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This unusual epigenetic modifier promotes certain cancers but suppresses others

The epigenetic modifier MLL4 has an unassuming name—the 4, for instance, indicates it’s just one in a family of such modifiers. But MLL4 is quite special: In a specific type of leukemia, it drives disease progression, while in solid tumors, it acts as a suppressor.

The paradoxical nature of MLL4 made it a compelling enigma for Rockefeller University’s Robert Roeder, a pioneer in the field of genetic transcription. Now his Laboratory of Biochemistry and Molecular Biology at Rockefeller University has used a combination of biochemistry, genetics and structural biology to find surprising new characteristics of MLL4 that expand our understanding of its range of functions, including its relationship to a tumor-suppressing protein. The findings, published in Molecular Cell, could illuminate how the MLL4 complex helps switch genes on—including cancer genes in leukemia.

“This research demonstrates that MLL4 has functions in transcription that were entirely unknown before,” says Roeder. “And because MLL4 is a key regulator of gene activity, it’s important to understand how it works—especially in cancer cells.”

A Simple Search for Tiny Charges

Decades-old experiments have now been enlisted to set new bounds on the properties of a hypothetical particle that bears a tiny fraction of the electron’s charge.

One candidate for the mysterious dark matter believed to pervade the Universe is a hypothetical form of matter called millicharged particles (mCPs), which carry a tiny fraction of the charge on an electron. A research team has now proposed that such particles, if they exist, might be detected by letting them accumulate in simple laboratory-scale devices already used for creating and measuring electric charge [1, 2]. The team has shown that previous measurements made with such devices can be used to set new limits on the properties of mCPs.

The standard model of particle physics accommodates the 17 particles that make up regular, visible matter, but researchers are seeking to extend it to include gravity or dark matter or both. Dark matter seems to be demanded by astronomical observations and—aside from its gravitational interactions—should interact minimally, if at all, with light and with other matter.

Warm Jupiter exoplanet transiting a sun-like star discovered

An international team of astronomers reports the discovery of a new exoplanet orbiting a sunlike star as part of the Next Generation Transit Survey (NGTS). The newfound alien world, designated NGTS-39 b, is a Jupiter-sized planet with an equilibrium temperature of about 519 K. The discovery was detailed in a paper published July 2 on the preprint server arXiv.

NGTS-39 (also known as TIC-453147896) is a relatively bright star of spectral type F9 located some 910 light-years from Earth. The star was observed multiple times between 2019 and 2024 with NASA’s Transiting Exoplanet Survey Satellite (TESS), which detected a transit signal in its light curve.

Now, a group of astronomers led by Ioannis Apergis of the University of Warwick, UK, have used NGTS’ 12 robotic Newtonian telescopes to perform follow-up photometric observations of NGTS-39. This, together with radial velocity measurements from CORALIE and HARPS spectrographs, allowed the team to confirm the planetary nature of the TESS-detected signal.

Children back group claims over evidence, but privacy reduces bias, experiments reveal

As we move closer to Election Day 2026, voting preferences are moving back into focus—and with them, analyses of what drives partisanship at the polls. However, less frequently asked is when Americans show evidence of partisan behavior: shortly or well after reaching the legal voting age? As teenagers? In elementary school?

A team of psychology researchers has found evidence of partisan behavior in children ages 5 to 9—they frequently endorsed their own group’s claims even when evidence suggested otherwise, indicating group affiliation influenced their responses. However, the scientists also uncovered a potential remedy to such responses: When incentivized to tell the truth about what they had seen or when they could provide answers under the veil of privacy, the children were much less likely to adopt their own group’s claims. The paper is published in the journal Cognition.

“Even young children will side with their group over the evidence of their own eyes, but mainly when they’re responding publicly and when being accurate doesn’t count for much,” explains Andrei Cimpian, a psychology professor at New York University and the senior author of the paper. “However, if you allow them to respond in private or give them a reason to care about accuracy, the partisanship effect disappears.”

China takes a page from SpaceX and recaptures the first stage of a rocket to reuse it

China successfully recaptured the first stage of a rocket after a launch on Friday in a breakthrough for the country’s space program, state media said.

The first stage of a Long March-10B rocket separated from the second stage after liftoff and returned to a platform in the sea, the official Xinhua News Agency said.

It was the first time China recovered the first stage of a rocket. America’s SpaceX has been doing so for several years to drive down launch costs by reusing the booster that helps lift the satellites or whatever the rocket is carrying into space.

Researchers find simple solution for extending the lifespan of LEDs made from glowing quantum dots

A new study led by MIT researchers could drive the development of more energy-efficient digital displays—such as flat-screen TVs, augmented and virtual reality headsets, smartphone screens, medical imaging devices and even large-area ambient lighting surfaces—that also generate richer, brighter colors.

The MIT scientists, in collaboration with researchers at Samsung, studied the microscopic changes that occur inside LEDs that use electrically excited quantum dots, which are precisely shaped nanoscale semiconductor particles that emit extremely pure colored light. The research appears in Science Advances.

Quantum dots are currently used in some of the computer and television displays with the best picture quality available. The efficiency of these displays could be further improved, and their manufacturing process further simplified, if the quantum dots could be electrically excited, as was first demonstrated in the quantum dot LED (QD-LED) structures more than 20 years ago.

Visible light triggers three-step cascade to make 3D drug-like molecules

A team led by chemist Frank Glorius, a professor at the Institute of Organic Chemistry at the University of Münster, has developed a new light-driven reaction sequence. In this triple catalysis, one reaction step triggers the next like three dominoes in a row, toppling one after the other. The molecular transformations occur sequentially in a single reaction vessel. Such one-pot synthesis is considered an ideal process because it is particularly resource- and energy-efficient.

New test certifies quantum measurements that simpler methods cannot mimic

Proving that one quantum measurement is more powerful than another has long been difficult. Physicists from Heinrich Heine University Düsseldorf, Lund University and the University of Innsbruck have now developed and demonstrated a simple technique to certify that a certain class of measurements has properties that cannot be mimicked by simpler means. Their paper is published in the journal PRX Quantum.

Measurements are central to all quantum technologies. They are said to “collapse” the quantum state they act on, destroying its quantum properties and serving as the bridge to the classical world. Curiously, quantum mechanics allows for measurements that are more general than the ones we can directly associate with classical properties of a system.

These generalized measurements, or POVMs, short for Positive Operator Valued Measures, are not just a mathematical curiosity. They are known to improve performance in tasks like distinguishing between quantum states that would otherwise be indistinguishable, extracting more information from quantum sensors and securing quantum communication.

Does multitasking ability really differ by sex? Not in the way you’d think

Research simulates real-life multitasking performance to assess potential differences between men and women. When coordinating five different tasks, men ignored the conversational task more than twice as often as women, while showing similar performance to women in all other tasks.

Multitasking, defined as the ability to perform multiple tasks simultaneously or switch between them, has become a central feature of modern life, occurring in contexts such as driving, work, household activities and even leisure. Despite the widespread stereotype that women are better at multitasking, research has shown only small and inconsistent sex differences, calling into question the existence of meaningful differences in this domain.

In light of this, with the support of the Bial Foundation, André and Diana Szameitat (from Brunel University of London and City St George’s, University of London, UK, respectively) conducted a study to clarify whether sex differences in multitasking exist and to explore possible explanations for the origin of this stereotype.

NASA space telescope maps magnetic fields of ‘Lighthouse’ pulsar

For the first time, scientists have used NASA’s IXPE (Imaging X-ray Polarimetry Explorer) to directly measure the magnetic fields of PSR J1101−6101, a pulsar located within what is often referred to as the Lighthouse Nebula. The results provide new insight into the structure of some of the most extreme objects in the cosmos, as NASA continues to explore the secrets of how the universe works. A paper describing the results was published Thursday in The Astrophysical Journal.

A pulsar is a type of neutron star with a strong magnetic field that spins incredibly fast. The pulsar at the center of the Lighthouse Nebula is rotating 16 times per second. Neutron stars are the leftover cores of massive stars, formed at the end of their life cycles, that possess more mass than the sun. They are condensed down to the size of a city, making them natural laboratories for studying extreme physics.

In June 2025, IXPE spent nearly 18 days focused on the Lighthouse Nebula.

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