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The many pathways driving liver inflammation in MASH

Online now: Intra-and extrahepatic inflammation in MASH is driven by various hits such as lipotoxicity, the gut microbiome, and proinflammatory diets. Inflammation contributes to hepatic and systemic complications, including cardiovascular diseases. Beneficial drugs in MASH might target metabolic and inflammatory pathways.

Inflammation is a key driver of this disease, and effective future therapies might have to target metabolic and inflammatory pathways.

Assessment of inflammation, i.e., MASH in humans, is still challenging as it might appear intermittently during the clinical course and could be missed by liver biopsy. Future non-invasive strategies assessing the liver’s inflammatory burden are eagerly awaited.

Recent Scientific findings that support the Phantom Primal Eye as a comprehensive Biological Solution to the Mind-Body Problem

The Primal Eye (the pineal/ parietal eyes predates the paired lateral eyes, so “third eye” is technically a misnomer) theory breaks this deadlock by moving the goalposts from philosophy to evolutionary physiology. It suggests that consciousness is

Physicists just turned glass into a powerful quantum security device

Scientists have turned simple glass into a powerful quantum communication device that could safeguard data against future quantum attacks. The chip combines stability, speed, and versatility—handling both ultra-secure encryption and record-breaking random number generation in one compact system.

A safer, more effective atrial fibrillation treatment method using magnetic gel may be on the way

Atrial fibrillation is a common heart condition characterized by a rapid, irregular heartbeat stemming from the heart’s upper chamber. It is a leading cause of stroke from clots that form in a small pouch of the heart called the left atrial appendage (LAA). While several treatment options exist, they have many drawbacks, and risks often remain. But now, researchers have developed a promising new treatment involving magnetic fluids. Their study, published in Nature, describes the new procedure and results from rat and pig studies.

Atrial fibrillation treatment options Blood thinners are a common treatment for atrial fibrillation. However, some patients cannot take them due to an increased risk of bleeding. Another option is closing off the LAA with a device. This is referred to as left atrial appendage occlusion (LAAO). While the devices that are currently available reduce stroke risk, they can leave small leaks and attract clots on or around the device itself. One of these devices is the Watchman occluder—a metallic transcatheter LAAO device.

One reason blocking off the LAA is difficult is that its shape varies from patient to patient, and is often rather odd. Names of these strange and difficult-to-fill shapes include cauliflower, cactus, chicken wing and the most challenging type—the windsock. Some improvements have been made to attempt to fit these shapes better, but issues remain.

Self-repairing spacecraft could change future missions

Healable spacecraft structures could soon be possible thanks to cutting-edge composite technology. Swiss companies CompPair and CSEM with Belgian company Com&Sens have partnered with the European Space Agency (ESA) to modify their self-healing carbon fiber product for use in space transportation.

Project Cassandra (a loose abbreviation of Composite Autonomous SenSing AnD RepAir) includes sensors and a heating element into a composite carbon-fiber material, allowing spacecraft to autonomously repair initial stages of damage.

Cassandra is part of ESA’s Future Innovation Research in Space Transportation (FIRST!) Initiative which is finding and testing innovative technology that will benefit European space transportation.

Is Spacetime Fundamental, or is it Emergent? With Brian Cox

In this conversation, Neil deGrasse Tyson and co-host Chuck Nice are joined by physicist Brian Cox to explore one of the deepest open questions in modern physics: whether space and time are fundamental—or emergent.

The discussion spans emergent spacetime, quantum entanglement, black holes, wormholes, and the black hole information paradox, including ideas like ER = EPR, causality protection, and whether information is ever truly destroyed. The core idea centers on the possibility that spacetime itself emerges from deeper quantum information structures, challenging our intuitive understanding of reality.

From ‘Are We The Universe’s Way of Knowing Itself? With Brian Cox’: • Are We The Universe’s Way of Knowing Itsel…

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Why Time Flows Differently Between Galaxies

Thanks to Radiacode for sponsoring this video. Use the promo code “PBS” to get an exclusive 10% discount at: https://103.radiacode.com/PBS The universe is expanding and that expansion is accelerating under the power of dark energy and eventually all matter and energy will be dispersed over such unthinkable distances that nothing can stop space from blowing up infinitely. Unless of course cosmologists blundered and dark energy doesn’t even exist. Then it’s back to the drawing board. Sign Up on Patreon to get access to the Space Time Discord! / pbsspacetime Check out the Space Time Merch Store https://www.pbsspacetime.com/shop PBS Member Stations rely on viewers like you. To support your local station, go to: http://to.pbs.org/DonateSPACE Sign up for the mailing list to get episode notifications and hear special announcements! https://mailchi.mp/1a6eb8f2717d/space… the Entire Space Time Library Here: https://search.pbsspacetime.com/ Hosted by Matt O’Dowd Written by Matt O’Dowd Post Production by Leonardo Scholzer, Yago Ballarini & Stephanie Faria Directed by Andrew Kornhaber Associate Producer: Bahar Gholipour Executive Producer: Andrew Kornhaber Executive in Charge for PBS: Maribel Lopez Director of Programming for PBS: Gabrielle Ewing Assistant Director of Programming for PBS: John Campbell Spacetime is a production of Kornhaber Brown for PBS Digital Studios. This program is produced by Kornhaber Brown, which is solely responsible for its content. © 2024 PBS. All rights reserved. End Credits Music by J.R.S. Schattenberg: / multidroideka Space Time Was Made Possible In Part By: Big Bang Wojciech Szymski Bryce Fort Peter Barrett Alexander Tamas Morgan Hough Juan Benet Vinnie Falco Mark Rosenthal Supernova Grace Biaelcki Glenn Sugden Ethan Cohen Stephen Wilcox Mark Heising Hypernova Spencer Jones Dean Galvin Michael Tidwell Robert DeChellis Stephen Spidle Massimiliano Pala Justin Lloyd Matthew Pabst David Giltinan Kenneth See Gregory Forfa Alex Kern Zubin Dowlaty Scott Gorlick Paul Stehr-Green Ben Delo Scott Gray Антон Кочков Robert Ilardi John R. Slavik Donal Botkin Chuck Zegar Daniel Muzquiz Gamma Ray Burst Bryan White Aaron Pinto Kacper Cieśla Satwik Pani Param Saxena John De Witt Nathaniel Bennett Sandhya Devi Michael Oulvey Arko Provo Mukherjee Mike Purvis Christopher Wade Anthony Crossland Grace Seraph Stephen Saslow Tomaz Lovsin Anthony Leon Lori Ferris Koen Wilde Nicolas Katsantonis Richard Steenbergen Joe Pavlovic Kyle Luzny Chuck Lukaszewski Jerry Thomas Nikhil Sharma John Anderson Bradley Ulis Craig Falls Kane Holbrook Ross Story Harsh Khandhadia Michael Lev Rad Antonov Terje Vold James Trimmier Jeremy Soller Paul Wood Kent Durham jim bartosh John H. Austin, Jr. Faraz Khan Almog Cohen Daniel Jennings Jeremy Reed David Johnston Michael Barton Isaac Suttell Bleys Goodson Mark Delagasse Mark Daniel Cohen Shane Calimlim Tybie Fitzhugh Eric Kiebler Craig Stonaha Frederic Simon Jim Hudson Michael Purcell John Funai Adrien Molyneux Bradley Jenkins Vlad Shipulin Justin Waters Thomas Dougherty Zac Sweers Dan Warren Joseph Salomone Julien Dubois.

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