In this Review, Krishna and colleagues draw on clinical and scientific progress in the past two decades to describe the many factors that influence clinical outcomes during adoptive cell therapy using tumour-infiltrating lymphocytes and TCR-engineered T cell therapies. They explain how T cell-intrinsic factors and tumour-specific factors in patients with advanced cancer challenge or promote the success of adoptive cell transfer (ACT), and outline new approaches in the field of ACT.
As ovaries age, their supporting tissue becomes stiffer, and slowing that process may be key to extending fertility.
The space between cells isn’t just an empty void: it’s more like a jelly bath, rich with proteins and other molecules that support the cells suspended within.
It’s also the medium through which important chemical and mechanical signals are transmitted between cells.
Mongiovi, J.M., Babic, A., Sasamoto, N. et al. Ovarian cancer tumor immune profiles associated with intrauterine device and oral contraceptive use. Br J Cancer (2026). https://doi.org/10.1038/s41416-026-03508-9
Immunotherapy is a rapidly evolving field in pediatric neuro-oncology, using diverse strategies to enhance or initiate an antitumor immune response. Its use has expanded from hematologic malignancies to solid central nervous system (CNS) tumors, creating new diagnostic challenges in neuroimaging, particularly in children.
The aim of this review is to summarize current immunotherapeutic strategies for pediatric solid CNS tumors and to discuss their characteristic imaging findings and response patterns, with emphasis on pitfalls in differentiating true progression from treatment‑related inflammatory changes.
Across different immunotherapeutic approaches, a major challenge is distinguishing tumor progression from pseudoprogression, immune‑related flare phenomena, and neurotoxicity. Multiparametric imaging combining advanced MRI techniques and metabolic imaging may improve diagnostic specificity; however, validation in children is limited, and existing response frameworks such as iRANO and RAPNO do not specifically address immunotherapy‑related imaging patterns in the pediatric population.
A blood test for the biomarker phosphorylated tau 217 (p-tau217) recently received federal clearance, but questions have emerged about the extent to which such tests can accurately predict whether a cognitively healthy individual will develop cognitive impairment—a key symptom of Alzheimer’s disease.
A new international study involving researchers across three continents and led by experts from the Mass General Brigham Neuroscience Institute sheds new light on the prognostic value of such tests.
The study found that cognitively unimpaired individuals with very high levels of the biomarker had a 38% absolute risk of developing cognitive impairment over the next five years and a 78% risk over the next 10 years.
The thought of parasites in your food might make you squirm, but they are a reality we must all be wary of.
An outbreak of the parasite Cyclospora in the US, with most cases being reported in Michigan, is a stark reminder of how quickly parasites can spread, even in developed nations.
Michigan health officials have identified lettuce and salad greens as a potential vector for the parasite, since it is transmitted by food and water contaminated by feces.
The properties of ultrathin magnets can be specifically altered by a slight twist between two atomic monolayers. This is the conclusion reached by an international research team led by TU Darmstadt in a study published in Nature Communications. The findings open new prospects for future memory devices.
For the first time, the researchers observed that an extremely thin magnetic material—a so-called two-dimensional van der Waals magnet—” stores” its magnetic state: It responds to a magnetic field and retains some of its magnetization even when the applied field changes. This “memory” is known as hysteresis and forms the basis of many data storage systems.
More than a century after Albert Einstein first transformed our understanding of gravity, his general theory of relativity continues to withstand ever more demanding experimental tests. Now, an international team led by Ignazio Ciufolini at the Chinese Academy of Sciences has carried out the most precise measurement yet of one of the theory’s most subtle predictions: the dragging of spacetime caused by Earth’s rotation.
Published in Nature, the team’s results provide the strongest confirmation to date that Einstein’s description of gravity remains accurate even under extraordinarily precise scrutiny.