Aging disrupts microglial function, but factors that rejuvenate these cells are poorly characterized. Here, the authors show the youth-associated protein TIMP2 revitalizes microglia by altering inflammatory states and restoring phagocytosis.
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MIT engineers connect bacteria to create living transistors
MIT researchers have engineered bacteria that can function as transistors, allowing the team to create living “circuit boards” that can be printed onto a growth medium in a Petri dish.
In electrical circuits, transistors function as switches that can turn current on or off. In the biological circuits that the researchers have created, bacterial switches control the flow of small molecules, which send signals to downstream circuit components.
The research team designed two different transistors, along with three bacterial strains that relay information between the transistors, giving them the building blocks they need to design nearly any type of circuit. In a new study, they used these cells to create circuits that can add two or three inputs, or send one input to a specific location in the circuit.
NASA’s Starling Mission Opens New Frontiers in Space Navigation
NASA’s Starling mission has marked another milestone in spacecraft autonomy by using a new system that determines a satellite’s position in orbit by referencing other objects in space, instead of relying on a navigational network.
The FALCON (Fast Autonomous Lost-in-space Catalog-based Optical Navigation) technology demonstration is a step toward spacecraft being able to operate more independently. As NASA prepares for more missions beyond Earth’s orbit, technologies like FALCON can support lunar satellite swarms, distributed science missions, and human exploration.
Traditional satellite navigation depends on GPS signals, but those can be unreliable or unavailable in lunar or deep space environments. The FALCON payload is a joint flight experiment by NASA and EraDrive, a startup spun out from Stanford University. It combines EraDrive’s Era-Core flight software and embedded algorithms with Starling’s cameras and an onboard catalog of known satellites to support GPS-independent navigation and space situational awareness.
Next Generation of Planetary Scientists Learn Public Engagement Skills
The NASA Science Mission Directorate (SMD) Community of Practice for Education (SCoPE) – part of the NASA Science Activation (SciAct) Program portfolio – enables Earth and Space Science and Engineering Subject Matter Experts (SMEs) – especially NASA-funded SMEs – to efficiently and effectively share their science with support from SciAct education experts.
In Summer 2026, NASA SCoPE partnered with Arizona State University’s Facility for Open Research in a Compressed Environment (FORCE) Summer School to help seven undergraduate student interns build the science communication skills needed to share their research with a variety of audiences. FORCE is a world-class laboratory that uses high-pressure experimental equipment to recreate the extreme conditions found deep within Earth and other planetary bodies, enabling researchers to better understand how planets form, evolve, and behave under immense pressures.
As part of the Summer School, SCoPE facilitated two hands-on workshops on June 25 and 26, followed by office hours the following week, to help interns translate their technical research into compelling stories for non-expert audiences. The training focused on identifying the central themes of their work, developing clear and engaging messages, planning effective visitor interactions, and thinking through the logistics of public engagement. Interns also received guidance on preparing both their research posters and individual outreach stations.
Clinical and translational progress in oncolytic virotherapy for pediatric CNS tumors
Pediatric central nervous system (CNS) tumors are the leading cause of cancer-related mortality in children. Development of more effective therapies for pediatric CNS tumors has been slow, underscoring an urgent need for novel and innovative approaches.
This review summarizes current pediatric clinical trials of oncolytic viruses for pediatric brain tumors including high-grade glioma (HGG), diffuse midline glioma (DMG), medulloblastoma (MDB), atypical teratoid rhabdoid tumors (ATRT), and other high-grade tumors, while highlighting limitations of early-phase data, exploratory biomarkers, imaging challenges, pseudoprogression, and future directions.
Key platforms include HSV-based agents (HSV1716, G207, and M032); adenoviral vectors (DNX2401, Ad-TD-nsIL12, and ICOVIR-5); MV-NIS (measles virus); PVS-RIPO (poliovirus); and Reolysin (reovirus). We review trial status, innovations in viral engineering and delivery, combinatorial strategies and translational challenges to establish oncolytic virotherapy as part of the future standard care for pediatric brain tumors.
Flexible brain circuits can switch between different tasks
“We found that the brain doesn’t dedicate a separate group of neurons for every type of information. Instead, it uses the same populations of neurons to perform the same computation on different kinds of information, which means the same subset of neurons can hold both an action and a sensory stimulus in working memory,” says Yuma Osako, an MIT postdoc and the lead author of the new study.
As we move through everyday life, our brains engage in a huge variety of cognitive tasks. For example, during a grocery run, we might have to recall the items for a recipe, remember where the clerk said the flour was located, and count out money to pay.
Scientists have long theorized that the brain contains modules, or clusters of neurons, that perform the same computation across many different types of tasks. This type of modularity could help explain why our brains are able to take on so many functions, with little difficulty.
In a new study of mice, MIT neuroscientists have found the first evidence for the existence of these flexible modules. They identified neurons in the prefrontal cortex that can be used to store either a sensory input or an action plan in working memory.