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A computer that runs on living human neurons is currently playing Doom. It’s called CL1, built by Cortical Labs from brain cells grown in a lab. There’s no one at the controls, and yet something is clearly learning. What’s actually running this thing is the strange part, and it’s the reason I had to make this video.

Inspired by TRY: • La découverte la plus effrayante du siècle.

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New tissue atlas aims to help AI understand cancer

How cells are arranged within tissue can reveal as much about disease as the cells themselves. When doctors examine a cancer tumor, for example, they don’t just look at which cells are present; they also want to know how those cells are arranged and how they interact with each other. That’s because the way cancer cells interact with neighboring immune cells can offer important clues about how a disease develops or responds to treatment.

Scientists can study these relationships using spatial proteomics, a technology that captures this organization by measuring dozens of proteins while preserving their locations. Because proteins help control what cells do, these images offer a valuable picture of how healthy and diseased tissues work.

But the resulting data sets are difficult to combine. Research laboratories around the world use different equipment, examine different proteins and store their results in different ways. Combining this information is complicated and time-consuming, making it difficult to use large amounts of data for both conventional studies and, now, training artificial intelligence.

Peritumoral adipose tissue: A bidirectional regulator of cancer

This review synthesizes evidence that peritumoral adipose tissue and tumors dynamically reshape one another through metabolic, immune, and stromal interactions across cancer types. It highlights how this bidirectional crosstalk creates tumor-supportive niches and may reveal therapeutic opportunities for disrupting the adipose-tumor axis.

Cancer-Associated Adipocytes in the Tumor Microenvironment

These stimuli suppress adipogenic markers while activating pathways associated with inflammation, fibrosis, and extracellular matrix remodeling. As a result, CAAs acquire fibroblast-like features and contribute actively to tumor progression.

CAAs are most commonly found at the invasive front of tumors, where cancer cells interact directly with surrounding adipose tissue. This strategic localization allows CAAs to:

New Roles for the Cell’s Powerhouse Uncovered in Catalog of Mitochondria

A research consortium has generated a catalog of mitochondrial proteins across eukaryotic organisms, capturing the organelle’s diversity across the tree of life and revealing clues to its origin and role in the evolution of complex-celled organisms.

Gram-Negative Bacterial Resistance

The rapid worldwide spread of antimicrobial resistance among gram-negative bacteria is driven by a complex interplay of human, environmental, and health care–associated factors and accelerated by mobile genetic elements that facilitate the dissemination of resistance genes. Resistance in gram-negative bacteria arises primarily through reduced drug entry, active drug efflux, modification of antibiotic targets, and enzymatic drug inactivation, most notably through β-lactamase production. Clinically important resistant pathogens include extended-spectrum β-lactamase–producing Enterobacterales, carbapenem-resistant Enterobacterales, Pseudomonas aeruginosa with difficult-to-treat resistance, and carbapenem-resistant Acinetobacter baumannii.

Customizable DNA labels can selectively guide drug carriers to cancer cells

Cells naturally send tiny packages to one another to share information. Researchers at Carnegie Mellon University have developed a simple, low-cost way to turn those packages into drug carriers that can deliver treatments directly to cancer cells, potentially improving effectiveness while reducing side effects.

“Modern anticancer drugs are strong already. What we really need is precision. So, how do we deliver things to cells precisely? I believe that the best solution is the one that nature has already made for us,” said Christopher Blum, a Ph.D. candidate in the Department of Chemistry.

Blum developed a new platform that modifies naturally occurring cellular transport vesicles so they can deliver therapeutic cargo to specific cells while avoiding unintended targets. The research is published in ACS Applied Bio Materials.