This study presents an human induced pluripotent stem-cell-based culture model for studying cell state transitions during epithelial-to-mesenchymal transition.
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Epidemiology of cardiovascular–kidney–metabolic syndrome
The cardiovascular–kidney–metabolic (CKM) syndrome paradigm is aimed at reflecting the complex interactions between chronic kidney disease, cardiovascular disease and metabolic dysfunction. Here, the authors discuss current CKM syndrome epidemiological data, examine key determinants of CKM health and consider the potential clinical implications and limitations of the CKM syndrome framework.
Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy
BACKGROUND: SIRT1 (sirtuin 1), a nicotinamide adenine dinucleotide–dependent protein deacetylase.
Regulates cardiovascular inflammation by modulating cellular stress, inhibiting NLRP3.
(NLR family, pyrin domain-containing 3) activation, and promoting the clearance of.
Damaged mitochondria. However, its precise role in the pathogenesis of Kawasaki disease.
VR combined with nerve stimulation improves arm and hand function following a stroke
Researchers at the Medical University of Vienna and ETH Zurich have developed a rehabilitation platform for people suffering from the long-term effects of a stroke that combines virtual reality with targeted sensory nerve stimulation. In a randomized feasibility clinical study with stroke patients, recently published in Nature Medicine, the new technology contributed to improvements in arm and hand function, as well as in tactile and body awareness. These results open up the prospect of personalized and more accessible rehabilitation that can support patients’ recovery beyond the limits of conventional therapy.
Stroke is one of the leading causes of long-term disability worldwide. Even after intensive early physiotherapy, many stroke survivors continue to live with reduced arm and hand function, impaired sensation, and altered body awareness long after the initial event. While conventional rehabilitation can improve motor functions, it often focuses primarily on movement training; sensory deficits and body awareness are frequently given insufficient attention. There is therefore a need for more comprehensive rehabilitation strategies.
To address this need, a research team led by Stanisa Raspopovic (Center for Medical Physics and Biomedical Engineering, MedUni Vienna) has developed “MultiSensy,” a rehabilitation platform for patients with arm and hand impairments following a stroke that combines immersive virtual reality with transcutaneous electrical nerve stimulation. The system turns rehabilitation exercises into interactive virtual tasks designed to train specific arm and hand functions, including reaching, grasping, pinching and forearm rotation.
Survival outcomes and a prognostic nomogram in EGFR-mutant non-small cell lung cancer with leptomeningeal metastasis: a real-world cohort study
Leptomeningeal metastasis (LM) carries a poor prognosis in EGFR-mutant non-small cell lung cancer (NSCLC). This study aims to explore clinical features and survival outcomes and develop a nomogram for overall survival (OS) in this population.
We retrospectively enrolled 288 EGFR-mutant NSCLC patients with LM from Fujian Cancer Hospital (January 2019–March 2024). Prognostic variables were selected by LASSO regression followed by multivariable Cox proportional hazards modeling. Internal validation used 1000-iteration bootstrap resampling. Model performance was assessed by the time-dependent area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analysis.
Median OS was 16.2 months. Before LM, 71.5% of patients received third-generation EGFR tyrosine kinase inhibitors (TKIs), and 76.7% received third-generation EGFR-TKI therapy after LM. Eight variables were identified by LASSO-Cox regression: ECOG performance status (PS), prior lines of systemic therapy, cranial MRI findings, third-generation EGFR-TKI therapy before and after LM, antiangiogenic therapy after LM, chemotherapy after LM, and CNS radiotherapy after LM. Post-LM third-generation EGFR-TKI therapy was the strongest treatment-associated prognostic factor (HR = 2.23; p 0.001), with survival benefit maintained regardless of prior third-generation EGFR-TKI exposure (prior-exposed: HR = 0.60, p = 0.029; TKI-naïve: HR = 0.18, p 0.001). The nomogram demonstrated good discrimination (AUC: 0.777, 0.778, and 0.742 for 6-, 12-, and 18-month OS; C-index: 0.716).
Bioresorbable implant electrically stimulates organs, nerves and muscles then vanishes after treatment
To treat or manage various heart, gastrointestinal and neurological conditions, including arrhythmias, heart block, gastroparesis, epilepsy and some nerve injuries, doctors rely on a technique known as electrical stimulation. Electrical stimulation entails the delivery of small electrical pulses to target locations to prompt the activation of nerves, muscles or organs.
Many existing approaches for delivering electrical stimulation rely on electronic devices that are permanently or temporarily implanted inside the body. These devices can sometimes fail, cause adverse effects and might need to be surgically removed.
Researchers at Northwestern University, Sungkyunkwan University and other institutes recently developed a new implantable and bioresorbable system that could be used to electrically stimulate specific organs, muscles or nerves inside the body. This stimulator, presented in a paper published in Nature Electronics, could gradually disappear after a treatment is complete, so it would not need to be surgically extracted.
AI Companies Don’t Have a Profitable Business Model. Does That Matter?
The generative AI boom is fueled by staggering investments (including OpenAI’s multibillion-dollar chip deals), but for many companies, profitability as a result of these investments has remained elusive, leading some economists to warn of an AI bubble. In this Q&A, Harvard Business School’s Andy Wu wades through the potential and hype of the new technology. In particular, he highlights structural challenges facing most companies and warns of inevitable expiration dates on current legacy subscription models. He says that the industry’s future will depend on sustainable economics and business models that are able to capture value.
The Role of NAD+ in Regenerative Medicine
The understanding of the molecular and cellular basis of aging has grown exponentially over recent years, and it is now accepted within the scientific community that aging is a malleable process; just as it can be accelerated, it can also be slowed and even reversed. This has far-reaching implications for our attitude and approach toward aging, presenting the opportunity to enter a new era of cellular regenerative medicine to not only manage the external signs of aging but also to develop therapies that support the body to repair and restore itself back to a state of internal well-being. A wealth of evidence now demonstrates that a decline in cellular nicotinamide adenine dinucleotide (NAD+) is a feature of aging and may play a role in the process. NAD+ plays a pivotal role in cellular metabolism and is a co-substrate for enzymes that play key roles in pathways that modify aging.
Nine-Valent HPV Vaccination and Related Cancers
This retrospective cohort study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline. We used the TriNetX platform, a large-scale global database, to evaluate the association of 9v-HPV vaccination for adolescent and young males aged 9 to 26 years with HPV-related cancers, including head and neck, penile, rectal, and anal cancers. TriNetX has stored electronic health records for approximately 190 million patients from 170 health care centers globally as of December 2025.17 Data collected in TriNetX included health care visits, diagnoses, procedures, medications, and laboratory results. In this study, the vaccinated cohort included males aged 9 to 26 years receiving at least one 9v-HPV vaccination with a health examination between January 2016 and December 2024. The unvaccinated cohort included males aged 9 to 26 years who underwent a health examination during the corresponding period but never received any HPV vaccination. Age categorization was based on the current recommendation for HPV vaccination.18 ‚19 Details of the data extraction code and cohort selection flowchart are provided in eTable 1 and eFigure 1 in Supplement 1.
The primary outcome in this study was a composite measure encompassing any diagnosis of the following cancers, as defined by the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10): head and neck cancers, penile cancer, esophageal cancer (upper two-thirds only), and anal cancer (eTable 2 in Supplement 1).20 The secondary outcomes included the individual diagnoses of each of the 4 cancers. Data were extracted on February 14, 2026. Outcome follow-up started 180 days after the index date. The index date was defined as the date of the first dose with health examination in the vaccinated group and the date of the first health examination in the unvaccinated group.
The TriNetX platform complied with the Health Insurance Portability and Accountability Act and General Data Protection Regulation.21 Therefore, informed consent was not required because this study utilized only deidentified and aggregated patient data. Although deidentified TriNetX studies generally do not require institutional review board approval,22 this study was reviewed and approved for publication by the institutional review board of Nara Prefecture General Medical Center.