Omer et al. design a DNA origami box with a lid held closed by an elastic single-stranded DNA spring. The box may selectively open in blood vessels with pathological levels of shear flow, facilitating drug delivery to sites of thrombosis while minimizing off-target toxicity. It should be noted that this paper focused entirely on the box’s design and mechanical validation (via optical tweezers) and did not perform any experiments to show drug delivery. Nonetheless, this is a good start and I’m glad to see people thinking about DNA origami for therapeutic applications. [ https://pubs.acs.org/doi/10.1021/acs.nanolett.5c04066](https://pubs.acs.org/doi/10.1021/acs.nanolett.5c04066)

Click to copy section linkSection link copied!