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AAVmediated FGF21 gene therapy promotes health span extension by wholebody tissuespecific adaptations

Bosch and colleagues described that one-time AAV-FGF21 gene therapy in aged mice induced whole-body tissue-specific adaptations, including improved metabolic and mitochondrial function, restored proteostasis, and reduced adiposity, inflammation, fibrosis, and amyloidosis, thereby maintaining systemic cell fitness, preventing multi-organ age-related pathology, and prolonging health span.

Human brain stimulation engages different gene programs in different cell types

Nature’s brief summary of a paper (by Moore et al.) which transcriptomically maps how electrical stimulation of ex vivo human brain tissue triggers a range of previously unknown gene expression programs.


Genetic signatures of stimulation coincide with the strengthening of cell assemblies in samples of human brain tissue.

Can AI Help Detect Disease Before Your Pet Gets Sick? | Dr. Ragen McGowan — Nestlé Purina

Can AI tell how your pet feels? Dr. Ragen McGowan, Ph.D. — Director of Global Digital & AI Product Development, Nestlé Purina North America.


What if your dog or cat could tell you how they’re feeling?

Today, artificial intelligence may be giving us a new way to listen.

By continuously monitoring things like activity, eating, sleep, elimination and other behaviors, AI can begin to establish what’s normal for an individual animal — and potentially detect subtle changes that humans would never notice.

Dr. Ragen McGowan, Ph.D. is Director of Global Digital & AI Product Development at Nestlé Purina (https://www.purina.com/pet-experts/rm

The Agentic AI and Quantum Convergence: Innovation and Cybersecurity Imperatives for US Government Agencies and Contractors$

GovCon Expert Chuck Brooks outlines the governance, cryptographic inventory and resilience steps agencies and contractors need now.

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