not only produce molecules. Life also produces an organizational principle that we can see by applying statistics.” [ https://www.labroots.com/trending/space/30534/amino-acid-pat…ien-life-2](https://www.labroots.com/trending/space/30534/amino-acid-pat…ien-life-2)

What methods can scientists use to correctly identify biosignatures, aka signs of life beyond Earth? This is what a recent study Nature Astronomy hopes to address as a team of researchers from the University of California, Riverside (UC Riverside) and Israel investigated a new pattern-based method for identifying biosignatures. This study has the potential to help scientists develop new methods for finding life beyond Earth, which could narrow the scope for both how and where to find life.

For the study, the researchers used mathematics to suggest that instead of looking for specific molecules when searching for biosignatures scientists should instead look for organizational patterns. The primary motivation behind the study was to challenge longstanding methods regarding how to search for biosignatures, which have traditionally been focused on finding individual and specific molecules. In the end, the researchers found that the amino acids in biological (biotic) samples exhibited a much larger range of diversity compared to non-biological (abiotic) samples. These could shape a new generation of astrobiology, which is the study of searching for life beyond Earth.

“We’re showing that life does not only produce molecules,” said Dr. Fabian Klenner, who is an assistant professor of planetary sciences at UC Riverside and a co-author on the study. “Life also produces an organizational principle that we can see by applying statistics.”

Venus Clouds Driven by Solar System’s Largest Waves

“Up until now, we used a global circulation model (GCM) for Venus that is similar to Earth’s, but this model doesn’t include the hydraulic jump which we have now identified,” said Dr. Takeshi Imamura. [ https://www.labroots.com/trending/space/30535/venus-clouds-d…gest-waves](https://www.labroots.com/trending/space/30535/venus-clouds-d…gest-waves)

What explains the unique behavior of Venus’ clouds? This is what a recent study published in the Journal of Geophysical Research: Planets hopes to address as an international team of scientists led by Japan and included the United States and Spain investigated a longstanding conundrum regarding Venus’ meteorology, specifically cloud weather patterns. This study has the potential to help scientists better understand planetary cloud patterns and what this can teach us about planetary formation and evolution.

For the study, the researchers used a series of computer models to simulate Venus’ cloud weather patterns, specifically focusing on a 6,000-kilometer-wide (3,728-mile-wide) cloud front whose behavior has puzzled scientists for years. The primary puzzlement is the origin of the massive cloud wave, which current global climate models can’t explain. Along with the puzzlement, the motivation behind the study also comes from a knowledge gap in the formation of the lower cloud regions within Venus’ atmosphere.

In the end, the researchers found that a phenomenon known as a “hydraulic jump” was responsible for producing the massive cloud wave front. This jump is caused by changes in airflow in the lower cloud regions combined with a strong updraft, resulting in sulfuric acid vapor (which comprises Venus’ clouds) to condense, forming the massive cloud wave front. This study helps explain the connection between the Venusian atmosphere motion and clouds.

Cost-Effectiveness of Thrombectomy With or Without Alteplase in Large Vessel Occlusion StrokeA Meta-Analysis Considering Time-to-Treatment

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A neuropeptide regulates cell non-autonomous protein homeostasis

FLP-17’s role in stress resistance aligns with its established functions. FLP-17 belongs to an evolutionarily conserved class, FMRF-amide/RF-amide neuropeptides, that plays important roles in energy balance and reproduction across phyla.34,35 In C. elegans, FLP-17 is secreted from a pair of sensory neurons (BAG) in response to low oxygen and high carbon dioxide, which can be caused by unfavorable food conditions or pathogens.36,37 FLP-17 then acts through specific neurons to inhibit egg laying and initiate an aversion behavior until the animal has reached more favorable conditions.30,36 Interestingly, unfavorable food conditions and pathogens also threaten organismal protein homeostasis.33,38 Therefore, we speculate that FLP-17 evolved to simultaneously protect the animal from proteotoxic stress while facilitating a behavioral program to help the animal navigate to more favorable conditions.

To coordinate adaptive behavioral and metabolic responses, FLP-17 primarily signals through the GPCR EGL-6 in specific neurons.30,31 Therefore, we tested whether EGL-6 also mediates FLP-17’s role in UPRER activation and found that FLP-17-induced activation of the UPRER and ER stress resistance is partially dependent on EGL-6. Egl-6 expression is predominantly neuronal, evidenced by transcriptional reporters and single-cell RNA-seq datasets.30,39 However, low levels of egl-6 expression were detected in intestine-specific translation of ribosome-affinity purification, which may better reflect protein levels.40 This suggests that FLP-17 may signal either through an intermediate cell type (such as a neuron) or directly to the intestine to activate UPRER.30,39 Furthermore, the partial dependence, combined with persistent stress gene activation in egl-6 (lof) backgrounds (Figure 5 E), indicates that additional unidentified receptors and mechanisms likely contribute to FLP-17 phenotypes.

Although FLP-17 was sufficient to activate the UPRER, it was not required for cell non-autonomous activation of the UPRER by glial:: xbp-1s, as flp-17 null mutants did not suppress glial:: xbp-1s phenotypes. This likely reflects neuropeptide network redundancy. Supporting this hypothesis, flp-17 (lof)) resulted in modest upregulation of stress response genes (Figure S3G) and a slight increase in hsp-4p::GFP in the glial:: xbp-1s animals (Figure 2D), suggesting compensatory activation of stress signaling pathways when FLP-17 is absent. This compensation could occur through multiple mechanisms. First, glial:: xbp-1s may induce multiple neuropeptides that provide functionally redundant UPRER activation. While no other candidate from our neuropeptidomics screen was individually sufficient to induce UPRER, we cannot exclude compensation by peptides not detected in our analysis, such as insulin-like peptides.

This Physicist (Unexpectedly) Derived Gravity from Information

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What if gravity is just entropy in disguise? Professor Erik Verlinde joins me to argue that gravity isn’t a fundamental force—it’s thermodynamic, emerging from quantum information the way gas pressure emerges from molecules bouncing around. We explore why spacetime may be stitched together by entanglement, and how dark energy and dark matter both pop out automatically without extra particles or parameters. Verlinde explains why the cosmological constant problem is a red herring, and why there may be no final theory of physics. When asked where the universe comes from, his answer is one word: chaos.

SUPPORT: Support me on Substack: https://curtjaimungal.substack.com/su… me on Crypto: https://commerce.coinbase.com/checkou… Support me on PayPal: https://www.paypal.com/donate?hosted_… JOIN MY SUBSTACK (Personal Writings): https://curtjaimungal.substack.com LISTEN ON SPOTIFY: https://open.spotify.com/show/4gL14b9… TIMESTAMPS:

  • 00:00:00 — Thermodynamic Gravity and Information
  • 00:06:35 — Beyond Effective Field Theory
  • 00:13:08 — Turtles All The Way Down
  • 00:25:41 — Entropy as a Force
  • 00:36:31 — Entanglement and Spatial Connectivity
  • 00:47:31 — Deriving Inertia and F=ma
  • 00:56:41 — De Sitter Space Challenges
  • 01:02:01 — Dark Matter and Milgram
  • 01:11:51 — The Emergence of Time
  • 01:21:01 — Statistical Gravity Fluctuations
  • 01:27:01 — Quantum Computational Complexity
  • 01:36:01 — Physics Intuition and Mentorship
  • 01:47:31 — Beauty, Garbage, and Chaos

LINKS MENTIONED: Papers, books, websites:

Videos:

  • • A 2 Hour Deep Dive into Entropy
  • • The Mathematics of String Theory [Graduate…
  • • The Debate That Divides Physics: Is the Un…
  • • The Physicist Who Found Quantum Theory’s U…
  • • Retrocausality & The Transactional Interpr…
  • • The Physicist Who Proved Entropy = Gravity
  • • The Physicist Who Says Time Doesn’t Exist
  • • The Most Astonishing Theory of Black Holes
  • • The (Simple) Theory That Explains Everythi…
  • • The Crisis in String Theory is Worse Than…
  • • Dark Dimensions: NEW THEORY Unifying Dark…
  • • MIT Scientist’s Discovery: “Black Holes Mi…
  • • The Woman Who Broke Gravity | Claudia de Rham
  • • Solving the Problem of Consciousness | Ste…
  • • Frederic Schuller: The Physicist Who Deriv…
  • • The Loop Quantum Gravity Debacle: Carlo Ro…
  • • An (Elementary) Introduction to Quantum Co…
  • • Can Physics Explain Its Own Laws?
  • • The Nobel Laureate Who (Also) Says Quantum…
  • • This Cosmologist Discovered Something Stra…
  • • Michael Levin: Consciousness, Biology, Uni…

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JOIN MY SUBSTACK (Personal Writings): https://curtjaimungal.substack.com.

LISTEN ON SPOTIFY: https://open.spotify.com/show/4gL14b9…

TIMESTAMPS: 00:00:00 — Thermodynamic Gravity and Information 00:06:35 — Beyond Effective Field Theory 00:13:08 — Turtles All The Way Down 00:25:41 — Entropy as a Force 00:36:31 — Entanglement and Spatial Connectivity 00:47:31 — Deriving Inertia and F=ma 00:56:41 — De Sitter Space Challenges 01:02:01 — Dark Matter and Milgram 01:11:51 — The Emergence of Time 01:21:01 — Statistical Gravity Fluctuations 01:27:01 — Quantum Computational Complexity 01:36:01 — Physics Intuition and Mentorship 01:47:31 — Beauty, Garbage, and Chaos.

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