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Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains

Activity-based proteomics reveals a conserved decline in deubiquitylating enzyme activity in the aging vertebrate brain driven by oxidative stress. Antioxidant treatment restores activity, identifying redox-sensitive DUBs as early drivers of proteostasis decline.

Phosphoinositide Depletion and Compensatory Phospho-Signaling in Angiotensin II-Induced Heart Disease

Westhoff & colleagues found that PTEN inhibition reduces cardiac fibrosis caused by the high blood pressure hormone AngII. Learn how to fight fibrosis from hypertension at.


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Chip Can Project Video the Size of a Grain of Sand

Engineers have created a 1-square-millimeter chip that can project a photograph onto an area smaller than the size of two human egg cells. This precise laser control could have applications in augmented reality, biomedical imaging, and quantum computing.


MEMS array to steer lasers for quantum computer finds other uses.

Deep under Antarctic ice, a long-predicted cosmic whisper finally breaks through in 13 strange bursts

A detector buried deep in Antarctic ice has captured the first experimental evidence of a predicted but never-before-seen phenomenon: radio pulses generated when high-energy cosmic rays slam into the ice sheet and trigger particle cascades inside it. Through results published in Physical Review Letters, astronomers of the Askaryan Radio Array (ARA) Collaboration have validated a key technique, which they hope will eventually allow them to detect some of the rarest and most energetic particles in the universe.

In 1962, Soviet physicist Gurgen Askaryan predicted that high-energy particles passing through a dense material should produce a distinctive burst of radio waves. When such a particle strikes an atom, it triggers a cascade of secondary particles that sweeps up electrons from the surrounding material, creating a negatively charged shower front that radiates at radio frequencies.

This “Askaryan radiation” was later confirmed in lab experiments and detected in air, but observing it in ice proved far more challenging. This is partly due to the difficulty of distinguishing genuine signals from the many sources of radio noise in polar environments, and partly because the simulations needed to model the effect in ice have only recently become sophisticated enough to make such rigorous analysis possible.

Engineered internal architecture of core-shell lipid nanoparticles promotes efficient mRNA endosomal release

Li et al. show that putting gold nanoparticles inside of LNPs causes marked improvements in endosomal escape efficiency, describe a likely mechanism, and test their complexes with two therapeutic contexts in mice. A simple innovation which could greatly enhance LNP delivery!


Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid–coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.

Light-powered spaceships could get to our nearest star in 20 years. Fiction? Scientists say it could become fact

That would mean generations upon generations of human lifetimes, all lived out on board a rocket ship travelling across space, in the hope of a comfortable utopia waiting for us when we arrive.

Now, a team of researchers say they’ve demonstrated a form of light-driven propulsion that could one day get us to Alpha Centauri in 20 years.

A team of researchers at the J. Mike Walker ’66 Department of Mechanical Engineering at Texas A&M University say they’ve demonstrated lasers can be used to lift and steer objects without physical contact.

Gerard k. O’neill Was Not Honored as Deserved, so Far… But Maybe It’s Not Too Late!

While doing research during the works of the SRI 4th World Congress, I am trying to deepen my knowledge of the immense work done by Gerard K. O’Neill and his Space Studies Institute (SSI) during the second half of the past century.

Gerry took the work where Tsiolkovsky, Oberth, von Braun, and others had left it, on the great theme of rotating habitats in free space. And more, the SSI, founded by him, has developed an incredible amount of very high-profile studies about space manufacturing [1], covering many aspects of living in free-space habitats. Not only scientific and technical issues. According to the O’Neill teachings—as his main references, like Krafft Ehricke and others, had done—human requirements, attention to life and health protection, human rights, and social needs informed all of the developed studies and conceptual design.

Great outreachers like Isaac Asimov, Arthur Clarke, and Stanley Kubrick were ready to follow O’Neill and promote his concepts in their artworks and in their interviews to TV and media magazines.

A new way to deliver faster, greener wireless connections indoors

Modern life depends on fast and reliable wireless connections. Video calls, streaming services, virtual reality, and smart devices all place growing demands on networks that already serve billions of users. Most wireless data today travels through radio-based technologies such as Wi-Fi and cellular systems.

While these approaches have been highly successful, they face mounting challenges, including crowded radio spectrum, interference in dense indoor spaces, and rising energy consumption as more devices come online.

A promising complementary approach is optical wireless communication, which uses light instead of radio waves to transmit data. Light offers far more bandwidth than radio frequencies, does not interfere with existing wireless systems, and can be directed precisely at specific locations.

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