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Leading The Next Wave Of Innovation In Drug Discovery, To Modulate Any Target, Every Time — Dr. P. Ryan Potts, Ph.D., VP and Head, Induced Proximity Platform, Amgen.

Dr. Ryan Potts, Ph.D. is Vice President and Head, Induced Proximity Platform at Amgen (https://www.amgen.com/science/researc…) which is focused on novel ways to bring two or more molecules in close proximity to each other to tackle drug targets that are currently considered “undruggable.” He also leads Amgen’s Research \& Development Postdoctoral Fellows Program (https://www.amgen.com/science/scienti…).

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Using supercomputers and satellite imagery, the researchers showed our planet breathing.

Single-photon detectors built from superconducting nanowires have become a vital tool for quantum information processing, while their superior speed and sensitivity have made them an appealing option for low-light imaging applications such as space exploration and biophotonics. However, it has proved difficult to build high-resolution cameras from these devices because the cryogenically cooled detectors must be connected to readout electronics operating at room temperature. Now a research team led by Karl Berggren at the Massachusetts Institute of Technology has demonstrated a superconducting electronics platform that can process the single-photon signals at ultracold temperatures, providing a scalable pathway for building megapixel imaging arrays [1].

The key problem with designing high-resolution cameras based on these superconducting detectors is that each of the sensors requires a dedicated readout wire to record the single-photon signals, which adds complexity and heat load to the cryogenic system. Researchers have explored various multiplexing techniques to reduce the number of connections to individual detectors, yielding imaging arrays in the kilopixel range, but further scaling will likely require a signal-processing solution that can operate at ultralow temperatures.

Berggren and his collaborators believe that the answer lies in devices called nanocryotrons (nTrons), which are three-terminal structures made from superconducting nanowires, just like the single-photon detectors are. Although nTrons do not deliver the same speed and power of superconducting electronics based on Josephson junctions, the researchers argue that these shortcomings are not a critical problem in photon-sensing applications, where the detectors are similarly limited in speed and power. The nTrons also offer several advantages over Josephson junctions: they operate over a wider range of cryogenic temperatures, they don’t require magnetic shielding, and they exploit the same fabrication process as that used for the detectors, allowing for easy on-chip integration.

Even today, centuries after he lived, Johann Sebastian Bach remains one of the world’s most popular composers. On Spotify, close to seven million people stream his music per month, and his listener count is higher than that of Mozart and even Beethoven. The Prélude to his Cello Suite No. 1 in G Major has been listened to hundreds of millions of times.

A crowd or a flock of birds have different characteristics from those of atoms in a material, but when it comes to collective movement, the differences matter less than we might think. We can try to predict the behavior of humans, birds, or cells based on the same principles we use for particles.

Researchers at TMOS, the ARC Center of Excellence for Transformative Meta-Optical Systems, and their collaborators at RMIT University have developed a new 2D quantum sensing chip using hexagonal boron nitride (hBN) that can simultaneously detect temperature anomalies and magnetic field in any direction in a new, groundbreaking thin-film format.

Mathematical solutions to thorny quantum problems can be found more quickly by exploiting the correspondence between the statistical methods used in deep learning and techniques for implementing quantum simulations, a team led by a RIKEN researcher has shown in a new study published in the Journal of High Energy Physics.

Future optical communication and signal processing systems will require high-volume optical links, wherein photonic integrated devices play a key role. Si photonics is currently among the most advanced techniques for realizing low-cost PIC. However, despite their enormous potential, there remain basic restraints on light modulation in SOI waveguides. The absence of a linear EO coefficient is challenging because of the crystal structure of Si.

Helical foldamers are a class of artificial molecules that fold into well-defined helical structures like helices found in proteins and nucleic acids. They have garnered considerable attention as stimuli-responsive switchable molecules, tuneable chiral materials, and cooperative supramolecular systems due to their chiral and conformational switching properties.

Double-helical foldamers exhibit not only even stronger chiral properties but also unique properties, such as the transcription of chiral information from one chiral strand to another without chiral properties, enabling potential applications in higher-order structural control related to replication, like nucleic acids.

However, the artificial control of the chiral switching properties of such artificial molecules remains challenging due to the difficulty in balancing the dynamic properties required for switching and stability. Although various helical molecules have been developed in the past, reversal of twist direction in double-helix molecules and supramolecules has rarely been reported.