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In vivo evolution of antibody CR3022 expands cross-neutralization of SARS-CoV-2 variants and informs pan-sarbecovirus immunity

Fu et al. use Ig-humanized mice expressing the germline CR3022 heavy chain to reveal how somatic hypermutation rapidly adapts this antibody class for broad sarbecovirus recognition. Sequential immunization drives CR3022-like maturation, while structural analyses show that increased affinity and breadth arise from subtle polar and electrostatic refinements.

Asymmetry Control in a Parametric Oscillator for the Quantum Simulation of Chemical Activation

Researchers have demonstrated a superconducting quantum circuit that simulates tunneling in chemical reactions, revealing unexpected quantum effects in state transitions.

The work enables controlled study of quantum dynamics in chemistry-like energy landscapes and highlights superconducting circuits as powerful tools for exploring chemical processes.

Read more in PRX Quantum.


A continuously driven Kerr parametric oscillator simulates a dissipative quantum system with applications to reactions in quantum chemistry.

Is consciousness more fundamental to reality than quantum physics?

The idea that everything that exists can be built from the bottom up has long held sway among physicists. Now, a new kind of science is under construction that centres conscious experience – and might unravel the universe’s biggest mysteries.

By Karmela Padavic-Callaghan

The Science of PROJECT HAIL MARY

I talk about the science of Project Hail Mary and why it makes the story feel so grounded, exciting, and believable.

From microbes in space to the real challenges of long-duration space travel, this section looks at how the movie uses science as more than just background decoration. It also gets into why stories like this feel so refreshing right now, because they make curiosity, intelligence, and problem-solving feel dramatic again.

This is a conversation about the real science behind Project Hail Mary, what NASA’s work has to do with the movie, and why science fiction can still inspire wonder.

FULL EPISODE: • PROJECT HAIL MARY: Hope, Science, and Huma…
Listen to Project Hail Mary: https://amzn.to/3OSuE0K
Wear Project Hail Mary: https://amzn.to/4cY4vqy.
Fist My Bump: https://amzn.to/42nq1yN

Patreon: https://tinyurl.com/EgoPatreon.

Scientists create electronic devices that function reliably at extreme temperatures from 500 degrees Celcuis to absolute zero — advanced semiconductor material unlocks new possibilities in space tech and quantum computing

The technology has massive potential in space technology and quantum computing

Scientists Discover a Key Difference in Brains That Resist Alzheimer’s

The brain changes associated with Alzheimer’s usually lead to a severe loss of memory and cognitive abilities, but not always.

Now, a new study led by a team at the University of California, San Diego (UCSD) helps explain why.

Based on postmortem brain research, around 20 to 30 percent of older adults are thought to have asymptomatic Alzheimer’s disease (ASYMAD). Their brains have the characteristic buildup of misfolded amyloid-beta and tau proteins, but they show no detrimental mental effects.

The Space Habitat Diaspora — Humanity Spreads Without Planets

Humanity may not colonize planets—we may build our own worlds. Explore how rotating space habitats could spread across the Solar System and beyond, forming a vast diaspora of artificial worlds that reshape civilization and interstellar expansion.

Get Nebula using my link for 50% off an annual subscription: https://go.nebula.tv/isaacarthur.
Watch my exclusive video Settling Saturn’s Rings: https://nebula.tv/videos/isaacarthur–… SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: The Space Habitat Diaspora – Humanity Spreads Without Planets Written, Produced & Narrated by: Isaac Arthur Graphics from Bryan Versteeg, Jeremy Jozwik, Sergio Botero, Udo Schroeter Select imagery/video supplied by Getty Images 0:00 Intro — Rethinking What a World Can Be 2:37 Why Habitats Win on Physics, Engineering… and Scalability 10:13 The Birth of a Habitat Civilization 14:54 Nebula 15:54 Life Without Planets: Cultures That Grow in Steel Valleys 18:59 Resilience: Fragile Shells, Immortal Civilizations 21:37 The True Diaspora: Leaving the Solar System.

🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall
🌐 Visit our Website: http://www.isaacarthur.net.
❤️ Support us on Patreon: / isaacarthur.
⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a
👥 Facebook Group: / 1583992725237264
📣 Reddit Community: / isaacarthur.
🐦 Follow on Twitter / X: / isaac_a_arthur.
💬 SFIA Discord Server: / discord.
Credits:
The Space Habitat Diaspora – Humanity Spreads Without Planets.
Written, Produced & Narrated by: Isaac Arthur.
Graphics from Bryan Versteeg, Jeremy Jozwik, Sergio Botero, Udo Schroeter.
Select imagery/video supplied by Getty Images.

0:00 Intro — Rethinking What a World Can Be.
2:37 Why Habitats Win on Physics, Engineering… and Scalability.
10:13 The Birth of a Habitat Civilization.
14:54 Nebula.
15:54 Life Without Planets: Cultures That Grow in Steel Valleys.
18:59 Resilience: Fragile Shells, Immortal Civilizations.
21:37 The True Diaspora: Leaving the Solar System.

Claude-powered AI coding agent deletes entire company database in 9 seconds — backups zapped, after Cursor tool powered by Anthropic’s Claude goes rogue

PocketOS founder blames ‘Cursor running Anthropic’s flagship Claude Opus 4.6’ plus Railway’s infrastructure for data disaster.

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