A large study shows that machine-learning clocks based on speech can estimate chronological age and may also offer a window into brain aging, biological aging, cognitive health, cumulative burden, and dementia.
The new study, just published in leading international journal Science Advances, outlines that researchers have developed a “speech clock” that can estimate a person’s chronological age from hundreds of acoustic and linguistic characteristics of their speech. The difference between a person’s actual age and their speech-predicted age (called the speech age gap) was also associated with multiple independent markers of biological aging, brain health, cognition, social adversity, and dementia.
The study analyzed 2,928 Spanish-speaking participants from Argentina, Chile, Colombia, Mexico, and Peru, including healthy adults and people with mild cognitive impairment, Alzheimer’s disease, and different forms of frontotemporal dementia. Rather than looking at a single property of the voice, the researchers used machine learning to analyse hundreds of features capturing how people speak and what they say: incorporating speech rate and pauses, pitch, emotional content, vocabulary, semantic precision, and the amount and organisation of verbal output. Machine-learning models combined these features to estimate chronological age and generate an individual speech age gap.









