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How bacteria use acetyl coenzyme as a building block in the formation of cells

Researchers at the University of Greifswald have discovered a new mechanism by which bacteria such as Bacillus subtilis can regulate the production of the central metabolic molecule acetyl coenzyme A (Acetyl-CoA). Acetyl-CoA, also known as activated acetic acid, is crucial in the production of nutrients, i.e., proteins, carbohydrates and lipids, and thus plays a key role in the metabolism of all cells.

Until now, it was unclear how bacteria coordinate the production and decomposition of activated acetic acid using this pathway. New findings published in the journal Nature Communications have now shown that Bacillus subtilis uses a special regulatory mechanism to coordinate both processes.

When cells are supplied with an abundance of nutrients, they are forced to decide whether to gain energy or create building blocks for growth. At the heart of this decision-making process is acetyl coenzyme A, which links the decomposition of nutrients with the synthesis of proteins, carbohydrates and lipids, thereby acting as a central hub for the entire metabolism during cell formation.

Waymo unveils virtual driver model to test autonomous car crash avoidance

Autonomous vehicles are already a reality on some of our streets and could become a major part of future transportation systems. Safety, of course, is the main concern, as with all vehicles. To help evaluate and improve its autonomous driving technology, U.S. driverless vehicle company Waymo has created a virtual representation of human driver behavior in near-crash situations.

Human drivers avoid collisions by instantly perceiving a hazard, deciding how to react and then executing the maneuver. It all happens in a split second thanks to the central and peripheral nervous systems working together harmoniously.

Currently, testing and training for collision avoidance involve several systems, and each often tests only a specific scenario or metric. For example, one system might only look at what happens when a lead vehicle brakes suddenly. They do not capture the whole sequence of events from detection to actual avoidance.

New water-based material could store solar energy, power reactions in darkness, then recharge

Northwestern University scientists have developed a new liquid material that charges like a battery, transforms like a living organism and then resets itself in open air. Traditionally, harvesting energy, storing it and using it require separate materials or devices. The new platform merges all three functions into a single material, opening the door for adaptive, clean, renewable systems that don’t require plastics or metals.

The study is published in Chem. It marks the first report of a material that stores energy by physically rebuilding itself.

To design the material, the researchers drew inspiration from the cytoskeleton —a cell’s dynamic internal scaffold that enables it to maintain its shape, move and divide. Unlike animals’ rigid skeletons, cytoskeletons constantly build, dismantle and rebuild themselves. Northwestern’s new material behaves in a similar way, repeatedly assembling and disassembling as it stores and releases energy. But instead of running on biological fuels, it is powered by electrons harvested from sunlight, electricity, X-rays and other energy sources.

Researchers identify brain ‘entrapment’ patterns associated with depression

Researchers at the Icahn School of Medicine at Mount Sinai have identified distinctive patterns in how the brain transitions between activity states in people with depression, providing new insight into why depressive symptoms can feel persistent and difficult to overcome.

Published online in Nature Communications, the study combined advanced neuroimaging techniques with mathematical modeling to examine how the brain moves between functional activity states over time. The findings suggest that depression may involve a form of “brain-state entrapment,” in which the brain becomes more likely to enter certain patterns of activity and less likely to transition out of them.

“Many patients describe depression as feeling stuck in negative patterns of thought, mood and behavior,” said Yael Jacob, Ph.D., assistant professor of psychiatry at the Dennis S. Charney, MD, Depression and Anxiety Discovery Center at the Icahn School of Medicine at Mount Sinai and senior author of the paper. “Our findings suggest that this experience of being ‘stuck’ may reflect measurable changes in the brain’s underlying dynamics.”

Light rewrites magnetic memory in one pulse, opening path to lower-power AI chips

As artificial intelligence, cloud computing and digital services continue to expand, the world is facing a growing need for faster and more energy-efficient ways to store and process information. A team led by the National Institutes for Quantum Science and Technology (QST) has developed a new magnetic memory material that can be rewritten using laser light instead of electric current, a step that could help reduce power consumption in data centers and support future high-speed information systems.

The study is published in Applied Physics Letters.

The new material allows magnetic information to be switched by a single ultrashort laser pulse. Because light can reverse magnetic states much faster than electric current, the approach could deliver switching speeds roughly 1,000 times higher than those of conventional electrically driven magnetic memory while also reducing heat generation and energy loss.

This specially-designed jacket pulls drinking water from thin air

Engineers at The University of Texas at Austin have developed a jacket that harvests drinking water directly from the air. The technology could benefit anyone who spends a lot of time in areas without easy access to drinking water, from hobbyist hikers, campers and runners to agricultural workers, emergency responders and soldiers. The advance in fabric technology comes alongside a new benchmark for atmospheric water harvesting.

“Water harvesting from air is usually imagined as a stationary device such as a box, a panel or a large sorbent bed,” said Guihua Yu, chair professor of the Cockrell School of Engineering’s Walker Department of Mechanical Engineering and Texas Materials Institute and one of the leaders of the new research appearing in Science Advances. “Here, we wanted to rethink the form of the technology. If the fabric itself can collect water from air, it opens a new direction for personal and portable water access.”

The textile incorporated into the jacket collects moisture and funnels it to detachable harvesting units. Those units are placed in a foldable collector piece and heated to produce water.

Cosmic dawn fuel discovery unlocks early galaxy growth secrets

Astronomers have discovered a huge reservoir of cold molecular gas, the direct fuel for star formation, in REBELS-25, a massive, star-forming galaxy. The team, led from Leiden University, focused on REBELS-25, seen when the universe was only about 700 million years old, around 5% of its current age. The research is published in the journal Monthly Notices of the Royal Astronomical Society.

Astronomers use “redshift” to describe this distance, which measures how much the universe’s expansion has stretched a galaxy’s light to redder wavelengths. The higher the redshift, the farther back in time we look. REBELS-25 sits at redshift z = 7.3, deep in the Epoch of Reionization, a key era in which the first stars and galaxies transformed the dark, neutral universe into the universe we see around us today.

Galaxies grow by turning gas into stars, and cold molecular gas is the primary fuel. Until now, astronomers suspected early bright, massive galaxies had huge gas supplies, but no one had directly detected them at these distances.

Physicists introduce phase contrast to electron microscopy, delivering sharper images of our body’s tiniest proteins

Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside cells that had previously been too faint or washed out for biologists to study.

UC Berkeley physicists have now adapted the phase-contrast technique to the electron microscope, which has about 10,000 times the magnification of microscopes using optical light. The study is published in the journal Science.

The addition of a so-called laser phase plate has the potential to greatly improve cryoelectron microscopy (cryo-EM), a technique for determining the structure of molecules that itself revolutionized the understanding of proteins and accelerated new drug discovery starting a decade ago.

Organic molecule with ultranarrow emission spectrum could lead to better LEDs

Over the past several decades, light sources have gradually transitioned to light-emitting diodes, or LEDs, and inorganic LEDs are now used across a wide range of applications. In parallel, organic LEDs, or OLEDs, have become widely used in display technologies.

OLEDs in particular offer significant advantages in devices such as smartphones, including higher resolution and lower power consumption. All LEDs operate based on spontaneous emission, which is inherently broadband, and OLEDs in particular produce broad emission spectra.

Narrowing this spontaneous emission toward a monochromatic limit would greatly increase its utility, a goal that has long been a central pursuit in photonics. For example, a narrower emission would achieve more highly saturated colors in LED-based displays.

Newly synthesized fullerene material remains metallic even under low temperatures

An international team whose research was coordinated by Osaka Metropolitan University (OMU) has reported the survival of metallic behavior in the strongly correlated molecular material ytterbium cesium fulleride (Yb₂CsC₆₀). The electrons in the newly synthesized material remained mobile and continued to conduct electricity even at the lowest temperatures studied, despite strong electron interactions that would normally be expected to drive the material into an insulating state.

The findings were published in Nature Communications.

In materials such as metals, electrons move freely, allowing them to conduct electricity. However, as interactions between electrons become stronger, freedom of motion can be suppressed. Under these conditions, materials undergo a phenomenon known as a Mott metal-insulator transition, where they change from a conducting metal into an insulating state in which electrons become effectively immobile.

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