The first fully AI-generated movie is heading to theaters. Is Gods Don’t Give Gifts a bold new frontier for filmmaking — or a troubling sign of things to come?
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Introducing Playground: Create and play custom games
Games are one of the most creative forms of expression, and the gaming community keeps growing. But game creation has historically been limited to a select group of people who have technical experience and knowledge of complex game engines.
Today, we’re introducing Playground, an experimental gaming platform that lets you create, play, and share custom games. Playground lowers the barriers to creation, so bringing game ideas to life can now be as easy as describing it through a few prompts — no coding experience required.
With Playground’s conversational interface, you can direct the game just by typing what you want to build. Start from a blank canvas, remix starter prompts, or use guided support to shape your concept — and then test it right away. Want to tweak the physics, rewrite the rules, customize the characters, or overhaul the environment? Just ask. You stay in complete control of the creative direction from rough concept to final product.
GPT-6 for Everyone: ChatGPT Answers With Buttons, Maps and Mini-Apps
Technically, OpenAI relies on a library of ready-made components that the model assembles as it writes. Where plain text works better, ChatGPT is supposed to stick with text. Users who don’t want the visuals can switch them off on the web under “Layout and visuals,” though OpenAI says some graphics may still appear. Intelligent UI is rolling out gradually on the web and in updated apps, but not in the Pro thinking mode or the older desktop apps for macOS and Windows.
More Show Than Substance?
Not everyone is convinced. Wired headlined its take by calling Intelligent UI more show than tell. Search Engine Journal points to another consequence: If ChatGPT builds calculators and converters right in the chat, websites offering those tools will lose visitors. It is also unclear how sources will be displayed alongside graphics and comparisons.
Scientists discover a hidden switch that shuts down inflammation
Inflammation is one of the immune system’s most important defense responses. It helps the body fight infection and repair damaged tissue. But if that response remains active for too long, it can begin to harm healthy tissue and contribute to conditions including arthritis, heart disease, and diabetes.
Scientists have long known a great deal about how inflammation begins. What has been less clear is how the body decides that the danger has passed and shifts from fighting a threat to repairing the damage.
Scientists identify the neuroblastoma cells that signal poor outcomes
Neuroblastoma is the most common solid tumor found outside the brain in children, yet why some children respond well to treatment while others do not has remained poorly understood. St. Jude Children’s Research Hospital scientists and their collaborators built one of the most comprehensive datasets of neuroblastoma cells to date, using it to define the tumor’s cell types and identify a gene signature marking a malignant cell population tied to poor prognosis.
The team also created patient-derived models that capture this population, which older laboratory cell lines had missed. The findings, published today in Cancer Cell, give researchers a new framework and a set of tools to study high-risk neuroblastoma.
Neuroblastoma cells are divided into two cell states: adrenergic cells (which are associated with low-risk disease) and mesenchymal cells (which are associated with high-risk disease, treatment resistance and poor outcomes). However, directly identifying cancer-related mesenchymal cells in patient tumors has been challenging because the body also contains healthy mesenchymal cells, which can be mistaken for their malignant counterparts, complicating efforts to study them.
Advances in Systemic Treatment of Breast Cancer
Systemic therapy for breast cancer has evolved rapidly since 2020, driven by the expansion of targeted therapies, antibody–drug conjugates, and immunotherapy across biologic subtypes. The integration of tumor molecular profiling and germline testing has enabled increasingly personalized, biomarker-guided treatment strategies. In hormone-receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative disease, cyclin-dependent kinase 4 and 6 inhibitors remain foundational, whereas phosphatidylinositol 3-kinase pathway inhibitors, oral selective estrogen-receptor degraders, and antibody–drug conjugates have transformed disease management after endocrine resistance. In HER2-positive disease, antibody–drug conjugates — particularly trastuzumab deruxtecan — have improved outcomes and are being used in earlier lines of therapy, a development that is reshaping treatment paradigms.
Superconducting circuit links smaller photon groups into larger entangled states
Quantum computers, computer systems that leverage the laws of quantum mechanics, store and process information using qubits (i.e., quantum bits). In many quantum computers, qubits are linked via entanglement, a quantum mechanical effect that connects particles in such a way that their shared state cannot be described as separate, independent states.
One key objective of quantum scientists is to realize entanglement between large groups of qubits. This could ultimately help to develop increasingly powerful and sophisticated quantum computers that can tackle complex optimization and computational problems.
Entanglement can be arranged into so-called graph states. The connections between qubits in these states can be described by mathematical networks, which is advantageous for quantum computation and communications.