Lifeboat Foundation

During aging, the human methylome undergoes both differential and variable shifts, accompanied by increased entropy. The distinction between variably methylated positions (VMPs) and differentially methylated positions (DMPs), their contribution to epigenetic age, and the role of cell type heterogeneity remain unclear.

We conduct a comprehensive analysis of 32,000 human blood methylomes from 56 datasets (age range = 6–101 years). We find a significant proportion of the blood methylome that is differentially methylated with age (48% DMPs; FDR 0.005) and variably methylated with age (37% VMPs; FDR 0.005), with considerable overlap between the two groups (59% of DMPs are VMPs). Bivalent and Polycomb regions become increasingly methylated and divergent between individuals, while quiescent regions lose methylation more uniformly. Both chronological and biological clocks, but not pace-of-aging clocks, show a strong enrichment for CpGs undergoing both mean and variance changes during aging. The accumulation of DMPs shifting towards a methylation fraction of 50% drives the increase in entropy, smoothening the epigenetic landscape. However, approximately a quarter of DMPs exhibit anti-entropic effects, opposing this direction of change.

Your thymus isn’t talked about much, but this small organ in your upper chest is a key component of your immune system that is solely responsible for the essential \.

Dissecting the molecular mechanism controlling the epigenetic profile of pluripotent stem cells.„, European Commission.

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A new superhighway network has been identified by researchers, which enables significantly faster travel through the Solar System than was previously feasible. This network can facilitate the transportation of comets and asteroids from Jupiter to Neptune in under a decade and up to 100 astronomical units within a century.

The technology could facilitate swift transportation of spacecraft to the remote regions of our solar system while also aiding in the detection and understanding of nearby objects that pose a threat of colliding with our planet.

In a paper published on November 25, 2020, in the journal Science Advances, researchers have identified a series of interconnected arches forming space manifolds that extend from the asteroid belt to Uranus and beyond, which create a new “celestial autobahn.” These structures operate on a much shorter time scale of several decades, as opposed to the hundreds of thousands or millions of years characteristic of Solar System dynamics.

1Health.io left its customers genetic information unsecured in unencrypted and publicly accessible AWS servers.

“The circumgalactic medium plays a huge role in that cycling of that gas,” said Dr. Nikole Nielsen.

What are the exact sizes of galaxies, and are they bigger than they appear in deep space images? This is what a recent study published in Nature Astronomy hopes to address as an international team of researchers investigated the dust cloud that has long been hypothesized to orbit galaxies, indicating that galaxies are bigger than they appear. This study holds the potential to help scientists better understand the formation and evolution of galaxies, along with where the galaxy ends, and open space begins.

For the study, the researchers examined what’s known as the circumgalactic medium (CGM), which is a gas reservoir that extends far beyond a galaxy’s observable boundary, within a star-forming galaxy located 270 million light-years from Earth. Using novel imaging methods with ASTRO 3D, the researchers were able to observe this galaxy’s CGM extends as far out as 100,000 light-years beyond the galaxy’s observable boundary. Additionally, the team reports the physical aspects of the gas cloud, which is comprised of oxygen and hydrogen, changed as the gas cloud extended farther out.

Continue reading “A New Look at Galaxy Boundaries: Discoveries from Deep Imaging of Cosmic Gas” »

Alzheimer’s, Parkinson’s, and other neurological disorders can be seen as “dirty brain” diseases, where the brain struggles to clear out harmful waste. Aging is a key risk factor because, as we grow older, our brain’s ability to remove toxic buildup slows down. However, new research in mice demonstrates that it’s possible to reverse age-related effects and restore the brain’s waste-clearing process.

“This research shows that restoring cervical lymph vessel function can substantially rescue the slower removal of waste from the brain associated with age,” says Douglas Kelley, a professor of mechanical engineering at the University of Rochester. “Moreover, this was accomplished with a drug already being used clinically, offering a potential treatment strategy.”

Kelley is one of the lead authors of the study, which appears in the journal Nature Aging, along with Maiken Nedergaard, codirector the University’s Center for Translational Neuromedicine. The study is one of many collaborations carried out by researchers at Rochester’s Hajim School of Engineering & Applied Sciences and the Medical Center.

Almost 1.7 million consumers in the US and Canada may have had their data exposed in a massive credit card database breach.

Florida-based Slim CD, a payment processor, is sending emails to customers that their information may have been accessed anytime from August 2023 to June 2024.

The company provides software systems to merchants, allowing them to take any kind of electronic payment, both online and in-person, across variety of hardware.