New Northwestern Medicine research published in Nature Communications suggests that a metabolite produced by gut bacteria when they digest dietary fiber can leave a lasting molecular imprint on intestinal cells, promoting immune tolerance and protecting against inflammatory bowel disease-like conditions long after exposure ends.
Yingzi Cong, Ph.D., the Stanley Gradowski Professor of Gastroenterology and a professor of Microbiology-Immunology and Pathology, was the senior and co-corresponding author of the study.
Marcus’ legacy lives on, and his philanthropic foundation now nods to one of his original passions: medicine.
https://marcusfoundation.org/” href=“https://marcusfoundation.org/”>The Marcus Foundation, established in 1989 by Bernie and his wife, Billi, donated $28.7 million to Dr. Chuck Murry, director of the University of Southern California’s Stem Cell Center, to advance clinical trials of stem cell-based therapies to regenerate damaged tissue after a heart attack.
“Murry and his team have advanced gene-edited cellular therapy to the point that the time is right to support cells as living medicine in this new form of treatment,” Jonathan Simons, chief science officer of The Marcus Foundation, said in a statement.
Jaw-dropping patient videos and miraculous testimonials ignited a frenzy in China over a technique that aims to improve drainage from the brain. Now it is entering trials worldwide.
Machine Party, a recently released collection of brutal party games from developers GDeavid and Mike Klubnika, the creator of Buckshot Roulette and s.p.l.i.t., received an update, with version 2.0 introducing couch co-op.
The developers also announced that the game has sold over 1 million copies, thanking the community for their support.
Machine Party can now be played on a TV, allowing players to gather with controllers and enjoy the game together on the big screen. To access couch co-op, players need to connect up to four controllers, navigate to Local in the menu, and select either Original, Custom, or Arcade; once in the lobby screen, users can press any button on one of the controllers to join. The developers noted that one player can also use keyboard and mouse, so for a group of four, only three controllers would be needed.
Software defined vehicles offer advantages their analog rivals can‘t compete with. But the hardware and software in them needs to be maintained, and some owners have found their cars suddenly obsolete or without key features. CNBC talked with industry figures, including Rivian Chief Software Officer Wassym Bensaid about the promise of software defined vehicles and how his company is trying to handle the challenges this new form of ownership poses.
Chapters: 00:00 Introduction. 01:22 Chapter 1: Software-defined cars. 02:34 Chapter 2: The problem. 04:39 Chapter 3: Keep it running.
Produced by: Robert Ferris. Shot and edited by: Darren Geeter. Additional Camera: Andrew Evers. Senior Managing Producer: Tala Hadavi. Additional footage: Getty Images.
Aubrey de Grey believes ageing is accumulated damage in a biological machine and argues that medicine may eventually become capable of repairing that damage faster than it appears. He gives humanity a 50/50 chance of reaching what he calls “longevity escape velocity” within the next 12–15 years.
Peter and Aubrey discuss why the body ages, the seven categories of damage that must be repaired, stem-cell and gene therapies, the mouse experiment that could transform the field and why Aubrey believes rejuvenation treatment will ultimately be available to everyone rather than reserved for the wealthy.
They also explore what happens to population, work, fertility, relationships, religion and the meaning of life if people stop getting sick from ageing. Aubrey explains why AI cannot replace the missing biological experiments, why longevity research remains so difficult to fund, and why he is driven by the 110,000 people he says die from ageing-related causes every day.
TIMESTAMPS: 00:00:00 — Trailer. 00:00:48 — Can We Cure Ageing? 00:04:24 — The 12–15 Year Prediction. 00:06:17 — The Body Is a Machine. 00:15:21 — How Aubrey Entered Longevity. 00:18:45 — Would You Want to Live Forever? 00:20:15 — Does Longevity Change Risk? 00:21:53 — Will Population Explode? 00:24:22 — Can You Choose Your Age? 00:30:19 — The Seven Types of Ageing Damage. 00:36:54 — What Rejuvenation Treatment Looks Like. 00:45:35 — Will It Be Expensive? 00:48:39 — Who Would Refuse It? 00:53:00 — Why Longevity Research Lacks Funding. 00:56:02 — The Mouse Experiment. 01:00:18 — The Breakthrough That Changes Everything. 01:01:35 — Does Death Give Life Meaning? 01:05:22 — Bryan Johnson and AI 01:12:32 — AlphaFold, AGI and AI Risk. 01:15:13 — Why Funding Is So Hard.
Because adding a quick instruction to an AI’s guide file is fast and low-risk, developers continually tack on new rules whenever the AI makes a mistake (e.g., “Don’t use library X,” or “Always run tests with flag Y”). Over time, however, the original context and reasoning behind older instructions fade from human memory.
Agent instruction files like CLAUDE.md exhibit unbounded growth due to “catastrophic remembering,” a process where the original rationale for instructions is lost, making safe deletion difficult…
