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New memory chip survives temperatures hotter than lava

The electronics inside your phone, your car, and every satellite currently orbiting Earth share one critical weakness: heat. Push them past about 200 degrees Celsius and they start to fail. For decades, that thermal ceiling has been one of the hardest walls in engineering. Now a team at the University of Southern California may have just found a way around it.

In a study published in Science, researchers led by Joshua Yang, Arthur B. Freeman Chair Professor at the Ming Hsieh Department of Electrical and Computer Engineering of the USC Viterbi School of Engineering and the USC School of Advanced Computing, report a new type of electronic memory device that kept working reliably at 700 degrees Celsius, hotter than molten lava and far beyond anything previously achieved in its class. The device showed no signs of reaching its limit. Seven hundred degrees was simply as hot as their testing equipment could go.

“You may call it a revolution,” Yang said. “It is the best high-temperature memory ever demonstrated.”

Benefits and Harms of Dementia Screening for Family Members of Older Adults: A Randomized Clinical Trial

Alzheimer disease and related dementias screening of adults ≥65 years in primary care had no significant benefits or harms on family member quality of life or psychological well-being.

Question How does screening adults aged 65 years and older for dementia in primary care affect their family members’ health-related quality of life, stress, and perceived readiness to provide care?

Findings In this randomized clinical trial that included 1808 patient-family member dyads, there was no significant difference in benefit of screening to family members, measured by physical and mental component summary scores, and no difference in harm, measured by depression and anxiety between the screen and no screen groups over time.

Meaning These findings suggest that screening older adults for dementia in primary care did not improve or worsen their family members’ quality of life or psychological well-being.

The Science of piRNA and Predicting Death With a Blood Test

Researchers have identified specific small non-coding RNA molecules, known as piRNAs, that may serve as potent biomarkers for predicting all-cause mortality. This breakthrough suggests that a single blood test could eventually quantify biological aging and help clinicians identify high-risk patients long before clinical symptoms of age-related decline emerge. More on the research.

A new study analyzed piRNA — first discovered in 2006 — as a strong predictor of short-term survival in older patients. It could one day be a simple blood test.

When pomegranates meet the artery wall: How gut-derived metabolites may stabilize atherosclerotic plaques

For years, pomegranates have enjoyed a reputation as a “heart-healthy” fruit. As a cardiovascular researcher, I have often been asked a seemingly simple question: If pomegranates are so good for us, how exactly do they work? Our recent study, published in Antioxidants, set out to answer that question—not by focusing on the fruit itself, but by following what happens after the body and, crucially, the gut microbiome gets involved.

Atherosclerosis—an inflammatory disease that underlies heart attacks and strokes—develops slowly. It begins when low-density lipoprotein (LDL) particles become trapped and oxidized in artery walls, triggering immune cell recruitment, chronic inflammation, and eventually plaque formation. Drugs such as statins are effective but not perfect; many patients continue to carry significant “residual risk.” This has driven interest in other preventative and therapeutic agents. These include nutraceuticals—bioactive food components that may potentially complement existing therapies.

Among these, pomegranate polyphenols, especially a compound called punicalagin, have stood out. But there is a catch. Punicalagin itself is poorly absorbed. What actually enters the bloodstream in meaningful amounts are urolithins: small molecules made when the gut bacteria metabolize punicalagin and its breakdown product, ellagic acid.

Big Data Approach to Assessment of an Aldosterone-Renin Ratio for Detection of Potential Surgical Cases of Primary Aldosteronism

RESEARCH ARTICLE:

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MHealth Intervention to Improve Hypertension Care in High-Risk Patients

RESEARCH ARTICLE: mHealth Intervention to Improve Hypertension Care in High-Risk Patients @valnp @countryside1991 @PDrawz

BACKGROUND: The mGlide RCT (randomized controlled trial) evaluated whether a pharmacist-led, mobile health technology facilitated care model improves hypertension control in diverse populations. METHODS: We recruited adult English, Spanish, or Hmong-speaking patients with uncontrolled hypertension from a large health care system and smaller community clinics serving low-income patients. Participants were randomized 1:1 to mGlide or usual care. The 6-month intervention included daily blood pressure (BP) self-monitoring using a smartphone and wireless monitor, automated app-based data sharing, and responsive medication adjustment by a pharmacist-led provider-team. Comparison participants received a digital monitor. Outcomes included mean 6-month systolic BP (SBP), 12-month sustained BP control, 24-hour ambulatory BP and patient activation.

The Man Growing Organs On Demand

The initial heart transplant was not greeted with universal applause. Shortly after Dr. Christiaan Barnard performed the procedure for the first time in 1967, people bombarded his hospital in South Africa with letters that characterized the doctor as a butcher and a ghoul. A fellow cardiologist likened the operation to a form of cannibalism. Many people criticized Barnard for picking one life over another and playing God.

Justin Rebo, KindBio and their fantastic sacks.

Arctic Stabilization Initiative

Renaissance Philanthropy is facilitating infrastructure development for tackling an extremely important problem which affects all of humanity — preventing us from crossing a deadly climate tipping point that would result in a self-reinforcing cycle of greenhouse gas release and ice melting. Kudos to them for looking this problem right in the eye!

Fund | US | Climate, Energy, Geologic Hydrogen | The Chimaera Fund aims to responsibly and rapidly scale geologic hydrogen – the first new primary energy source discovered in 80 years.

This artificial leaf turns pollution into power

Cambridge researchers have engineered a solar-powered “artificial leaf” that mimics photosynthesis to make valuable chemicals sustainably. Their biohybrid device combines organic semiconductors and enzymes to convert CO₂ and sunlight into formate with high efficiency. It’s durable, non-toxic, and runs without fossil fuels—paving the way for a greener chemical industry.

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